CSCs in Breast Cancer—One Size Does Not Fit All: Therapeutic Advances in Targeting Heterogeneous Epithelial and Mesenchymal CSCs

A Sox2–Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells

(2019) Giacomo Domenici et al.   ONCOGENE

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody

(2019) Suping Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent therapeutic trends and promising targets in triple negative breast cancer

(2019) Soo-Yeon Hwang et al.   PHARMACOLOGY & THERAPEUTICS

New Insights into the Implication of Epigenetic Alterations in the EMT of Triple Negative Breast Cancer

(2019) Khaled et al.   Cancers

Co-Targeting Bulk Tumor and CSCs in Clinically Translatable TNBC Patient-Derived Xenografts via Combination Nanotherapy

(2019) Andrew Sulaiman et al.   MOLECULAR CANCER THERAPEUTICS

BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors

(2019) Hoon Kim et al.   Scientific Reports

Targeting Cancer Stem Cells in Triple-Negative Breast Cancer

(2019) Park et al.   Cancers

Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review

(2018) Ricardo L. B. Costa et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling

(2018) Ming Luo et al.   Cell Metabolism

REGγ Controls Hippo Signaling and Reciprocal NF-κB–YAP Regulation to Promote Colon Cancer

(2018) Qingwei Wang et al.   CLINICAL CANCER RESEARCH

Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer

(2018) Adam J. Camblin et al.   CLINICAL CANCER RESEARCH

Stat3/Oct-4/c-Myc signal circuit for regulating stemness-mediated doxorubicin resistance of triple-negative breast cancer cells and inhibitory effects of WP1066

(2018) Cong-Cong Cheng et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis

(2018) Yan Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Dual inhibition of Wnt and Yes-associated protein signaling retards the growth of triple-negative breast cancer in both mesenchymal and epithelial states

(2018) Andrew Sulaiman et al.   Molecular Oncology

5-Fluorouracil may enrich cancer stem cells in canine mammary tumor cells in�vitro

(2018) Bin Zhou et al.   Oncology Letters

RANTES and IL-6 cooperate in inducing a more aggressive phenotype in breast cancer cells

(2018) Marianna Gallo et al.   Oncotarget

IMP3 Stabilization of WNT5B mRNA Facilitates TAZ Activation in Breast Cancer

(2018) Sanjoy Samanta et al.   Cell Reports

Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells

(2018) Ahmed El-Badawy et al.   Biology Open

NF-kappaB: Two Sides of the Same Coin

(2018) Bruno Pires et al.   Genes

Hypoxia-Inducible Factor-1α Activity as a Switch for Glioblastoma Responsiveness to Temozolomide

(2018) Alessia Lo Dico et al.   Frontiers in Oncology

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The EZH2- H3K27me3-DNMT1 complex orchestrates epigenetic silencing of the wwc1 gene, a Hippo/YAP pathway upstream effector, in breast cancer epithelial cells

(2018) Xiong Liu et al.   CELLULAR SIGNALLING

363TiPPhase Ib/IIa study of RX-5902, a novel orally bioavailable inhibitor of phosphorylated P68, which prevents nuclear β-catenin translocation in patients with triple negative breast cancer

(2018) J R Diamond et al.   ANNALS OF ONCOLOGY

The WNT10B network is associated with survival and metastases in chemoresistant triple-negative breast cancer

(2018) Ikbale El Ayachi et al.   CANCER RESEARCH

Tumour heterogeneity and metastasis at single-cell resolution

(2018) Devon A. Lawson et al.   NATURE CELL BIOLOGY

Unbalanced YAP–SOX9 circuit drives stemness and malignant progression in esophageal squamous cell carcinoma

(2018) Lianghai Wang et al.   ONCOGENE

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment

(2018) Federico Bocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

(2018) Binghua Li et al.   EBioMedicine

CBP/β-Catenin/FOXM1 Is a Novel Therapeutic Target in Triple Negative Breast Cancer

(2018) Alexander Ring et al.   Cancers

Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice

(2017) Han-Byul Kim et al.   GASTROENTEROLOGY

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

(2017) Hyunju Oh et al.   IMMUNITY

Targeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be Overcome

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Induction of interleukin-1β by mouse mammary tumor irradiation promotes triple negative breast cancer cells invasion and metastasis development

(2017) Gina Bouchard et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Catching moving targets: cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention

(2017) Claudia Gasch et al.   Molecular Cancer

Intra-tumor heterogeneity from a cancer stem cell perspective

(2017) Pramudita R. Prasetyanti et al.   Molecular Cancer

Upholding a role for EMT in breast cancer metastasis

(2017) Xin Ye et al.   NATURE

Fischer et al. reply

(2017) Kari R. Fischer et al.   NATURE

Upholding a role for EMT in pancreatic cancer metastasis

(2017) Nicole M. Aiello et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

An autocrine inflammatory forward-feedback loop after chemotherapy withdrawal facilitates the repopulation of drug-resistant breast cancer cells

