Article
Ophthalmology
Li Jia Chen, Fen Fen Li, Shi Yao Lu, Xiu Juan Zhang, Ka Wai Kam, Shu Min Tang, Pancy Os Tam, Wilson Wk Yip, Alvin L. Young, Clement C. Tham, Chi Pui Pang, Jason C. Yam
Summary: This study found that SNPs in ZFHX1B, KCNQ5, and GJD2 are associated with myopia progression in children. Children with a high-risk PRS defined by GJD2 rs524952, KCNQ5 rs7744813, and ZFHX1B rs13382811 had a 2.26-fold increased risk of fast myopia progression.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Junbin Liu, Riping Zhang, Lixia Sun, Yuqian Zheng, Shaowan Chen, Shao-Lang Chen, Yanxuan Xu, Chi-Pui Pang, Mingzhi Zhang, Tsz Kin Ng
Summary: The study identified significant associations of 4q25, 15q14, and MIPEP variants with myopia and different severity of myopia in the southern Chinese population, jointly enhancing a 10-fold risk predisposition to high myopia. The correlation of these variants with axial length and corneal parameters suggests their impact on the refractive status of high myopia subjects.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Razek G. Coussa, Elaine M. Binkley, Mark E. Wilkinson, Jeaneen L. Andorf, Budd A. Tucker, Robert F. Mullins, Elliott H. Sohn, Lawrence A. Yannuzzi, Edwin M. Stone, Ian C. Han
Summary: Patients with AD-BVMD are predominantly hyperopic, whereas those with Stargardt disease are predominantly myopic. The findings provide further evidence of a role for BEST1 in ocular growth and development.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Fen Fen Li, Shi Yao Lu, Shu Min Tang, Ka Wai Kam, Tam O. S. Pancy, Wilson W. K. Yip, Alvin L. Young, Clement C. Tham, Chi Pui Pang, Jason C. Yam, Li Jia Chen
Summary: The study revealed ZC3H11B and BICC1 as genetic risk factors for moderate and high myopia, while ZC3H11B, KCNQ5, SNTB1 and GJD2 are associated with excessive axial length in children.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Zhong Lin, Balamurali Vasudevan, Tieying Gao, Hongjia Zhou, Kenneth J. Ciuffreda, Yuanbo Liang
Summary: This study found relatively low myopic refractive change and myopia incidence among Chinese rural children aged 6-17 years. Children's refraction and paternal refraction were associated with both myopic refractive change and myopia incidence, providing helpful information for further comparisons in other rural versus urban areas of China and other countries.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Klaus Trier, Dongmei Cui, Soren Ribel-Madsen, Jeremy Guggenheim
Summary: Oral intake of 7-methylxanthine (7-MX) was found to reduce myopia progression and axial elongation in myopic children from Denmark, without any reported adverse effects.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yuanyuan Zhong, Meng Li, Tian Han, Dan Fu, Xingtao Zhou
Summary: This study shows that SMILE is effective and safe for correcting high astigmatism. There is a tendency for undercorrection of astigmatism in subjects with high astigmatism based on vector analysis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jinjin Yu, Guoli Zhao, Chak Seng Lei, Ting Wan, Rui Ning, Wenqian Xing, Xindi Ma, Hongxian Pan, Giacomo Savini, Domenico Schiano-Lomoriello, Xingtao Zhou, Jinhai Huang
Summary: The study aimed to evaluate the repeatability and reproducibility of ocular measurements obtained using the Suoer SW-9000mu m Plus biometer based on optical low coherence reflectometry (OLCR), and compare them to measurements from a swept-source optical coherence tomography (SS-OCT) biometer. The results showed excellent repeatability and reproducibility of the new biometer, with parameters similar to those measured by the SS-OCT biometer.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jack A. Campbell, John G. Ladas, Kendrick Wang, Fasika Woreta, Divya Srikumaran
