PD-L1 interacts with Frizzled 6 to activate β-catenin and form a positive feedback loop to promote cancer stem cell expansion

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axis

(2020) Fatmah A. Mansour et al.   OncoImmunology

Amplifications of stemness genes and the capacity of breast tumors for metastasis

(2020) Nikolai Litviakov et al.   Oncotarget

β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion

(2020) Linyong Du et al.   JOURNAL OF EXPERIMENTAL MEDICINE

WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer

(2019) Lorenzo Castagnoli et al.   ONCOGENE

PD-L1 promotes colorectal cancer stem cell expansion by activating HMGA1-dependent signaling pathways

(2019) Fang Wei et al.   CANCER LETTERS

MACC1 regulates PDL1 expression and tumor immunity through the c‐Met/AKT/mTOR pathway in gastric cancer cells

(2019) Gangling Tong et al.   Cancer Medicine

Tumor-Intrinsic PD-L1 Signaling in Cancer Initiation, Development and Treatment: Beyond Immune Evasion

(2018) Peixin Dong et al.   Frontiers in Oncology

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

(2017) Matthew A. Coelho et al.   IMMUNITY

Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage

(2017) G Corda et al.   Oncogenesis

CD44+ Cells in Head and Neck Squamous Cell Carcinoma Suppress T-Cell-Mediated Immunity by Selective Constitutive and Inducible Expression of PD-L1

(2016) Y. Lee et al.   CLINICAL CANCER RESEARCH

Functional and prognostic significance of the genomic amplification of frizzled 6 (FZD6 ) in breast cancer

(2016) Gabriele Corda et al.   JOURNAL OF PATHOLOGY

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Prognostic value of PDL1 expression in pancreatic cancer

(2016) David J. Birnbaum et al.   Oncotarget

SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma

(2016) Takayuki Kawai et al.   Scientific Reports

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

LGR5 Promotes Breast Cancer Progression and Maintains Stem-Like Cells Through Activation of Wnt/β-Catenin Signaling

(2015) Lu Yang et al.   STEM CELLS

High PD-L1 Expression Correlates with Metastasis and Poor Prognosis in Oral Squamous Cell Carcinoma

(2015) Yueh-Min Lin et al.   PLoS One

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.

(2015) Sandra Cantilena et al.   Oncotarget

A Gutsy Task: Generating Intestinal Tissue from Human Pluripotent Stem Cells

(2013) Stacy R. Finkbeiner et al.   DIGESTIVE DISEASES AND SCIENCES

Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors

(2012) A. K. Shenoy et al.   CANCER RESEARCH

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

(2012) Sergei I. Grivennikov et al.   NATURE

Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival

(2010) Sylvia Adams et al.   BREAST CANCER RESEARCH AND TREATMENT

The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres

(2010) Shailender S Kanwar et al.   Molecular Cancer

LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine

(2009) Marie Isabelle Garcia et al.   DEVELOPMENTAL BIOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal Tumorigenesis

(2008) J. Zeilstra et al.   CANCER RESEARCH

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity

(2008) L. Vermeulen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA