Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies

Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation

(2021) Adva Hadar et al.   MOLECULAR PSYCHIATRY

miR-19a/b-3p promotes inflammation during cerebral ischemia/reperfusion injury via SIRT1/FoxO3/SPHK1 pathway

(2021) Feng Zhou et al.   Journal of Neuroinflammation

Microbiota changes associated with ADNP deficiencies: rapid indicators for NAP (CP201) treatment of the ADNP syndrome and beyond

(2020) Oxana Kapitansky et al.   JOURNAL OF NEURAL TRANSMISSION

Whole-Brain Monosynaptic Inputs to Hypoglossal Motor Neurons in Mice

(2020) Han Guo et al.   Neuroscience Bulletin

Deciphering the Enigma: NAP (CP201) the Active ADNP Drug Candidate Enters Cells by Dynamin-Associated Endocytosis

(2020) Yanina Ivashko-Pachima et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling

(2020) Xiaoyun Sun et al.   Nature Communications

Tauopathy in the young autistic brain: novel biomarker and therapeutic target

(2020) Iris Grigg et al.   Translational Psychiatry

Sex differences in Alzheimer’s-related Tau biomarkers and a mediating effect of testosterone

(2020) Erin E. Sundermann et al.   Biology of Sex Differences

P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

(2020) Kathleen M. Farmer et al.   Acta Neuropathologica Communications

Sex Differences in Biological Processes and Nitrergic Signaling in Mouse Brain

(2020) Igor Khaliulin et al.   Biomedicines

Age and Sex-Dependent ADNP Regulation of Muscle Gene Expression Is Correlated with Motor Behavior: Possible Feedback Mechanism with PACAP

(2020) Oxana Kapitansky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sex-and Region-Dependent Expression of the Autism-Linked ADNP Correlates with Social- and Speech-Related Genes in the Canary Brain

(2020) Gal Hacohen-Kleiman et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Electroacupuncture Involved in Motor Cortex and Hypoglossal Neural Control to Improve Voluntary Swallowing of Poststroke Dysphagia Mice

(2020) Shuai Cui et al.   NEURAL PLASTICITY

Single Cell ADNP Predictive of Human Muscle Disorders: Mouse Knockdown Results in Muscle Wasting

(2020) Oxana Kapitansky et al.   Cells

The ADNP Syndrome and CP201 (NAP) Potential and Hope

(2020) Illana Gozes   Frontiers in Neurology

Transcriptional Profiling Reveals Ribosome Biogenesis, Microtubule Dynamics and Expression of Specific lncRNAs to be Part of a Common Response to Cell-Penetrating Peptides

(2020) Tomas Venit et al.   Biomolecules

DeepSqueak: a deep learning-based system for detection and analysis of ultrasonic vocalizations

(2019) Kevin R. Coffey et al.   NEUROPSYCHOPHARMACOLOGY

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse

(2019) Shlomo Sragovich et al.   Translational Psychiatry

Cellular and animal models of skin alterations in the autism-related ADNP syndrome

(2019) Pilar Mollinedo et al.   Scientific Reports

Motor cortical control of vocal interaction in neotropical singing mice

(2019) Daniel E. Okobi et al.   SCIENCE

Developmental Phenotype of the Rare Case of DJ Caused by a Unique ADNP Gene De Novo Mutation

(2019) Joseph Levine et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

High specificity of widely used phospho‐tau antibodies validated using a quantitative whole‐cell based assay

(2019) Dan Li et al.   JOURNAL OF NEUROCHEMISTRY

Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

(2019) Mingyu Xu et al.   Frontiers in Psychiatry

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

(2019) Andrea Ganna et al.   SCIENCE

The autism-mutated ADNP plays a key role in stress response

(2019) Shlomo Sragovich et al.   Translational Psychiatry

Discovery of autism/intellectual disability somatic mutations in Alzheimer's brains: mutated ADNP cytoskeletal impairments and repair as a case study

(2019) Yanina Ivashko-Pachima et al.   MOLECULAR PSYCHIATRY

Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders

(2019) Tychele N. Turner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

OUP accepted manuscript

(2018)   BIOINFORMATICS

Clinical Presentation of a Complex Neurodevelopmental Disorder Caused by Mutations in ADNP

(2018) Anke Van Dijck et al.   BIOLOGICAL PSYCHIATRY

Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders

(2018) Laure Tabouy et al.   BRAIN BEHAVIOR AND IMMUNITY

Mutations in ADNP affect expression and subcellular localization of the protein

(2018) Elisa Cappuyns et al.   CELL CYCLE

SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease

(2018) A. Hadar et al.   Scientific Reports

Stem Cell Transcription Factor FoxO Controls Microbiome Resilience in Hydra

(2018) Benedikt M. Mortzfeld et al.   Frontiers in Microbiology

The Impact of a Novel Apolipoprotein E and Amyloid-β Protein Precursor-Interacting Protein on the Production of Amyloid-β

(2018) Paul C.R. Hopkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome

(2018) Gal Hacohen-Kleiman et al.   JOURNAL OF CLINICAL INVESTIGATION

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes

(2018) Veronika Ostapcuk et al.   NATURE

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

(2018) Iris Schäffner et al.   NEURON

Effects of FOXO3 Polymorphisms on Survival to Extreme Longevity in Four Centenarian Studies