Summary: All formulas except the Haigis formula resulted in a hyperopic error. The corneal power modification significantly reduced error in four out of five IOL formulas.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Alexandre Ducloux, Simon Marillet, Pierre Ingrand, Mark A. Bullimore, Rupert R. A. Bourne, Nicolas Leveziel
Summary: This study evaluated the progression of myopia in teenagers and adults in France and found that the youngest age groups had the highest proportion of progressors. Young age and higher myopia at baseline were strongly associated with the risk of developing high myopia.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jit B. Ale Magar, Shaheen P. Shah, Shuan Dai
Summary: This study evaluated the ocular biometric changes in children with intermittent exotropia treated with and without overminus lens. The results showed that overminus therapy does not affect normal refractive growth in children, without considering other myopia risk factors.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ian Flitcroft, Sara Mccullough, Kathryn Saunders
Summary: In young children, small degrees of anisometropia (>= 0.5 D) are associated with impaired emmetropisation. This suggests that anisometropia is a marker for poorly regulated eye growth, indicating that, in addition to environmental and genetic influences on eye growth, stochastic processes contribute to refractive outcomes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jae Shin Song, Young Bok Lee, Ji-Ah Kim, Eun Ji Lee, Hyunjoong Kim
Summary: There is an association between corneal refractive surgery and the prevalence of glaucoma in the Korean population, but this association is not observed in eyes with high myopia.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Elizabeth Joseph, C. K. Meena, Rahul Kumar, Mary Sebastian, Catherine M. Suttle, Nathan Congdon, Sheeladevi Sethu, Gudlavalleti V. S. Murthy
Summary: This study aimed to estimate the prevalence, severity, and determinants of refractive errors among school-going children in India. The results showed that myopia, especially, is common in India, with a higher prevalence among older children and variations between different regions, genders, and school types.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Physics, Multidisciplinary
Zhaoyang Zhang, Yuan Feng, Feng Li, Sergei Koniakhin, Changbiao Li, Fu Liu, Yanpeng Zhang, Min Xiao, Guillaume Malpuech, Dmitry Solnyshkov
Summary: The Klein paradox refers to the perfect tunneling of relativistic particles through high potential barriers, which is responsible for the exceptional conductive properties of graphene. Recent studies have explored this phenomenon in atomic condensates, topological photonics, and phononics. In this study, the authors experimentally observed perfect Klein transmission in a 2D photonic system (photonic graphene) and measured its angular dependence. Interestingly, they found that increasing the barrier height suppresses the decay of Klein transmission with angle, in agreement with the Dirac equation.
PHYSICAL REVIEW LETTERS
(2022)
Article
Ophthalmology
Ankit Singh Tomar, Paul T. Finger, Brenda Gallie, Tero Kivela, Ashwin Mallipatna, Chengyue Zhang, Junyang Zhao, Matthew Wilson, Rachel Brennan, Michala Burges, Jonathan Kim, Jesse L. Berry, Rima Jubran, Vikas Khetan, Suganeswari Ganeshan, Andrey Yarovoy, Vera Yarovaya, Elena Kotova, Denis Volodin, Yacoub Yousef, Kalle Nummi, Tatiana L. Ushakova, Olga Yugay, Vladimir G. Polyakov, Marco Antonio Ramirez-Ortiz, Elizabeth Esparza-Aguiar, Guillermo L. Chantada, Paula Schaiquevich, Adriana C. Fandino, Jason C. Yam, Winnie W. Lau, Carol P. Lam, Phillipa Sharwood, Sonia Moorthy, Quah Boon Long, Vera Adobea Essuman, Lorna A. Renner, Ekaterina Semenova, Jaume Catala-Mora, Maria Correa Llano, Elisa Carreras
