Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1

A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production

(2016) Emanuel Joseph Paul Nazareth et al.   Stem Cell Reports

Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies

(2015) Laurent Poirot et al.   CANCER RESEARCH

Lymphoid Regeneration from Gene-Corrected SCID-X1 Subject-Derived iPSCs

(2015) Tushar Menon et al.   Cell Stem Cell

In Vitro T-Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination

(2015) Michelle J. Smith et al.   STEM CELLS

A stromal cell free culture system generates mouse pro-T cells that can reconstitute T-cell compartments in vivo

(2014) Nadine Gehre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Technical Advance: Ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells

(2014) Mirelle J. A. J. Huijskens et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

(2014) I. Fares et al.   SCIENCE

Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture

(2013) G. Awong et al.   BLOOD

Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling

(2013) E. Csaszar et al.   BLOOD

Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1

(2013) Marie Blanke Andrawes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of Functional, Antigen-Specific CD8+ Human T Cells from Cord Blood Stem Cells Using Exogenous Notch and Tetramer-TCR Signaling

(2013) Irina Fernandez et al.   STEM CELLS

Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches

(2012) Paul P.C. Roozen et al.   Annals of the New York Academy of Sciences

Synergistic, Context-Dependent, and Hierarchical Functions of Epithelial Components in Thymic Microenvironments

(2012) Lesly Calderón et al.   CELL

Rapid Expansion of Human Hematopoietic Stem Cells by Automated Control of Inhibitory Feedback Signaling

(2012) Elizabeth Csaszar et al.   Cell Stem Cell

Intrathymic IL-7: The where, when, and why of IL-7 signaling during T cell development

(2012) Changwan Hong et al.   SEMINARS IN IMMUNOLOGY

Human T-Lymphoid Progenitors Generated in a Feeder-Cell-Free Delta-Like-4 Culture System Promote T-Cell Reconstitution in NOD/SCID/γc−/− Mice

(2012) Christian Reimann et al.   STEM CELLS

Immune Reconstitution after Double Umbilical Cord Blood Stem Cell Transplantation: Comparison with Unrelated Peripheral Blood Stem Cell Transplantation

(2011) Caron A. Jacobson et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/−mice improves engraftment of human hematopoietic cells in humanized mice

(2011) Till Strowig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outcomes, infections, and immune reconstitution after double cord blood transplantation in patients with high-risk hematological diseases

(2011) A. Ruggeri et al.   Transplant Infectious Disease

Regulatory gene network circuits underlying T cell development from multipotent progenitors

(2011) Hao Yuan Kueh et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes

(2010) M. Mohtashami et al.   JOURNAL OF IMMUNOLOGY

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

(2010) Colleen Delaney et al.   NATURE MEDICINE

An Essential Developmental Checkpoint for Production of the T Cell Lineage

(2010) T. Ikawa et al.   SCIENCE

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells

(2009) G. Awong et al.   BLOOD

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

(2009) Michelle L. Janas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Delta-like 4 is indispensable in thymic environment specific for T cell development

(2008) Katsuto Hozumi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment

(2008) Ute Koch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors

(2008) Johannes L Zakrzewski et al.   NATURE BIOTECHNOLOGY