(2017) Harold Bae et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

ADNP/NAP dramatically increase microtubule end-binding protein–Tau interaction: a novel avenue for protection against tauopathy

(2017) Y Ivashko-Pachima et al.   MOLECULAR PSYCHIATRY

Sexual dimorphism of AMBRA1-related autistic features in human and mouse

(2017) M Mitjans et al.   Translational Psychiatry

The Eight and a Half Year Journey of Undiagnosed AD: Gene Sequencing and Funding of Advanced Genetic Testing Has Led to Hope and New Beginnings

(2017) Illana Gozes et al.   Frontiers in Endocrinology

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory

(2016) N Amram et al.   MOLECULAR PSYCHIATRY

Maternal Deprivation Influences Pup Ultrasonic Vocalizations of C57BL/6J Mice

(2016) Xiaowen Yin et al.   PLoS One

Administration of Non-Absorbable Antibiotics to Pregnant Mice to Perturb the Maternal Gut Microbiota Is Associated with Alterations in Offspring Behavior

(2016) Shiro Tochitani et al.   PLoS One

Rapid and Objective Assessment of Neural Function in Autism Spectrum Disorder Using Transient Visual Evoked Potentials

(2016) Paige M. Siper et al.   PLoS One

Using Gene Ontology to describe the role of the neurexin-neuroligin-SHANK complex in human, mouse and rat and its relevance to autism

(2015) Sejal Patel et al.   BMC BIOINFORMATICS

The Compassionate Side of Neuroscience: Tony Sermone’s Undiagnosed Genetic Journey—ADNP Mutation

(2015) Illana Gozes et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dendritic spine dysgenesis in autism related disorders

(2015) Mary Phillips et al.   NEUROSCIENCE LETTERS

Risperidone and NAP protect cognition and normalize gene expression in a schizophrenia mouse model

(2015) Sinaya Vaisburd et al.   Scientific Reports

Early handling and repeated cross-fostering have opposite effect on mouse emotionality

(2015) Alessandra Luchetti et al.   Frontiers in Behavioral Neuroscience

Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer’s pathologies

(2015) A Malishkevich et al.   Translational Psychiatry

New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophrenia

(2014) Avia Merenlender-Wagner et al.   Autophagy

The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins

(2014) S Oz et al.   MOLECULAR PSYCHIATRY

A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP

(2014) Céline Helsmoortel et al.   NATURE GENETICS

Heterozygous Ambra1 Deficiency in Mice: A Genetic Trait with Autism-Like Behavior Restricted to the Female Gender

(2014) Ekrem Dere et al.   Frontiers in Behavioral Neuroscience

The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

(2013) A.R. Esteves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy has a key role in the pathophysiology of schizophrenia

(2013) A Merenlender-Wagner et al.   MOLECULAR PSYCHIATRY

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy

(2013) S Quraishe et al.   MOLECULAR PSYCHIATRY

NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: Protection against impairments in axonal transport

(2013) Yan Jouroukhin et al.   NEUROBIOLOGY OF DISEASE

Davunetide: a review of safety and efficacy data with a focus on neurodegenerative diseases

(2013) Bruce H Morimoto et al.   Expert Review of Clinical Pharmacology

End-binding protein 1 controls signal propagation from the T cell receptor

(2012) Noa B Martín-Cófreces et al.   EMBO JOURNAL

Time Course and Spatial Profile of Nogo-A Expression in Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice

(2012) Paschalis Theotokis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The ADNP Derived Peptide, NAP Modulates the Tubulin Pool: Implication for Neurotrophic and Neuroprotective Activities

(2012) Saar Oz et al.   PLoS One

Mechanisms that underlie co-variation of the brain and face

(2011) Ralph S. Marcucio et al.   GENESIS

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

HP1 Recruits Activity-Dependent Neuroprotective Protein to H3K9me3 Marked Pericentromeric Heterochromatin for Silencing of Major Satellite Repeats

(2011) Kerstin Mosch et al.   PLoS One

Development of Social Vocalizations in Mice

(2011) Jasmine M. S. Grimsley et al.   PLoS One

Age-Related Impairment of Ultrasonic Vocalization in Tau.P301L Mice: Possible Implication for Progressive Language Disorders

(2011) Clément Menuet et al.   PLoS One

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects

(2009) Jie Shen et al.   EXPERIMENTAL GERONTOLOGY

Nitric Oxide Regulates Activity-Dependent Neuroprotective Protein (ADNP) in the Dentate Gyrus of the Rodent Model of Kainic Acid-Induced Seizure

(2009) Anna S. Cosgrave et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model

(2009) Natalia Shiryaev et al.   NEUROBIOLOGY OF DISEASE

Expression of Activity-Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis

(2009) Manjit Braitch et al.   NEUROIMMUNOMODULATION

The long-lasting effects of cross-fostering on the emotional behavior in ICR mice

(2008) Lingling Lu et al.   BEHAVIOURAL BRAIN RESEARCH

A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease

(2008) Y. Matsuoka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells

(2008) E. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete Sequence of a Novel Protein Containing a Femtomolar-Activity-Dependent Neuroprotective Peptide

(2003) Merav Bassan et al.   JOURNAL OF NEUROCHEMISTRY