WNT signaling and cancer stemness

PD-L1 interacts with Frizzled 6 to activate β-catenin and form a positive feedback loop to promote cancer stem cell expansion

(2022) Lingchen Fu et al.   ONCOGENE

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT

(2022) Marion Flum et al.   ONCOGENE

Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1

(2022) Yingying Han et al.   Cell Reports

Wnt5A and TGFβ1 Converges through YAP1 Activity and Integrin Alpha v Up-Regulation Promoting Epithelial to Mesenchymal Transition in Ovarian Cancer Cells and Mesothelial Cell Activation

(2022) Zeinab Dehghani-Ghobadi et al.   Cells

Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

(2022) Yun Zhang et al.   NATURE CELL BIOLOGY

ROR1 targeting with the antibody drug-conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models

(2021) Tiziana Vaisitti et al.   BLOOD

E7386, a selective inhibitor of the interaction between β-catenin and CBP, exerts antitumor activity in tumor models with activated canonical Wnt signaling

(2021) Kazuhiko Yamada et al.   CANCER RESEARCH

LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways

(2021) Jaewoong Jang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Wnt–β-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression

(2021) Jasmin Quandt et al.   NATURE IMMUNOLOGY

Anti-angiogenic agents — overcoming tumour endothelial cell anergy and improving immunotherapy outcomes

(2021) Zowi R. Huinen et al.   Nature Reviews Clinical Oncology

Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing

(2021) Abhijeet P. Deshmukh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy

(2021) Nicholas C. DeVito et al.   Cell Reports

Parsing β-catenin’s cell adhesion and Wnt signaling functions in malignant mammary tumor progression

(2021) David Buechel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WNT as a Driver and Dependency in Cancer

(2021) Marie J. Parsons et al.   Cancer Discovery

Transcriptomic Determinants of Response to Pembrolizumab Monotherapy across Solid Tumor Types

(2021) Razvan Cristescu et al.   CLINICAL CANCER RESEARCH

A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers

(2021) A. Fatehullah et al.   NATURE CELL BIOLOGY

Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways

(2021) Lukas Kraehenbuehl et al.   Nature Reviews Clinical Oncology

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

(2021) Tomasz Radaszkiewicz et al.   eLife

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice

(2020) Simone Ragusa et al.   JOURNAL OF CLINICAL INVESTIGATION

The emerging role of Wnt5a in the promotion of a pro-inflammatory and immunosuppressive tumor microenvironment

(2020) Pablo Lopez-Bergami et al.   CANCER AND METASTASIS REVIEWS

Blockade of β-Catenin–Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration

(2020) Lu Ji et al.   CANCER RESEARCH

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immune-related adverse events of checkpoint inhibitors

(2020) Manuel Ramos-Casals et al.   Nature Reviews Disease Primers

Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

(2020) Priscilla Cheung et al.   Cell Stem Cell

Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP ‐1 in breast cancer

(2020) Nora Feldker et al.   EMBO JOURNAL

Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma

(2020) Weiwei Tao et al.   Nature Communications

A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer

(2020) Hongwei Liao et al.   Cell Discovery

Cell dormancy plasticity: quiescence deepens into senescence through a dimmer switch

(2020) Kotaro Fujimaki et al.   PHYSIOLOGICAL GENOMICS

Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

(2020) Shivani Srivastava et al.   CANCER CELL

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

(2020) Ievgenia Pastushenko et al.   NATURE

WNT/β-catenin pathway activation correlates with immune exclusion across human cancers

(2019) Jason J. Luke et al.   CLINICAL CANCER RESEARCH

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody

(2019) Suping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

(2019) Cornelia Kröger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic testing, tumor microenvironment and targeted therapy of Hedgehog-related human cancers

(2019) Masaru Katoh   CLINICAL SCIENCE

Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1

(2019) Syed S. Islam et al.   EBioMedicine

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

(2019) Tianzuo Zhan et al.   Nature Communications

β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma

(2019) Marina Ruiz de Galarreta et al.   Cancer Discovery

Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments

(2019) Shreya Raghavan et al.   Journal for ImmunoTherapy of Cancer

CDK 12 drives breast tumor initiation and trastuzumab resistance via WNT and IRS 1‐ErbB‐ PI 3K signaling

(2019) Hee‐Joo Choi et al.   EMBO REPORTS

CSCs in Breast Cancer—One Size Does Not Fit All: Therapeutic Advances in Targeting Heterogeneous Epithelial and Mesenchymal CSCs

(2019) Andrew Sulaiman et al.   Cancers

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer

(2019) Daniela Unterleuthner et al.   ANGIOGENESIS

STAT3-Induced Wnt5a Provides Chronic Lymphocytic Leukemia Cells with Survival Advantage

(2019) Uri Rozovski et al.   JOURNAL OF IMMUNOLOGY

Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review)

(2018) Masaru Katoh   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype

(2018) Sang Cheul Oh et al.   Nature Communications

Transcription factor PROX1 suppresses Notch pathway activation via the nucleosome remodeling and deacetylase complex in colorectal cancer stem-like cells

(2018) Jenny Högström et al.   CANCER RESEARCH

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

(2018) Joy Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer

(2018) Michitaka Nakano et al.   ONCOGENE

WNT Signaling in Cancer Immunosurveillance

(2018) Lorenzo Galluzzi et al.   TRENDS IN CELL BIOLOGY

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

(2018) Lei Zhang et al.   NATURE

Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)

(2017) Masaru Katoh   INTERNATIONAL JOURNAL OF ONCOLOGY

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

(2017) Sydney M. Shaffer et al.   NATURE

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

(2017) Tuomas Tammela et al.   NATURE

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

(2016) Vassiliki A. Boussiotis   NEW ENGLAND JOURNAL OF MEDICINE

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

(2016) Sergio P. Acebron et al.   TRENDS IN CELL BIOLOGY

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling

(2015) Man-Tzu Wang et al.   CELL

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Yes-associated protein controls the cell density regulation of Hedgehog signaling

(2014) M Tariki et al.   Oncogenesis

Cancer stem cells: The challenges ahead

(2013) Jan Paul Medema   NATURE CELL BIOLOGY

CD133 expression is not restricted to stem cells, and both CD133+ and CD133– metastatic colon cancer cells initiate tumors

(2008) Sergey V. Shmelkov et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY