Article
Medicine, General & Internal
Carter J. Payne, Courtney R. Webster, Majid Moshirfar, Jaiden J. Handlon, Yasmyne C. Ronquillo, Phillip C. Hoopes
Summary: This study presents a retrospective report on the one-year visual outcomes of Small Incision Lenticule Extraction (SMILE) for myopia and myopic astigmatism. The results indicate that SMILE is a safe and effective treatment with positive clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Muktar Ahmed, Ville-Petteri Makinen, Anwar Mulugeta, Jisu Shin, Terry Boyle, Elina Hypponen, Sang Hong Lee
Summary: This study analyzes data from the UK Biobank, considering multiple hormone-sensitive cancers as a single disease, and identifies substantial SNP-based heritability. The study discovers 55 variants with genome-wide significance. The findings suggest that hormone-sensitive cancers may share common genetic risk factors.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sayuri Sekimitsu, Jiali Wang, Tobias Elze, Ayellet Segre, Janey L. Wiggs, Nazlee Zebardast
Summary: This study demonstrates the utility of a genome-wide polygenic risk score (PRS) in identifying individuals at higher risk of primary angle closure glaucoma (PACG). Additionally, it reveals an important relationship between psychotropic medication use and PACG diagnosis across the polygenic risk spectrum.
Article
Medicine, General & Internal
Changting Tang, Zijing Du, Guanrong Wu, Xuanyun Tan, Siwen Zang, Honghua Yu, Yijun Hu
Summary: This study investigated the distribution of ocular residual astigmatism (ORA) and its associations with age, gender, manifest refraction, and other ocular indicators in Chinese patients with myopia. The findings suggest that ORA is influenced by multiple ocular factors and can provide valuable information for astigmatism correction in candidates for refractive surgery.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xingxue Zhu, Yuliang Wang, Yujia Liu, Chaoying Ye, Xingtao Zhou, Xiaomei Qu
Summary: This study found that the use of 0.01% atropine eye drops can effectively prevent myopia progression, but it also leads to an increase in axial length and total astigmatism in myopic Chinese children.
Article
Cell Biology
Jessica Kain, Katherine A. Owen, Miranda C. Marion, Carl D. Langefeld, Amrie C. Grammer, Peter E. Lipsky
Summary: This study utilizes traditional Mendelian randomization methods to discover the causal relationship between SLE and CAD, and through clustering analysis and pathway analysis, demonstrates the potential biological pathways that may contribute to both diseases.
CELL REPORTS MEDICINE
(2022)
Article
Medicine, General & Internal
Ignacio Almorin-Fernandez-Vigo, Ines Sanchez-Guillen, Jose Ignacio Fernandez-Vigo, Barbara Burgos-Blasco, Lucia De-Pablo-Gomez-de-Liano, Jose angel Fernandez-Vigo, Ana Macarro-Merino
Summary: This study aims to obtain normative corneal astigmatism data in a local population and describe their axis distribution and association with other parameters. The results showed that the mean anterior corneal astigmatism (ACA) and posterior corneal astigmatism (PCA) were 1.01 ± 0.79 D and 0.34 ± 0.17 D, respectively. The vertical steep axis distribution accounted for 73.5% of ACA and 93.3% of PCA. The frequency of vertical ACA orientation decreased with age, while the frequency of vertical PCA orientation increased with higher PCA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Lei Clifton, Jennifer A. Collister, Xiaonan Liu, Thomas J. Littlejohns, David J. Hunter
Summary: This study aimed to evaluate the differences between different polygenic risk scores (PRS) in individual risk prediction. The study found large differences between different PRS for breast cancer, hypertension, and dementia, leading to significant variations in individual risk prediction. This could result in individuals receiving different medical advice depending on which PRS is used. Therefore, it is important to address these differences before using PRS for risk stratification.
SCIENTIFIC REPORTS
(2022)
Article
Respiratory System
Boyang Li, Yuxuan Wang, Zixiao Wang, Xinyue Li, Shannon Kay, Geoffrey L. Chupp, Hongyu Zhao, Jose L. Gomez
Summary: This study aimed to characterize the genetic architecture of blood eosinophil counts and asthma in the UK Biobank. The research found a genetic correlation between asthma and blood eosinophil counts, with the STAT6 signaling pathway being a key shared pathway between the two traits. These findings define the shared genetic architecture between blood eosinophil counts and asthma risk in individuals of European ancestry.
Article
Medicine, General & Internal
Changfei Li, Li Zeng, Jiaqi Zhou, Bingjie Wang, Zhi Chen
Summary: This retrospective study investigated the relationship between the toricity of dual-axis corneal refractive therapy (CRT) orthokeratology lenses and corneal parameters. The study found a positive correlation between corneal astigmatism and the difference in elevation at 8 mm chord length with CRT lens toricity. The difference in elevation at 8 mm chord length can be used to estimate CRT lens toricity in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Antonia V. Seligowski, Burook Misganaw, Lucie A. Duffy, Kerry J. Ressler, Guia Guffanti
Summary: This study used a large biobank sample to investigate the shared genetic risk between PTSD and CVD. The results suggest that PTSD may be a risk factor for hypertension and coronary artery disease. Further research is needed to determine the clinical implications of these findings.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Naaheed Mukadam, Olga Giannakopoulou, Nick Bass, Karoline Kuchenbaecker, Andrew McQuillin
Summary: This study explored the association between genetic risk scores (GRS) and dementia risk among different ethnic groups. The study found that the z-standardized GRS, including APOE, was associated with an increased risk of dementia, and excluding APOE from the GRS also increased dementia risk. Additionally, the predictive effect of GRS on secondary outcomes was less robust in non-European ancestry groups.
