Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2

Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis

(2020) Jiahuan Chen et al.   Cell Death & Disease

Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

(2020) Cristina Porcheri et al.   EMBO JOURNAL

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

(2020) Peng Gao et al.   GENES & DEVELOPMENT

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

(2020) Jenna M. Frame et al.   DEVELOPMENTAL CELL

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium

(2019) Florian Bonkhofer et al.   Nature Communications

Regulation of embryonic haematopoietic multipotency by EZH1

(2018) Linda T. Vo et al.   NATURE

Arterial identity of hemogenic endothelium: a key to unlock definitive hematopoietic commitment in hPSC cultures

(2018) Igor I. Slukvin et al.   EXPERIMENTAL HEMATOLOGY

The molecular basis of endothelial cell plasticity

(2017) Elisabetta Dejana et al.   Nature Communications

Engineering Hematopoietic Stem Cells: Lessons from Development

(2016) R. Grant Rowe et al.   Cell Stem Cell

Complex regulation of HSC emergence by the Notch signaling pathway

(2016) Emerald Butko et al.   DEVELOPMENTAL BIOLOGY

Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells

(2016) Rui Monteiro et al.   DEVELOPMENTAL CELL

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation

(2016) Debbie K. Goode et al.   DEVELOPMENTAL CELL

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta

(2016) Inn-Inn Chen et al.   Scientific Reports

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2

(2016) Bilge San et al.   Scientific Reports

Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production

(2016) Mauricio Cortes et al.   Cell Reports

Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo

(2015) E. Butko et al.   DEVELOPMENT

Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions

(2015) Jian Xu et al.   MOLECULAR CELL

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages

(2015) Andrea Ditadi et al.   NATURE CELL BIOLOGY

Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition

(2015) Carlos O. Lizama et al.   Nature Communications

Notch signal strength controls cell fate in the haemogenic endothelium

(2015) Leonor Gama-Norton et al.   Nature Communications

Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo

(2015) Kathleen E. McGrath et al.   Cell Reports

Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence

(2014) Raquel Espín-Palazón et al.   CELL

Distinct Notch signaling outputs pattern the developing arterial system

(2014) A. Quillien et al.   DEVELOPMENT

Estrogen Defines the Dorsal-Ventral Limit of VEGF Regulation to Specify the Location of the Hemogenic Endothelial Niche

(2014) Kelli J. Carroll et al.   DEVELOPMENTAL CELL

Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration

(2014) L. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythro-myeloid progenitors: “Definitive” hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells

(2013) Jenna M. Frame et al.   BLOOD CELLS MOLECULES AND DISEASES

Gata2cis-element is required for hematopoietic stem cell generation in the mammalian embryo

(2013) Xin Gao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A network of epigenetic regulators guides developmental haematopoiesis in vivo

(2013) Hsuan-Ting Huang et al.   NATURE CELL BIOLOGY

The role of HOX genes in normal hematopoiesis and acute leukemia

(2012) R A Alharbi et al.   LEUKEMIA

Polycomb Protein Ezh1 Promotes RNA Polymerase II Elongation

(2011) Kambiz Mousavi et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Fate Tracing Reveals the Endothelial Origin of Hematopoietic Stem Cells

(2008) Ann C. Zovein et al.   Cell Stem Cell

Ezh1 and Ezh2 Maintain Repressive Chromatin through Different Mechanisms

(2008) Raphael Margueron et al.   MOLECULAR CELL