(2017) Deyong Jia et al.   Cell Death & Disease

Dual inhibition of histone deacetylases and phosphoinositide 3-kinase enhances therapeutic activity against B cell lymphoma

(2017) Patrizia Mondello et al.   Oncotarget

Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma

(2017) Fuchen Liu et al.   Oncotarget

Bridging the divide: preclinical research discrepancies between triple-negative breast cancer cell lines and patient tumors

(2017) Andrew Sulaiman et al.   Oncotarget

Wnt signaling in triple-negative breast cancer

(2017) SÖ-G Pohl et al.   Oncogenesis

The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells

(2017) Priyanka Aryappalli et al.   Frontiers in Oncology

Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis

(2017) Wenzhe Li et al.   Scientific Reports

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Efficacy of poly(ADP-ribose) polymerase inhibitor olaparib against head and neck cancer cells: Predictions of drug sensitivity based on PAR-p53-NF-κB interactions

(2016) M. Kwon et al.   EUROPEAN JOURNAL OF CANCER

A multicenter phase II study of istiratumab (MM-141) plus nab-paclitaxel (A) and gemcitabine (G) in metastatic pancreatic cancer (MPC).

(2016) Andrew H. Ko et al.   JOURNAL OF CLINICAL ONCOLOGY

US cancer institute to overhaul tumour cell lines

(2016) Heidi Ledford   NATURE

Expression of Hypoxia-Inducible Factor 1α in Invasive Breast Cancer with Metastasis to Lymph Nodes: Correlation with Steroid Receptors, HER2 and EPO-R

(2016) Anna Badowska-Kozakiewicz et al.   Advances in Clinical and Experimental Medicine

The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level

(2016) Natthakan Thongon et al.   Oncotarget

Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling

(2016) Chia-Wen Hsu et al.   Oncotarget

HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity

(2016) Ching-Ying Kuo et al.   Oncotarget

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

Mammary Development and Breast Cancer: A Wnt Perspective

(2016) Qing Yu et al.   Cancers

NF-κB and HIF crosstalk in immune responses

(2015) Laura D'Ignazio et al.   FEBS Journal

Effect of MM-141 on gemcitabine and nab-paclitaxel potentiation in preclinical models of pancreatic cancer through induction of IGF-1R and ErbB3 degradation.

(2015) Emily Pace et al.   JOURNAL OF CLINICAL ONCOLOGY

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

(2015) Chun-Han Lin et al.   MOLECULAR BIOLOGY OF THE CELL

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells

(2015) YANLI YUAN et al.   Molecular Medicine Reports

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

(2015) Huimin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

(2015) Haiquan Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness

(2015) Tackhoon Kim et al.   Nature Communications

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor

(2015) Huey-En Tzeng et al.   Oncotarget

Cardamonin reduces chemotherapy-enriched breast cancer stem-like cells in vitro and in vivo

(2015) Deyong Jia et al.   Oncotarget

Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endocrine therapy in estrogen receptor-positive breast

(2015) Xiaoqing Jia et al.   Oncotarget

Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells

(2015) Bin You et al.   Oncotarget

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation

(2015) Ze-Yi Zheng et al.   Cell Reports

β-Catenin Is Required for the Tumorigenic Behavior of Triple-Negative Breast Cancer Cells

(2015) Jinhua Xu et al.   PLoS One

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway

(2014) Y. Zhao et al.   CANCER RESEARCH

Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models

(2014) Yasuhiro Funahashi et al.   CANCER SCIENCE

Interaction of omeprazole and Helicobacter pylori-induced nuclear factor-κB activation and mediators in gastric epithelial cells

(2014) Yen-Chun Peng et al.   Journal of the Chinese Medical Association

Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression

(2014) Katja Handschick et al.   MOLECULAR CELL

Clonal evolution in breast cancer revealed by single nucleus genome sequencing

(2014) Yong Wang et al.   NATURE

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2

(2014) D Zhao et al.   ONCOGENE

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

(2014) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia

(2014) Catherine J. Kelly et al.   RADIOTHERAPY AND ONCOLOGY

Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis

(2014) Dinesh Vyas et al.   OncoTargets and Therapy

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Wnt signaling in triple negative breast cancer is associated with metastasis

(2013) Nandini Dey et al.   BMC CANCER

Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells

(2013) P Liu et al.   BRITISH JOURNAL OF CANCER

Overview: Cellular plasticity, cancer stem cells and metastasis

(2013) Wael M. ElShamy et al.   CANCER LETTERS

A Renewable Tissue Resource of Phenotypically Stable, Biologically and Ethnically Diverse, Patient-Derived Human Breast Cancer Xenograft Models

(2013) X. Zhang et al.   CANCER RESEARCH

Tumor Cells Upregulate Normoxic HIF-1  in Response to Doxorubicin

(2013) Y. Cao et al.   CANCER RESEARCH

Growth of Triple-Negative Breast Cancer Cells Relies upon Coordinate Autocrine Expression of the Proinflammatory Cytokines IL-6 and IL-8

