Oxysterols are allosteric activators of the oncoprotein Smoothened

Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo

(2011) Jared S. Johnson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Oxysterols direct B-cell migration through EBI2

(2011) Changlu Liu et al.   NATURE

Oxysterols direct immune cell migration via EBI2

(2011) Sébastien Hannedouche et al.   NATURE

Cyclopamine and Hedgehog Signaling: Chemistry, Biology, Medical Perspectives

(2010) Philipp Heretsch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

(2010) James Kim et al.   CANCER CELL

Lipid Binding Requirements for Oxysterol-binding Protein Kes1 Inhibition of Autophagy and Endosome-trans-Golgi Trafficking Pathways

(2010) Marissa A. LeBlanc et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons

(2010) Kiwon Park et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

(2010) Monique T. Barakat et al.   TRENDS IN MOLECULAR MEDICINE

Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor

(2009) C. M. Rominger et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Interactions of oxysterols with membranes and proteins

(2009) Vesa M. Olkkonen et al.   MOLECULAR ASPECTS OF MEDICINE

Oxysterol signaling links cholesterol metabolism and inflammation via the liver X receptor in macrophages

(2009) Dániel Töröcsik et al.   MOLECULAR ASPECTS OF MEDICINE

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Side Chain Oxygenated Cholesterol Regulates Cellular Cholesterol Homeostasis through Direct Sterol-Membrane Interactions

(2008) Sarah E. Gale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Implications of Plasma Membrane Condensation for T Cell Activation

(2008) Carles Rentero et al.   PLoS One

ent-Steroids: Novel tools for studies of signaling pathways

(2008) Douglas F. Covey   STEROIDS