EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity

3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells

(2022) Zhiqiang Wang et al.   Cell Stem Cell

CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development

(2022) Edroaldo Lummertz da Rocha et al.   NATURE CELL BIOLOGY

NK cell-based cancer immunotherapy: from basic biology to clinical development

(2021) Sizhe Liu et al.   Journal of Hematology & Oncology

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

(2021) Shoichi Iriguchi et al.   Nature Communications

EZH1/2 Inhibitors Favor ILC3 Development from Human HSPC-CD34+ Cells

(2021) Laura Damele et al.   Cancers

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

(2021) Nathan D. Mathewson et al.   CELL

Interferon regulatory factor 4 controls effector functions of CD8+ memory T cells

(2021) Aenne Harberts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells

(2021) Bo Wang et al.   Nature Biomedical Engineering

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

(2021) Karrune V. Woan et al.   Cell Stem Cell

BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells

(2021) Hyungseok Seo et al.   NATURE IMMUNOLOGY

DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system

(2021) Ashton C. Trotman-Grant et al.   Nature Communications

Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2

(2021) Rebecca A. Soto et al.   Stem Cell Reports

An NK-like CAR T cell transition in CAR T cell dysfunction

(2021) Charly R. Good et al.   CELL

Efficient and precise single-cell reference atlas mapping with Symphony

(2021) Joyce B. Kang et al.   Nature Communications

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

(2020) Enli Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development

(2020) Carissa Dege et al.   DEVELOPMENTAL CELL

Tumor fibroblast-derived FGF2 regulates expression of SPRY1 in esophageal tumor-infiltrating T cells and plays a role in T cell exhaustion

(2020) Qing-yun Chen et al.   CANCER RESEARCH

Next-generation cell therapies: the emerging role of CAR-NK cells

(2020) Rafet Basar et al.   Hematology-American Society of Hematology Education Program

Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells

(2019) Amélie Montel-Hagen et al.   Cell Stem Cell

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Chimeric antigen receptor T cell persistence and memory cell formation

(2019) Alexander D McLellan et al.   IMMUNOLOGY AND CELL BIOLOGY

Generation of hypoimmunogenic human pluripotent stem cells

(2019) Xiao Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

(2019) Nicolas Istaces et al.   Nature Communications

Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia

(2019) Jeffrey M. Granja et al.   NATURE BIOTECHNOLOGY

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

The Transcription Factor Runx3 Establishes Chromatin Accessibility of cis -Regulatory Landscapes that Drive Memory Cytotoxic T Lymphocyte Formation

(2018) Dapeng Wang et al.   IMMUNITY

Long Terminal Repeat CRISPR-CAR-Coupled “Universal” T Cells Mediate Potent Anti-leukemic Effects

(2018) Christos Georgiadis et al.   MOLECULAR THERAPY

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

(2018) Keishi Adachi et al.   NATURE BIOTECHNOLOGY

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Reconstruction of complex single-cell trajectories using CellRouter

(2018) Edroaldo Lummertz da Rocha et al.   Nature Communications

Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System

(2018) Raul Vizcardo et al.   Cell Reports

Regulation of embryonic haematopoietic multipotency by EZH1

(2018) Linda T. Vo et al.   NATURE

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

(2018) Joseph A. Fraietta et al.   NATURE

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

(2018) Sarwish Rafiq et al.   NATURE BIOTECHNOLOGY

From Pluripotent Stem Cells to T cells

(2018) Amélie Montel-Hagen et al.   EXPERIMENTAL HEMATOLOGY

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

(2018) Kendall R. Sanson et al.   Nature Communications

IRF9 Prevents CD8 + T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection

(2017) Magdalena Huber et al.   JOURNAL OF VIROLOGY

Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells

(2017) Daniel T. MacLeod et al.   MOLECULAR THERAPY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Haematopoietic stem and progenitor cells from human pluripotent stem cells

(2017) Ryohichi Sugimura et al.   NATURE

Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids

(2017) Christopher S Seet et al.   NATURE METHODS

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1

(2017) Shreya Shukla et al.   NATURE METHODS

Assessment of engineered cells using CellNet and RNA-seq

(2017) Arthur H Radley et al.   Nature Protocols

Generation of “Off-the-Shelf” Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells

(2017) Jieming Zeng et al.   Stem Cell Reports

Regeneration of CD8αβ T Cells from T-cell–Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity

(2016) Takuya Maeda et al.   CANCER RESEARCH

CAR-T Cell Therapies From the Transfusion Medicine Perspective

(2016) Andrew Fesnak et al.   TRANSFUSION MEDICINE REVIEWS

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

(2015) D Sommermeyer et al.   LEUKEMIA

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages

(2015) Andrea Ditadi et al.   NATURE CELL BIOLOGY

Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8+ T cells

(2015) Valérie Martinet et al.   Nature Communications

CellNet: Network Biology Applied to Stem Cell Engineering

(2014) Patrick Cahan et al.   CELL

Technical Advance: Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells

(2014) Mirelle J. A. J. Huijskens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IL-12-secreting CD19-targeted cord blood-derived T cells for the immunotherapy of B-cell acute lymphoblastic leukemia

(2014) H J Pegram et al.   LEUKEMIA

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

(2014) Makoto Kurachi et al.   NATURE IMMUNOLOGY

Broad T-Cell Receptor Repertoire in T-Lymphocytes Derived from Human Induced Pluripotent Stem Cells

(2014) Chia-Wei Chang et al.   PLoS One

Regeneration of Human Tumor Antigen-Specific T Cells from iPSCs Derived from Mature CD8 + T Cells

(2013) Raul Vizcardo et al.   Cell Stem Cell

Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation

(2013) Toshinobu Nishimura et al.   Cell Stem Cell

Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors

(2013) Sergei Doulatov et al.   Cell Stem Cell

Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy

(2013) Maria Themeli et al.   NATURE BIOTECHNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy

(2013) David A. Knorr et al.   Stem Cells Translational Medicine

Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: Differing impact on CD8 T cell phenotype and responsiveness to restimulation

(2010) Yixin Li et al.   Journal of Translational Medicine

Intracellular Bacterial Vectors That Induce CD8+ T Cells with Similar Cytolytic Abilities but Disparate Memory Phenotypes Provide Contrasting Tumor Protection

(2009) F. C. Stark et al.   CANCER RESEARCH

Generation of T Cells from Human Embryonic Stem Cell-Derived Hematopoietic Zones

(2009) F. Timmermans et al.   JOURNAL OF IMMUNOLOGY

Doubting the TCR Coreceptor Function of CD8αα

(2008) Hilde Cheroutre et al.   IMMUNITY

EZH1 Mediates Methylation on Histone H3 Lysine 27 and Complements EZH2 in Maintaining Stem Cell Identity and Executing Pluripotency

(2008) Xiaohua Shen et al.   MOLECULAR CELL

Lineage Diversion of T Cell Receptor Transgenic Thymocytes Revealed by Lineage Fate Mapping

(2008) Takeshi Egawa et al.   PLoS One