(2013) Z. C. Hartman et al.   CANCER RESEARCH

Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells

(2013) Seog-Young Kim et al.   CELLULAR SIGNALLING

WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer

(2013) Peter Wend et al.   EMBO Molecular Medicine

NF-κB: roles and regulation in different CD4+T-cell subsets

(2013) Hyunju Oh et al.   IMMUNOLOGICAL REVIEWS

Cancer stem cells maintain a hierarchy of differentiation by creating their niche

(2013) Shuichi Matsuda et al.   INTERNATIONAL JOURNAL OF CANCER

SOX9 Regulates Low Density Lipoprotein Receptor-related Protein 6 (LRP6) and T-cell Factor 4 (TCF4) Expression and Wnt/β-catenin Activation in Breast Cancer

(2013) Hongyun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Patient-derived xenografts, the cancer stem cell paradigm and cancer pathobiology in the 21st century

(2013) Samuel A Williams et al.   LABORATORY INVESTIGATION

PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation

(2013) Hae-Yun Jung et al.   MOLECULAR CELL

Oncolytic Adenovirus Expressing IL-23 and p35 Elicits IFN-γ- and TNF-α-Co-Producing T Cell-Mediated Antitumor Immunity

(2013) Il-Kyu Choi et al.   PLoS One

NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype

(2013) Mizuki Yamamoto et al.   Nature Communications

Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer

(2013) Eva J. Vlug et al.   CELLULAR ONCOLOGY

EMT in carcinoma progression and dissemination: Facts, unanswered questions, and clinical considerations

(2012) Jeremy Bastid   CANCER AND METASTASIS REVIEWS

Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment

(2012) Olga Frolova et al.   CANCER BIOLOGY & THERAPY

Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling

(2012) D. Horst et al.   CANCER RESEARCH

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Significance of CD44 and CD24 as Cancer Stem Cell Markers: An Enduring Ambiguity

(2012) Appalaraju Jaggupilli et al.   Clinical & Developmental Immunology

Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib

(2012) A. Lachenmayer et al.   CLINICAL CANCER RESEARCH

Sorafenib Inhibits Hypoxia-Inducible Factor-1  Synthesis: Implications for Antiangiogenic Activity in Hepatocellular Carcinoma

(2012) L.-p. Liu et al.   CLINICAL CANCER RESEARCH

Cutting Edge: Regulatory T Cells Selectively Attenuate, Not Terminate, T Cell Signaling by Disrupting NF- B Nuclear Accumulation in CD4 T Cells

(2012) Y.-H. Huang et al.   JOURNAL OF IMMUNOLOGY

Expression of Dickkopf-1 and Beta-Catenin Related to the Prognosis of Breast Cancer Patients with Triple Negative Phenotype

(2012) Wen-Huan Xu et al.   PLoS One

Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression

(2012) Holger Buss et al.   PLoS One

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling

(2011) Chun-Ju Chang et al.   CANCER CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform

(2011) Paola Marcato et al.   CELL CYCLE

NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice

(2011) Susan E. Murray et al.   JOURNAL OF CLINICAL INVESTIGATION

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Stratification of Triple-Negative Breast Cancers

(2011) C. M. Perou   ONCOLOGIST

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

(2010) Andrey I. Khramtsov et al.   AMERICAN JOURNAL OF PATHOLOGY

Heterogeneity for Stem Cell-Related Markers According to Tumor Subtype and Histologic Stage in Breast Cancer

(2010) S. Y. Park et al.   CLINICAL CANCER RESEARCH

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

(2010) Christophe Ginestier et al.   JOURNAL OF CLINICAL INVESTIGATION

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

(2010) Felipe C Geyer et al.   MODERN PATHOLOGY

MS-275 Sensitizes TRAIL-Resistant Breast Cancer Cells, Inhibits Angiogenesis and Metastasis, and Reverses Epithelial-Mesenchymal Transition In vivo

(2010) R. K. Srivastava et al.   MOLECULAR CANCER THERAPEUTICS

Anticancer drug development: the grand challenges

(2010) William N. Hait   NATURE REVIEWS DRUG DISCOVERY

Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration

(2009) Wolfram Goessling et al.   CELL

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

c-Rel is required for the development of thymic Foxp3+CD4 regulatory T cells

(2009) Iwao Isomura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

(2008) S. W. Chan et al.   CANCER RESEARCH

The effect of azacitidine on interleukin-6 signaling and nuclear factor- B activation and its in vitro and in vivo activity against multiple myeloma

(2008) T. Khong et al.   HAEMATOLOGICA

Differential Role of the Transcription Factor NF-κB in Selection and Survival of CD4+ and CD8+ Thymocytes

(2008) Eijiro Jimi et al.   IMMUNITY

Response to Neoadjuvant Therapy and Long-Term Survival in Patients With Triple-Negative Breast Cancer

(2008) Cornelia Liedtke et al.   JOURNAL OF CLINICAL ONCOLOGY

Requirement of hypoxia-inducible factor-1  down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab

(2008) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

(2008) R. Sullivan et al.   MOLECULAR CANCER THERAPEUTICS