Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids

Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies

(2015) Laurent Poirot et al.   CANCER RESEARCH

New Cell Sources for T Cell Engineering and Adoptive Immunotherapy

(2015) Maria Themeli et al.   Cell Stem Cell

A discrete population of IFN λ-expressing BDCA3hi dendritic cells is present in human thymus

(2015) Víctor G Martínez et al.   IMMUNOLOGY AND CELL BIOLOGY

Long non-coding RNA profiling of human lymphoid progenitor cells reveals transcriptional divergence of B cell and T cell lineages

(2015) David Casero et al.   NATURE IMMUNOLOGY

HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice

(2014) E. H. Gschweng et al.   CANCER RESEARCH

TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer

(2014) B Berdien et al.   GENE THERAPY

Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions

(2014) Paul F. Robbins et al.   JOURNAL OF IMMUNOLOGY

Technical Advance: Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells

(2014) Mirelle J. A. J. Huijskens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Engineering the Human Thymic Microenvironment to Support Thymopoiesis In Vivo

(2014) Brile Chung et al.   STEM CELLS

Exploiting the curative potential of adoptive T-cell therapy for cancer

(2013) Christian S. Hinrichs et al.   IMMUNOLOGICAL REVIEWS

Immunotherapy with TCR-Redirected T Cells: Comparison of TCR-Transduced and TCR-Engineered Hematopoietic Stem Cell-Derived T Cells

(2013) L. Starck et al.   JOURNAL OF IMMUNOLOGY

In vitro generation of mature, naive antigen-specific CD8+ T cells with a single T-cell receptor by agonist selection

(2013) S Snauwaert et al.   LEUKEMIA

Allelic Exclusion and Peripheral Reconstitution by TCR Transgenic T Cells Arising From Transduced Human Hematopoietic Stem/Progenitor Cells

(2013) Francesca Giannoni et al.   MOLECULAR THERAPY

Introduction of Exogenous T-cell Receptors Into Human Hematopoietic Progenitors Results in Exclusion of Endogenous T-cell Receptor Expression

(2013) Dimitrios N Vatakis et al.   MOLECULAR THERAPY

Vitamin C Promotes Maturation of T-Cells

(2012) Jared Manning et al.   ANTIOXIDANTS & REDOX SIGNALING

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR

(2012) H. Torikai et al.   BLOOD

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin

(2012) Lisa A Kohn et al.   NATURE IMMUNOLOGY

Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature

(2011) Génève Awong et al.   BMC IMMUNOLOGY

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

(2011) M. De Smedt et al.   HAEMATOLOGICA

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells

(2009) G. Awong et al.   BLOOD

A novel method for the generation of reaggregated organotypic cultures that permits juxtaposition of defined cell populations

(2009) Julie M. Sheridan et al.   GENESIS

Functionally Mature CD4 and CD8 TCR   Cells Are Generated in OP9-DL1 Cultures from Human CD34+ Hematopoietic Cells

(2009) S. Van Coppernolle et al.   JOURNAL OF IMMUNOLOGY

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity

(2009) C. S. Hinrichs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA