LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways

Paeonia lactiflora root extract suppresses cancer cachexia by down-regulating muscular NF-κB signalling and muscle-specific E3 ubiquitin ligases in cancer-bearing mice

(2019) Taehyun Bae et al.   JOURNAL OF ETHNOPHARMACOLOGY

Role of Wnt signaling during inflammation and sepsis: A review of the literature

(2018) Khosrow Siamak Houschyar et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

WNT ligands control initiation and progression of human papillomavirus-driven squamous cell carcinoma

(2018) Dario Zimmerli et al.   ONCOGENE

Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitro

(2018) Abigail Kora Suwala et al.   Oncotarget

Neutrophils mitigate the systemic host response during endotoxemia in mice

(2018) Anne Jan van der Meer et al.   IMMUNOLOGY

Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes

(2018) Pedro P.G. Guimaraes et al.   JOURNAL OF CONTROLLED RELEASE

Prevalence and clinical significance of early high Endotoxin Activity in septic shock: An observational study

(2017) Maurizio Bottiroli et al.   JOURNAL OF CRITICAL CARE

Wnt/beta-catenin pathway: modulating anticancer immune response

(2017) Sachin Gopalkrishna Pai et al.   Journal of Hematology & Oncology

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

Mitigation of sepsis-induced inflammatory responses and organ injury through targeting Wnt/β-catenin signaling

(2017) Archna Sharma et al.   Scientific Reports

LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974

(2017) Jaewoong Jang et al.   Scientific Reports

Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase

(2016) Akbar Ahmad et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Differential Paradigms in Animal Models of Sepsis

(2016) S. Manoj Kumar Kingsley et al.   Current Infectious Disease Reports

Therapeutic effects of antibiotic drug tigecycline against cervical squamous cell carcinoma by inhibiting Wnt/β-catenin signaling

(2015) Hui Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The wingless-related integration site-5a/secreted frizzled-related protein-5 system is dysregulated in human sepsis

(2015) D. M. Schulte et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells

(2015) Ulf D. Kahlert et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974

(2015) Jonathan D Boone et al.   LABORATORY INVESTIGATION

β-catenin regulates NF-κB activity and inflammatory cytokine expression in bronchial epithelial cells treated with lipopolysaccharide

(2014) JAEWOONG JANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Role of the Liver in Sepsis

(2014) Jun Yan et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology of severe sepsis

(2013) Florian B Mayr et al.   Virulence

A Wnt/β-catenin negative feedback loop inhibits interleukin-1-induced matrix metalloproteinase expression in human articular chondrocytes

(2012) Bin Ma et al.   ARTHRITIS AND RHEUMATISM

Differential Regulation of the Mouse and Human Wnt5a Alternative Promoters A and B

(2012) Karen S. Katula et al.   DNA AND CELL BIOLOGY

Requirement of the NF-κB pathway for induction of Wnt-5A by interleukin-1β in condylar chondrocytes of the temporomandibular joint: functional crosstalk between the Wnt-5A and NF-κB signaling pathways

(2010) Xian-Peng Ge et al.   OSTEOARTHRITIS AND CARTILAGE

Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction

(2009) Yuhang Zhang et al.   DEVELOPMENTAL CELL