Editorial Material
Biochemistry & Molecular Biology
Paul S. Katz, Deirdre C. Lyons
Summary: Two new papers explore the molecular and developmental mechanisms of cephalopod visual development, revealing that their eyes, despite resembling ours, have different neural circuitry with forward-facing photoreceptors connected to the brain rather than the retina.
Article
Multidisciplinary Sciences
Dingxi Zhou, Mariana Borsa, Daniel J. Puleston, Susanne Zellner, Jesusa Capera, Sharon Sanderson, Martina Schifferer, Svenja S. Hester, Xin Ge, Roman Fischer, Luke Jostins, Christian Behrends, Ghada Alsaleh, Anna Katharina Simon
Summary: This study identifies interleukin-7 receptor-alpha as a key cargo in proliferating CD4+ T cells within the autophagosomal compartment using a transgenic mouse model. Moreover, the authors uncover the mechanism by which excessive surface interleukin-7 receptor-alpha affects T cell proliferation.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Moujtaba Y. Kasmani, Weiguo Cui
Summary: The bromodomain-containing protein BRD4 is shown to play a critical role in the effector function of CD8 T cells responding to infection and cancer in a recent study published in JEM.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Review
Construction & Building Technology
Mohammad Kaiser Ahamed, Hongxu Wang, Paul J. Hazell
Summary: This paper provides an overview of nature-inspired materials applicable to buildings and civil structures, discussing current research on bio-inspired novel cementitious composites, bacteria-enhanced materials, building envelopes and facade systems, advanced manufacturing processes, and their applications. It also provides insights for future research on designing and developing bio-inspired building materials and resilient structures.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Review
Oncology
Ashwathi Puravankara Menon, Beatriz Moreno, Daniel Meraviglia-Crivelli, Francesca Nonatelli, Helena Villanueva, Martin Barainka, Angelina Zheleva, Hisse M. van Santen, Fernando Pastor
Summary: CD3 complex is the first signal sensed by TCR of lymphocytes for activation, making it an attractive receptor to determine immune response fate. This article discusses the assembly of CD3-TCR complex and the approaches to harness CD3 activity for immunotherapy.
Article
Cardiac & Cardiovascular Systems
Fen Gao, Rui Bai, Weiwei Qin, Bin Liang, Zhiming Yang, Huiyu Yang
Summary: Periostin plays a key role in enhancing macrophage foam cell formation induced by Ang II, by suppressing cholesterol efflux, and its expression is regulated by oxLDL and Twist2-mediated transactivation. In patients with atherosclerosis, there is a significant positive correlation between serum periostin and Ang II levels.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Immunology
Xiaoxue Deng, Lingxia Wang, Yunze Zhai, Qiuyue Liu, Fengxue Du, Yu Zhang, Wenxing Zhao, Tingtao Wu, Yiwen Tao, Jie Deng, Yongbing Cao, Pei Hao, Jiazi Ren, Yunli Shen, Zuoren Yu, Yuejuan Zheng, Haibing Zhang, Haikun Wang
Summary: Regulatory T (T-reg) cells are important for maintaining immune balance, and RIPK1 plays a critical role in regulating T-reg cell survival and homeostasis by controlling both apoptosis and necroptosis mechanisms.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Immunology
Yu-Jyun Li, Chi-Yuan Chen, Jeng-How Yang, Ya-Fang Chiu
Summary: New research suggests that statins may play a role in countering influenza A virus infections and modulating the host immune response, and further investigation is warranted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Yijun Lin, Meijuan Bai, Shuo Wang, Lingling Chen, Zixuan Li, Chenchen Li, Peijuan Cao, Yan Chen
Summary: This study identifies lactate as a key trigger for obesity-induced inflammation and systemic insulin resistance. Accumulation of lactate in adipocytes leads to apoptosis and release of cytokines, which initiates inflammation and insulin resistance.
Article
Oncology
Michael W. Knitz, Thomas E. Bickett, Laurel B. Darragh, Ayman J. Oweida, Shilpa Bhatia, Benjamin Van Court, Shiv Bhuvane, Miles Piper, Jacob Gadwa, Adam C. Mueller, Diemmy Nguyen, Varuna Nangia, Douglas G. Osborne, Xiyuan Bai, Sarah E. Ferrara, Mary-Keara Boss, Andrew Goodspeed, Matthew A. Burchill, Beth A. Jiron Tamburini, Edward D. Chan, Curtis R. Pickering, Eric T. Clambey, Sana D. Karam
Summary: The study reveals that regulating Treg functionality and DC activation status is crucial for generating a T cell effector response in highly radioresistant HNSCC tumors. The findings suggest a new therapeutic approach for reprogramming the tumor microenvironment in HNSCCs resistant to conventional radioimmunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, Research & Experimental
Danni Yu, Quanhui Dai, Zixiang Wang, Steven X. Hou, Ling V. Sun
Summary: This study aimed to explore the role of ARF1 in intestinal epithelial cells (IECs) and reveal the possible mechanism. The results showed that ARF1 is essential for ISC proliferation and differentiation. Loss of ARF1 increased susceptibility to DSS-induced colitis and gut microbial dysbiosis. Additionally, RNA-seq analysis revealed alterations in multiple metabolic pathways.
Review
Immunology
Beatriz Leon, Andre Ballesteros-Tato
Summary: Asthma affects over 339 million people worldwide, with the breakdown of immune tolerance to inhaled allergens and aberrant Th2 cell responses playing key roles in its development. Targeting the Th2 cell pathway has become an attractive option for moderate to severe asthmatic patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geosciences, Multidisciplinary
Beier Zhou, Hui Zhang, Richard Evans
Summary: This study proposes a sustainable recovery framework that evaluates the recovery level of families and communities from three dimensions: Element, Structure, and Function. Through surveys and interviews in four towns in Wenchuan County, Mainland China, the internal mechanisms that influence sustainable recovery were identified. Practical recommendations are provided to improve disaster recovery management. This framework can assist in the development of recovery standards and evaluations at different levels in China and other parts of the world.
INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION
(2022)
Article
Endocrinology & Metabolism
Algerta Marku, Lorenzo Da Dalt, Alessandra Galli, Nevia Dule, Paola Corsetto, Angela Maria Rizzo, Annalisa Moregola, Patrizia Uboldi, Fabrizia Bonacina, Paola Marciani, Michela Castagna, Alberico Luigi Catapano, Giuseppe Danilo Norata, Carla Perego
Summary: This study reveals that pancreatic PCSK9 is a critical regulator of beta-cell function, affecting insulin secretion and cellular function through modulation of cholesterol homeostasis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Immunology
Carlos Plaza-Sirvent, Bei Zhao, Alisha W. Bronietzki, Marina C. Pils, Neda Tafrishi, Marc Schuster, Till Strowig, Ingo Schmitz
Summary: Autophagy plays a crucial role in regulating T cells, especially in maintaining gut homeostasis.
FRONTIERS IN IMMUNOLOGY
(2021)
