Myopia Genetics and Heredity

Association of polymorphisms in ZFHX1B, KCNQ5 and GJD2 with myopia progression and polygenic risk prediction in children

(2021) Li Jia Chen et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Evaluation of Shared Genetic Susceptibility to High and Low Myopia and Hyperopia

(2021) J. Willem L. Tideman et al.   JAMA Ophthalmology

Risk Stratification and Clinical Utility of Polygenic Risk Scores in Ophthalmology

(2021) Ayub Qassim et al.   Translational Vision Science & Technology

New Polygenic Risk Score to Predict High Myopia in Singapore Chinese Children

(2021) Carla Lanca et al.   Translational Vision Science & Technology

Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish

(2021) Wim H. Quint et al.   Communications Biology

Increased Time Outdoors Is Followed by Reversal of The Long-term Trend to Reduced Visual Acuity in Taiwan Primary School Students

(2020) Pei-Chang Wu et al.   OPHTHALMOLOGY

Independent Influence of Parental Myopia on Childhood Myopia in a Dose-related Manner in 2055 Trios: The Hong Kong Children Eye Study

(2020) Shu Min Tang et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Non-additive (dominance) effects of genetic variants associated with refractive error and myopia

(2020) Alfred Pozarickij et al.   MOLECULAR GENETICS AND GENOMICS

Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

(2020) Pirro G. Hysi et al.   NATURE GENETICS

Mutation screening of 17 candidate genes in a cohort of 67 probands with early‐onset high myopia

(2020) Fang Liu et al.   OPHTHALMIC AND PHYSIOLOGICAL OPTICS

Genome-wide association study in Asians identifies novel loci for high myopia and highlights a nervous system role in its pathogenesis

(2020) Akira Meguro et al.   OPHTHALMOLOGY

Association of Parental Myopia With Higher Risk of Myopia Among Multiethnic Children Before School Age

(2020) Xuejuan Jiang et al.   JAMA Ophthalmology

Osteogenesis imperfecta: Novel genetic variants and clinical observations from a clinical exome study of 54 Indian patients

(2020) Vrisha Madhuri et al.   ANNALS OF HUMAN GENETICS

Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

(2019) Adriana I. Iglesias et al.   Nature Communications

Prevalence, Characteristics, and Risk Factors of Moderate/High Hyperopia among Multiethnic Children 6 to 72 Months Old – A Pooled Analysis of Individual Participant Data

(2019) Xuejuan Jiang et al.   OPHTHALMOLOGY

CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection

(2019) Jiamin Ouyang et al.   HUMAN MOLECULAR GENETICS

Association Between Type of Educational System and Prevalence and Severity of Myopia Among Male Adolescents in Israel

(2019) Dana Bez et al.   JAMA Ophthalmology

Association of the ZC3H11B, ZFHX1B and SNTB1 genes with myopia of different severities

(2019) Shu Min Tang et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

ncRNA-eQTL: a database to systematically evaluate the effects of SNPs on non-coding RNA expression across cancer types

(2019) Jiang Li et al.   NUCLEIC ACIDS RESEARCH

Association Between Polygenic Risk Score and Risk of Myopia

(2019) Neema Ghorbani Mojarrad et al.   JAMA Ophthalmology

Two-Year Clinical Trial of the Low-Concentration Atropine for Myopia Progression (LAMP) Study

(2019) Jason C. Yam et al.   OPHTHALMOLOGY

Association of thePAX6gene with extreme myopia rather than lower grade myopias

(2018) Shu Min Tang et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Vitamin D and its pathway genes in myopia: systematic review and meta-analysis

(2018) Shu Min Tang et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Autosomal-dominant myopia associated to a novel P4HA2 missense variant and defective collagen hydroxylation

