MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
Authors
Keywords
-
Journal
Nature Communications
Volume 10, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-05-16
DOI
10.1038/s41467-019-09898-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAF V600E -Mutant Colorectal Cancer
- (2018) Ryan B. Corcoran et al. Cancer Discovery
- A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
- (2017) Felipe de Sousa e Melo et al. NATURE
- Visualization and targeting of LGR5+ human colon cancer stem cells
- (2017) Mariko Shimokawa et al. NATURE
- Cancer stem cells revisited
- (2017) Eduard Batlle et al. NATURE MEDICINE
- EGR-1 is an active transcription factor in TGF-β2-mediated small intestinal cell differentiation
- (2016) Man Zhang et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
- (2016) Stefka Tyanova et al. Nature Protocols
- Challenges of CRISPR/Cas9 applications for long non-coding RNA genes
- (2016) Ashish Goyal et al. NUCLEIC ACIDS RESEARCH
- Wnt signaling in cancer
- (2016) T Zhan et al. ONCOGENE
- The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells
- (2016) Dirk Fey et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- A bead-based western for high-throughput cellular signal transduction analyses
- (2016) Fridolin Treindl et al. Nature Communications
- Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
- (2016) Max A Horlbeck et al. eLife
- Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
- (2016) Carla S Verissimo et al. eLife
- Global cancer statistics, 2012
- (2015) Lindsey A. Torre et al. CA-A CANCER JOURNAL FOR CLINICIANS
- HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
- (2015) Paloma Ordóñez-Morán et al. CANCER CELL
- Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts
- (2015) Jurian Schuijers et al. Cell Stem Cell
- The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies
- (2015) Luping Lin et al. NATURE GENETICS
- Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids
- (2015) Mami Matano et al. NATURE MEDICINE
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- Tyrosine kinase inhibitor–induced CD70 expression mediates drug resistance in leukemia stem cells by activating Wnt signaling
- (2015) Carsten Riether et al. Science Translational Medicine
- A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms
- (2015) Monica Cojoc et al. SEMINARS IN CANCER BIOLOGY
- Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer
- (2015) Yibing Hu et al. PLoS One
- Evolution of the Cancer Stem Cell Model
- (2014) Antonija Kreso et al. Cell Stem Cell
- Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance
- (2014) Antonina V. Kurtova et al. NATURE
- E-CRISP: fast CRISPR target site identification
- (2014) Florian Heigwer et al. NATURE METHODS
- The clinical development of MEK inhibitors
- (2014) Yujie Zhao et al. Nature Reviews Clinical Oncology
- Targeting RAS–ERK signalling in cancer: promises and challenges
- (2014) Ahmed A. Samatar et al. NATURE REVIEWS DRUG DISCOVERY
- Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer
- (2014) E Lemieux et al. ONCOGENE
- Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3
- (2014) Chong Sun et al. Cell Reports
- RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells
- (2014) Simona Lamba et al. Cell Reports
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
- (2013) Baohui Chen et al. CELL
- Wnt signaling in adult intestinal stem cells and cancer
- (2013) Michaela Krausova et al. CELLULAR SIGNALLING
- Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
- (2013) Oksana Voloshanenko et al. Nature Communications
- RAB8B Is Required for Activity and Caveolar Endocytosis of LRP6
- (2013) Kubilay Demir et al. Cell Reports
- The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer
- (2012) T. Shimizu et al. CLINICAL CANCER RESEARCH
- Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial
- (2012) Jeffrey R Infante et al. LANCET ONCOLOGY
- A restricted cell population propagates glioblastoma growth after chemotherapy
- (2012) Jian Chen et al. NATURE
- Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
- (2012) Bon-Kyoung Koo et al. NATURE
- Active Wnt proteins are secreted on exosomes
- (2012) Julia Christina Gross et al. NATURE CELL BIOLOGY
- The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse
- (2011) Anna Merlos-Suárez et al. Cell Stem Cell
- Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
- (2011) Toshiro Sato et al. GASTROENTEROLOGY
- web cellHTS2: A web-application for the analysis of high-throughput screening data
- (2010) Oliver Pelz et al. BMC BIOINFORMATICS
- Mitogen-Activated Protein Kinases Promote WNT/ -Catenin Signaling via Phosphorylation of LRP6
- (2010) I. Cervenka et al. MOLECULAR AND CELLULAR BIOLOGY
- Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
- (2010) Louis Vermeulen et al. NATURE CELL BIOLOGY
- Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α
- (2010) Curtis A Thorne et al. Nature Chemical Biology
- Lentiviral Vectors to Probe and Manipulate the Wnt Signaling Pathway
- (2010) Christophe Fuerer et al. PLoS One
- EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin
- (2009) Haitao Ji et al. MOLECULAR CELL
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
- (2009) Shih-Min A. Huang et al. NATURE
- Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics
- (2009) Paul J Boersema et al. Nature Protocols
- The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/β-catenin pathway
- (2009) M Flahaut et al. ONCOGENE
- GSK3: a multifaceted kinase in Wnt signaling
- (2009) Dianqing Wu et al. TRENDS IN BIOCHEMICAL SCIENCES
- lumi: a pipeline for processing Illumina microarray
- (2008) P. Du et al. BIOINFORMATICS
- SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
- (2008) Min Jung Kim et al. FASEB JOURNAL
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now