Summary: This study analyzed data from 1054 RB eyes from 18 ophthalmic oncology centers worldwide and found that eyes with diffuse intraocular distribution of RB seeds had a higher risk of local treatment failure compared to eyes with focal seeds. Therefore, further subclassification of AJCC RB category cT2b into focal and diffuse seeds can improve prognostication for eye salvage.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Shi Yao Lu, Xiu Juan Zhang, Yu Meng Wang, Nan Yuan, Ka Wai Kam, Poemen P. Chan, Pancy Os Tam, Wilson Wk Yip, Alvin L. Young, Clement C. Tham, Chi Pui Pang, Jason C. Yam, Li Jia Chen
Summary: This study investigated the association between SIX1-SIX6 gene variants and peripapillary retinal nerve fibre layer (p-RNFL) thickness in children, finding significant SNPs that were age and sex-dependent.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jason C. C. Yam, Xiu Juan Zhang, Ka Wai Kam, Li Jia Chen, Clement C. C. Tham, Chi Pui Pang
Summary: The incidence of myopia among schoolchildren in Hong Kong more than doubled during the COVID-19 pandemic, with decreased outdoor time and increased screen time. Low-concentration atropine is effective in reducing myopia progression with a concentration-related response. An age-dependent effect and choroidal thickening were observed with low-concentration atropine treatment.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Review
Public, Environmental & Occupational Health
Sylvia Agyekum, Poemen P. Chan, Yuzhou Zhang, Zhaohua Huo, Benjamin H. K. Yip, Patrick Ip, Clement C. Tham, Li Jia Chen, Xiu Juan Zhang, Chi Pui Pang, Jason C. Yam
Summary: The rising global prevalence of myopia poses a significant public health concern. This systematic review examines the cost-effectiveness of interventions for treating myopia. Six studies meeting the eligibility criteria were included, assessing costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICER). The findings suggest that photorefractive screening plus 0.01% atropine and corneal refractive surgery are cost-effective, while ranibizumab and conbercept show to be more cost-effective than photodynamic therapy for pathologic myopia. Prevention of myopia progression is more cost-effective than treating pathologic myopia.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Xiu Juan Zhang, Yuzhou Zhang, Ka Wai Kam, Fangyao Tang, Yi Li, Mandy P. H. Ng, Alvin L. Young, Patrick Ip, Clement C. Tham, Li Jia Chen, Chi Pui Pang, Jason C. Yam
Summary: During the COVID-19 pandemic, childhood myopia increased. This study examined the prevalence of myopia and its associated factors before, during, and after COVID-19 restrictions. The findings showed that after the restrictions were lifted, myopia prevalence among children in Hong Kong was higher than before the pandemic, and their lifestyle did not return to pre-COVID-19 levels. Younger children and those from low-income families were at a higher risk of myopia development during the pandemic.
Review
Ophthalmology
Xiu Juan Zhang, Xiu Nian Chen, Fang Yao Tang, Simon Szeto, Xiang Tian Ling, Zi Xuan Lin, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Jason C. Yam
Summary: By conducting a systematic review and meta-analysis of various studies, we have summarized the associated factors of myopic choroidal neovascularization (CNV). These factors include a higher risk of lacquer cracks and patchy chorioretinal atrophy, greater posterior staphyloma height, thinner choroidal thickness, and higher levels of vascular endothelial growth factor and interleukin-8 in the aqueous humor of eyes with myopic CNV.
SURVEY OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Youjuan Zhang, Xiu Juan Zhang, Nan Yuan, Yu Meng Wang, Patrick Ip, Li Jia Chen, Clement C. Tham, Chi Pui Pang, Jason C. Yam
Summary: This systematic review examines the association between secondhand smoke (SHS) exposure and ocular health. The study found compelling evidence linking SHS exposure to eye irritation, conjunctivitis, and dry eye symptoms, but limited and controversial evidence for other ocular disorders, structures, and parameters. Further high-quality and rigorous research is needed to elucidate the potentially harmful effects of SHS exposure on ocular health.