(2018) F. Napolitano et al.   CLINICAL GENETICS

Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

(2018) Milly S. Tedja et al.   NATURE GENETICS

Low-Concentration Atropine for Myopia Progression (LAMP) Study

(2018) Jason C. Yam et al.   OPHTHALMOLOGY

The epidemics of myopia: Aetiology and prevention

(2018) Ian G. Morgan et al.   PROGRESS IN RETINAL AND EYE RESEARCH

CCDC102B confers risk of low vision and blindness in high myopia

(2018) Yoshikatsu Hosoda et al.   Nature Communications

Environmental Risk Factors Can Reduce Axial Length Elongation and Myopia Incidence in 6- to 9-Year-Old Children

(2018) J. Willem L. Tideman et al.   OPHTHALMOLOGY

Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci

(2018) Rupal L. Shah et al.   HUMAN GENETICS

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort

(2018) X Raymond Gao et al.   HUMAN MOLECULAR GENETICS

GENCODE reference annotation for the human and mouse genomes

(2018) Adam Frankish et al.   NUCLEIC ACIDS RESEARCH

Prediction of myopia development among Chinese school-aged children using refraction data from electronic medical records: A retrospective, multicentre machine learning study

(2018) Haotian Lin et al.   PLOS MEDICINE

Trio-based exome sequencing arrests de novo mutations in early-onset high myopia

(2017) Zi-Bing Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rasgrf1 mRNA expression in myopic eyes of guinea pigs

(2016) Qianwen Gong et al.   Clinical and Experimental Optometry

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050

(2016) Brien A. Holden et al.   OPHTHALMOLOGY

What Public Policies Should Be Developed to Deal with the Epidemic of Myopia?

(2016) Ian G. Morgan   OPTOMETRY AND VISION SCIENCE

Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error

(2016) Qiao Fan et al.   Nature Communications

Prevalence of refractive error in Europe: the European Eye Epidemiology (E3) Consortium

(2015) Katie M. Williams et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Assessing the Genetic Predisposition of Education on Myopia: A Mendelian Randomization Study

(2015) Gabriel Cuellar-Partida et al.   GENETIC EPIDEMIOLOGY

Mutations of P4HA2 encoding prolyl 4-hydroxylase 2 are associated with nonsyndromic high myopia

(2015) Hui Guo et al.   GENETICS IN MEDICINE

Effect of Time Spent Outdoors at School on the Development of Myopia Among Children in China

(2015) Mingguang He et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The myopia boom

(2015) Elie Dolgin   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Visual Consequences of Refractive Errors in the General Population

(2015) Virginie J.M. Verhoeven et al.   OPHTHALMOLOGY

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

(2015) Masahiro Miyake et al.   Nature Communications

APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans

(2015) Andrei V. Tkatchenko et al.   PLoS Genetics

Detection of Mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 Families With Early-Onset High Myopia by Exome Sequencing

(2014) D. Jiang et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

SLC39A5mutations interfering with the BMP/TGF-β pathway in non-syndromic high myopia

(2014) Hui Guo et al.   JOURNAL OF MEDICAL GENETICS

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders

(2014) Joanna S. Amberger et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Meta-Analysis of Myopia and Hyperopia Provides Evidence for Replication of 11 Loci

(2014) Claire L. Simpson et al.   PLoS One

Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error

(2013) Ching-Yu Cheng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in LRPAP1 Are Associated with Severe Myopia in Humans

(2013) Mohammed A. Aldahmesh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in SCO2 Are Associated with Autosomal-Dominant High-Grade Myopia

(2013) Khanh-Nhat Tran-Viet et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Myopia-Related Fundus Changes in Singapore Adults With High Myopia

(2013) Lan Chang et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Education influences the role of genetics in myopia

(2013) Virginie J. M. Verhoeven et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Exome sequencing reveals CCDC111 mutation associated with high myopia

(2013) Fuxin Zhao et al.   HUMAN GENETICS

Education influences the association between genetic variants and refractive error: a meta-analysis of five Singapore studies

(2013) Qiao Fan et al.   HUMAN MOLECULAR GENETICS

Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error

(2013) Dwight Stambolian et al.   HUMAN MOLECULAR GENETICS

A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population

(2013) Y. Shi et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia

(2013) Chiea Chuen Khor et al.   HUMAN MOLECULAR GENETICS

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

(2013) Virginie J M Verhoeven et al.   NATURE GENETICS

Patterns of myopigenic activities with age, gender and ethnicity in Sydney schoolchildren

