Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery

Ionizable lipid nanoparticles for in utero mRNA delivery

(2021) Rachel S. Riley et al.   Science Advances

The Future of In Utero Gene Therapy

(2020) William H. Peranteau et al.   Molecular Diagnosis & Therapy

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment?

(2020) Eleonora Truzzi et al.   Nanomaterials

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

(2020) Valentina Francia et al.   BIOCONJUGATE CHEMISTRY

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polymer Topology Determines the Formation of Protein Corona on Core–Shell Nanoparticles

(2020) Martina Schroffenegger et al.   ACS Nano

Exploiting the placenta for nanoparticle-mediated drug delivery during pregnancy

(2020) Christian G. Figueroa-Espada et al.   ADVANCED DRUG DELIVERY REVIEWS

Delivery technologies for in utero gene therapy

(2020) Rohan Palanki et al.   ADVANCED DRUG DELIVERY REVIEWS

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

(2019) Khalid A. Hajj et al.   Small

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

Prenatal exome sequencing analysis in fetal structural anomalies detected by ultrasonography (PAGE): a cohort study

(2019) Jenny Lord et al.   LANCET

In utero gene editing for monogenic lung disease

(2019) Deepthi Alapati et al.   Science Translational Medicine

A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA

(2019) Markus Baiersdörfer et al.   Molecular Therapy-Nucleic Acids

Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening

(2019) Pedro P.G. Guimaraes et al.   JOURNAL OF CONTROLLED RELEASE

G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a

(2018) Daniel S. Roseman et al.   MOLECULAR THERAPY

Fetal gene therapy for neurodegenerative disease of infants

(2018) Giulia Massaro et al.   NATURE MEDICINE

In utero nanoparticle delivery for site-specific genome editing

(2018) Adele S. Ricciardi et al.   Nature Communications

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

Alnylam launches era of RNAi drugs

(2018) Ken Garber   NATURE BIOTECHNOLOGY

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

(2018) Qiang Cheng et al.   ADVANCED MATERIALS

Delivery of mRNA Therapeutics for the Treatment of Hepatic Diseases

(2018) Zeljka Trepotec et al.   MOLECULAR THERAPY

Prenatal gene therapy offers the earliest possible cure

(2018) Sarah DeWeerdt   NATURE

In utero CRISPR-mediated therapeutic editing of metabolic genes

(2018) Avery C. Rossidis et al.   NATURE MEDICINE

Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery

(2017) Diana P. Gaspar et al.   MOLECULAR PHARMACEUTICS

Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA

(2017) Siddharth Patel et al.   NANO LETTERS

Plasma protein adsorption and biological identity of systemically administered nanoparticles

(2017) Dongyu Chen et al.   Nanomedicine

In vivo protein corona patterns of lipid nanoparticles

(2017) A. Amici et al.   RSC Advances

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Intentional formation of a protein corona on nanoparticles: Serum concentration affects protein corona mass, surface charge, and nanoparticle–cell interaction

(2016) Christine Gräfe et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Personalized liposome–protein corona in the blood of breast, gastric and pancreatic cancer patients

(2016) Valentina Colapicchioni et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Materials for non-viral intracellular delivery of messenger RNA therapeutics

(2016) Kevin J. Kauffman et al.   JOURNAL OF CONTROLLED RELEASE

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

In utero stem cell transplantation and gene therapy: rationale, history, and recent advances toward clinical application

(2016) Graça Almeida-Porada et al.   Molecular Therapy-Methods & Clinical Development

The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery

(2016) Francesco Cardarelli et al.   Scientific Reports

An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

(2015) Bin Li et al.   NANO LETTERS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Silver nanoparticles in simulated biological media: a study of aggregation, sedimentation, and dissolution

(2010) Larissa V. Stebounova et al.   JOURNAL OF NANOPARTICLE RESEARCH

Robust In Vivo Transduction of Nervous System and Neural Stem Cells by Early Gestational Intra Amniotic Gene Transfer Using Lentiviral Vector

(2010) David H Stitelman et al.   MOLECULAR THERAPY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential Function of Amniotic Fluid in Fetal Development—Novel Insights by Comparing the Composition of Human Amniotic Fluid with Umbilical Cord and Maternal Serum at Mid and Late Gestation

(2009) Xing-Long Tong et al.   Journal of the Chinese Medical Association

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

(2008) Steven J. Howe et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter

(2007) Masayuki Endo et al.   MOLECULAR THERAPY