Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome

A heterozygous microdeletion of 20q13.13 encompassing ADNP gene in a child with Helsmoortel–van der Aa syndrome

(2018) Minh-Tuan Huynh et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF)

(2018) Somi Kim et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes

(2018) Veronika Ostapcuk et al.   NATURE

Neurexin controls plasticity of a mature, sexually dimorphic neuron

(2018) Michael P. Hart et al.   NATURE

ADNP/NAP dramatically increase microtubule end-binding protein–Tau interaction: a novel avenue for protection against tauopathy

(2017) Y Ivashko-Pachima et al.   MOLECULAR PSYCHIATRY

Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children

(2017) I Gozes et al.   Translational Psychiatry

The role of the drebrin/EB3/Cdk5 pathway in dendritic spine plasticity, implications for Alzheimer’s disease

(2016) Phillip R. Gordon-Weeks   BRAIN RESEARCH BULLETIN

H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus

(2016) S. Snigdha et al.   JOURNAL OF NEUROSCIENCE

Automated quantitative analysis to assess motor function in different rat models of impaired coordination and ataxia

(2016) Elisavet I. Kyriakou et al.   JOURNAL OF NEUROSCIENCE METHODS

Sexual divergence in activity-dependent neuroprotective protein impacting autism, schizophrenia, and Alzheimer's disease

(2016) Illana Gozes   JOURNAL OF NEUROSCIENCE RESEARCH

Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory

(2016) N Amram et al.   MOLECULAR PSYCHIATRY

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Development of immune organs and functioning in humans and test animals: Implications for immune intervention studies

(2016) C. Frieke Kuper et al.   REPRODUCTIVE TOXICOLOGY

A systematic variant annotation approach for ranking genes associated with autism spectrum disorders

(2016) Eric Larsen et al.   Molecular Autism

Dendritic Polyglycerol Sulfate Inhibits Microglial Activation and Reduces Hippocampal CA1 Dendritic Spine Morphology Deficits

(2015) Dusica Maysinger et al.   BIOMACROMOLECULES

The Compassionate Side of Neuroscience: Tony Sermone’s Undiagnosed Genetic Journey—ADNP Mutation

(2015) Illana Gozes et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology

(2015) Philip Chang et al.   Journal of Neuroinflammation

ADNP: A major autism mutated gene is differentially distributed (age and gender) in the songbird brain

(2015) Gal Hacohen-Kleiman et al.   PEPTIDES

Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor

(2015) Martine N. Manuel et al.   Frontiers in Cellular Neuroscience

Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer’s pathologies

(2015) A Malishkevich et al.   Translational Psychiatry

Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines

(2015) Rasha Refaat Mahmmoud et al.   PLoS One

The transcriptional regulatorADNPlinks the BAF (SWI/SNF) complexes with autism

(2014) Geert Vandeweyer et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins

(2014) S Oz et al.   MOLECULAR PSYCHIATRY

A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP

(2014) Céline Helsmoortel et al.   NATURE GENETICS

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

Novel Marker for the Onset of Frontotemporal Dementia: Early Increase in Activity-Dependent Neuroprotective Protein (ADNP) in the Face of Tau Mutation

(2014) Yulie Schirer et al.   PLoS One

Heterozygous Ambra1 Deficiency in Mice: A Genetic Trait with Autism-Like Behavior Restricted to the Female Gender

(2014) Ekrem Dere et al.   Frontiers in Behavioral Neuroscience

A Double-Blind, Placebo-Controlled, Ascending-Dose, Randomized Study to Evaluate the Safety, Tolerability and Effects on Cognition of AL-108 after 12 Weeks of Intranasal Administration in Subjects with Mild Cognitive Impairment

(2013) Bruce H. Morimoto et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Pax6-Dependent Cortical Glutamatergic Neuronal Differentiation Regulates Autism-Like Behavior in Prenatally Valproic Acid-Exposed Rat Offspring

(2013) Ki Chan Kim et al.   MOLECULAR NEUROBIOLOGY

Autophagy has a key role in the pathophysiology of schizophrenia

(2013) A Merenlender-Wagner et al.   MOLECULAR PSYCHIATRY

NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: Protection against impairments in axonal transport

(2013) Yan Jouroukhin et al.   NEUROBIOLOGY OF DISEASE

Effects of Davunetide on N-acetylaspartate and Choline in Dorsolateral Prefrontal Cortex in Patients with Schizophrenia

(2013) L Fredrik Jarskog et al.   NEUROPSYCHOPHARMACOLOGY

Davunetide: a review of safety and efficacy data with a focus on neurodegenerative diseases

(2013) Bruce H Morimoto et al.   Expert Review of Clinical Pharmacology

Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus

(2012) David Verbich et al.   GLIA

Novel Evolutionary-conserved Role for the Activity-dependent Neuroprotective Protein (ADNP) Family That Is Important for Erythropoiesis

(2012) Efrat Dresner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Early motor and electrophysiological changes in transgenic mouse model of amyotrophic lateral sclerosis and gender differences on clinical outcome

(2011) Chrystian Junqueira Alves et al.   BRAIN RESEARCH

Activity-Dependent Neuroprotective Protein Modulates Its Own Gene Expression

(2011) Moutasem S. Aboonq et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Mosaic Activating Mutation inAKT1Associated with the Proteus Syndrome

(2011) Marjorie J. Lindhurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

HP1 Recruits Activity-Dependent Neuroprotective Protein to H3K9me3 Marked Pericentromeric Heterochromatin for Silencing of Major Satellite Repeats

(2011) Kerstin Mosch et al.   PLoS One

Effects of Ethanol and NAP on Cerebellar Expression of the Neural Cell Adhesion Molecule L1

(2011) Devon M. Fitzgerald et al.   PLoS One

Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia

(2011) Daniel C. Javitt et al.   SCHIZOPHRENIA RESEARCH

Evaluation of Pax6 Mutant Rat as a Model for Autism

(2010) Toshiko Umeda et al.   PLoS One

The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy

(2009) Ilona Zemlyak et al.   JOURNAL OF NEUROCHEMISTRY

Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling

(2009) R. Anne McKinney   JOURNAL OF PHYSIOLOGY-LONDON

Expression of Activity-Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis

(2009) Manjit Braitch et al.   NEUROIMMUNOMODULATION

Dendritic Spine Morphology Determines Membrane-Associated Protein Exchange between Dendritic Shafts and Spine Heads

(2008) Sylvain Hugel et al.   CEREBRAL CORTEX

ADNP Differential Nucleus/Cytoplasm Localization in Neurons Suggests Multiple Roles in Neuronal Differentiation and Maintenance

(2008) Shmuel Mandel et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Complete Sequence of a Novel Protein Containing a Femtomolar-Activity-Dependent Neuroprotective Peptide

(2003) Merav Bassan et al.   JOURNAL OF NEUROCHEMISTRY