(2013) Amanda N French et al.   OPHTHALMIC AND PHYSIOLOGICAL OPTICS

Risk Factors for Incident Myopia in Australian Schoolchildren

(2013) Amanda N. French et al.   OPHTHALMOLOGY

Association of IGF1 Gene Haplotypes With High Myopia in Chinese Adults

(2012) Joey Y. Y. Mak   ARCHIVES OF OPHTHALMOLOGY

Myopia

(2012) Ian G Morgan et al.   LANCET

The Association between Time Spent Outdoors and Myopia in Children and Adolescents

(2012) Justin C. Sherwin et al.   OPHTHALMOLOGY

The complex interactions of retinal, optical and environmental factors in myopia aetiology

(2012) D.I. Flitcroft   PROGRESS IN RETINAL AND EYE RESEARCH

Genetic Variants on Chromosome 1q41 Influence Ocular Axial Length and High Myopia

(2012) Qiao Fan et al.   PLoS Genetics

Genetic Variants at 13q12.12 Are Associated with High Myopia in the Han Chinese Population

(2011) Yi Shi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Retinal and Choroidal Thickness in Early Age-Related Macular Degeneration

(2011) Ashley Wood et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

A genome-wide association study reveals association between common variants in an intergenic region of 4q25 and high-grade myopia in the Chinese Han population

(2011) Zhiqiang Li et al.   HUMAN MOLECULAR GENETICS

Atropine for the Treatment of Childhood Myopia: Safety and Efficacy of 0.5%, 0.1%, and 0.01% Doses (Atropine for the Treatment of Myopia 2)

(2011) Audrey Chia et al.   OPHTHALMOLOGY

Exome Sequencing Identifies ZNF644 Mutations in High Myopia

(2011) Yi Shi et al.   PLoS Genetics

Features Associated With Foveal Retinal Detachment in Myopic Macular Retinoschisis

(2010) Masahiro Fujimoto et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Nonsyndromic High Myopia in a Chinese Family Mapped to MYP1

(2010) Xiangming Guo   ARCHIVES OF OPHTHALMOLOGY

X-linked myopia: Bornholm Eye Disease

(2010) Marianne Schwartz et al.   CLINICAL GENETICS

A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25

(2010) Pirro G Hysi et al.   NATURE GENETICS

A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14

(2010) Abbas M Solouki et al.   NATURE GENETICS

Genome-Wide Association Studies Reveal Genetic Variants in CTNND2 for High Myopia in Singapore Chinese

(2010) Yi-Ju Li et al.   OPHTHALMOLOGY

Myopia Over the Lifecourse: Prevalence and Early Life Influences in the 1958 British Birth Cohort

(2010) Jugnoo S. Rahi et al.   OPHTHALMOLOGY

TGFB1 as a Susceptibility Gene for High Myopia

(2009) Yi Zha   ARCHIVES OF OPHTHALMOLOGY

Increased Prevalence of Myopia in the United States Between 1971-1972 and 1999-2004

(2009) Susan Vitale   ARCHIVES OF OPHTHALMOLOGY

Heritability Analysis of Spherical Equivalent, Axial Length, Corneal Curvature, and Anterior Chamber Depth in the Beaver Dam Eye Study

(2009) Alison P. Klein   ARCHIVES OF OPHTHALMOLOGY

The Association of Haplotype at the Lumican Gene with High Myopia Susceptibility in Taiwanese Patients

(2009) Zoe Tzu-Yi Chen et al.   OPHTHALMOLOGY

A Genome-Wide Association Analysis Identified a Novel Susceptible Locus for Pathological Myopia at 11q24.1

(2009) Hideo Nakanishi et al.   PLoS Genetics

Outdoor Activity Reduces the Prevalence of Myopia in Children

(2008) Kathryn A. Rose et al.   OPHTHALMOLOGY