SURVEY OF OPHTHALMOLOGY
(2023)
Review
Genetics & Heredity
Yu Peng, Christine H. T. Bui, Xiu J. Zhang, Jian S. Chen, Clement C. Tham, Wai K. Chu, Li J. Chen, Chi P. Pang, Jason C. Yam
Summary: This review summarizes the role of EZH2 in different ocular diseases and the potential mechanisms. EZH2, acting as a catalytic subunit of PRC2 to catalyze lysine 27 in histone H3, induces the suppression of gene expression. EZH2 can regulate cell proliferation and differentiation of retinal progenitors, which are required for physiological retinal development. Meanwhile, an abnormal level of EZH2 has been observed in ocular tumors and other pathological tissues. We highlight the potential of targeting EZH2 as a precision therapeutic target in ocular diseases.
Article
Ophthalmology
Xiu Juan Zhang, Duncan Ka Shun Chau, Yu Meng Wang, Cynthia Sze Hang Cheung, Hei-Nga Chan, Jian Shi, Ka Ming Nip, Shumin Tang, Ryan C. F. Chan, Alistair Lau, Sit Hui Kei, Ka Wai Kam, Alvin L. Young, Li Jia Chen, Clement C. Tham, Kyoko Ohno-Matsui, Chi Pui Pang, Jason C. Yam
Summary: The study aimed to investigate the prevalence and characteristics of the peripapillary gamma zone in myopic, emmetropic, and hyperopic eyes of Chinese children. The results showed that the prevalence of the peripapillary gamma zone was higher in myopic eyes compared to emmetropic and hyperopic eyes, and the characteristics and distribution patterns were significantly different between different refractive groups.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Zhen Ji Chen, Danny S. C. Ng, Ling-Ping Cen, Tsz Kin Ng, Mary Ho, Marten E. Brelen, Tai-Ping Li, Shi Yao Lu, Pancy O. S. Tam, Alvin L. Young, Weiqi Chen, Jason C. Yam, Haoyu Chen, Clement C. Tham, Chi Pui Pang, Li Jia Chen
Summary: This study identified the association of CFH and TNFRSF10A SNPs with chronic central serous chorioretinopathy (cCSCR). It suggested CFH as a potential genetic factor underlying the male predilection of cCSCR.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Yu Yao Wang, Xiu Juan Zhang, Ka Wai Kam, Zhen Ji Chen, Yuzhou Zhang, Fang Yao Tang, Fen Fen Li, Pancy O. S. Tam, Wilson W. K. Yip, Alvin L. Young, Clement C. Tham, Chi Pui Pang, Jason C. Yam, Li Jia Chen
Summary: This study identified two susceptible gene variants, ZFHX1B rs13382811 and PAX6 rs644242, for anisometropia development in Hong Kong Chinese children, implicating their role in imbalanced refractive change and axial elongation between both eyes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Medicine, General & Internal
Joyce J. T. Chan, Emily S. Wong, Carol P. S. Lam, Jason C. Yam
Summary: There is no consensus on the optimal target refraction after intraocular lens implantation in infants. This study shows that younger age at operation is associated with larger myopic shifts and immediate postoperative refraction can predict spherical equivalent refraction at 1 year but not at 10 years. Moreover, high postoperative hyperopia (≥+7.00 D) is correlated with worse final visual acuity.
HONG KONG MEDICAL JOURNAL
(2023)
Review
Ophthalmology
Ka Wai Kam, Antonio Di Zazzo, Chiara De Gregorio, Purvasha Narang, Vishal Jhanji, Sayan Basu
Summary: Dry eye disease can be caused by medications that interfere with lacrimal and meibomian gland function, affect ocular surface homeostasis, or induce inflammation. This review focuses on specific drugs, such as systemic isotretinoin and taxanes, immune checkpoint inhibitors, gliptins and topical antiglaucoma medications, and epidermal growth factor receptor inhibitors, fibroblast growth factor receptor inhibitors, and belantamab mafodotin, that are known to cause dry eye disease or dryness symptoms. Awareness of these drug-induced causes and their potential side effects is important for ophthalmologists.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Meeting Abstract
Ophthalmology
Xiangtian Ling, Xiu Juan Zhang, Christine Bui, Clement C. Tham, Calvin C. P. Pang, Li Jia Chen, Jason C. Yam
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)