Article
Green & Sustainable Science & Technology
Wenfei Zhu, Longhai Zhang, Ling Zhang, Longkun Qiu, Jiawei Guo, Zheng'ao Li, Yuliang Sun
Summary: Research shows a negative association between physical activity and refractive error, especially outdoor activity. This study examines the association of physical activity levels and sedentary time with refractive error in boys and girls living in urban and rural areas. The results suggest that maintaining a healthy lifestyle can help reduce the risk of refractive error in boys and girls.
Article
Genetics & Heredity
Edita Kunceviciene, Tomas Muskieta, Margarita Sriubiene, Rasa Liutkeviciene, Alina Smalinskiene, Ingrida Grabauskyte, Ruta Insodaite, Dovile Juoceviciute, Laimutis Kucinskas
Summary: This study evaluated the associations of GJD2 and RASGRF1 gene polymorphisms with refractive errors. The study found that GJD2 rs634990 was significantly associated with the co-occurrence of hyperopia and astigmatism.
Article
Medicine, General & Internal
Abdulrahman A. Almazrou, Wala A. Abualnaja, Amani A. Abualnaja, Ahmed Z. Alkhars
Summary: This study aimed to investigate the relationship between central corneal thickness (CCT) and age, gender, refractive errors, and corneal curvature in a Saudi population. The results showed a significant difference in the mean CCT across different refractive errors. There was no significant association between mean corneal curvature and CCT in the Saudi population. However, a significant association was observed between spherical equivalent in myopic patients and CCT.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Ophthalmology
Denis Plotnikov, Cathy Williams, Jeremy A. Guggenheim
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Tim T. Morris, Jeremy A. Guggenheim, Kate Northstone, Cathy Williams
OPHTHALMIC EPIDEMIOLOGY
(2020)
Article
Ophthalmology
Neema Ghorbani Mojarrad, Denis Plotnikov, Cathy Williams, Jeremy A. Guggenheim, Tariq Aslam, Sarah A. Barman, Jenny H. Barrett, Paul Bishop, Peter Blows, Catey Bunce, Roxana O. Carare, Usha Chakravarthy, Michelle Chan, Sharon Y. L. Chua, David P. Crabb, Philippa M. Cumberland, Alexander Day, Parul Desai, Bal Dhillon, Andrew D. Dick, Cathy Egan, Sarah Ennis, Paul Foster, Marcus Fruttiger, John E. J. Gallacher, David F. Garway-Heath, Jane Gibson, Dan Gore, Jeremy A. Guggenheim, Chris J. Hammond, Alison Hardcastle, Simon P. Harding, Ruth E. Hogg, Pirro Hysi, Pearse A. Keane, Sir Peng T. Khaw, Anthony P. Khawaja, Gerassimos Lascaratos, Andrew J. Lotery, Tom Macgillivray, Sarah Mackie, Keith Martin, Michelle McGaughey, Bernadette McGuinness, Gareth J. Mckay, Martin McKibbin, Danny Mitry, Tony Moore, James E. Morgan, Zaynah A. Muthy, Eoin O'Sullivan, Chris G. Owen, Praveen Patel, Euan Paterson, Tunde Peto, Axel Petzold, Jugnoo S. Rahi, Alicja R. Rudnikca, Jay Self, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas Strouthidis, Cathie Sudlow, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Veronique Vitart, Stephen A. Vernon, Ananth C. Viswanathan, Cathy Williams, Katie Williams, Jayne V. Woodside, Max M. Yates, Jennifer Yip, Yalin Zheng
JAMA OPHTHALMOLOGY
(2020)
Article
Genetics & Heredity
Despoina Manousaki, Ruth Mitchell, Tom Dudding, Simon Haworth, Adil Harroud, Vincenzo Forgetta, Rupal L. Shah, Jian'an Luan, Claudia Langenberg, Nicholas J. Timpson, J. Brent Richards
AMERICAN JOURNAL OF HUMAN GENETICS
(2020)
Article
Biochemistry & Molecular Biology
Alfred Pozarickij, Cathy Williams, Jeremy A. Guggenheim
MOLECULAR GENETICS AND GENOMICS
(2020)
Article
Genetics & Heredity
Pirro G. Hysi, Helene Choquet, Anthony P. Khawaja, Robert Wojciechowski, Milly S. Tedja, Jie Yin, Mark J. Simcoe, Karina Patasova, Omar A. Mahroo, Khanh K. Thai, Phillippa M. Cumberland, Ronald B. Melles, Virginie J. M. Verhoeven, Veronique Vitart, Ayellet Segre, Richard A. Stone, Nick Wareham, Alex W. Hewitt, David A. Mackey, Caroline C. W. Klaver, Stuart MacGregor, Peng T. Khaw, Paul J. Foster, Jeremy A. Guggenheim, Jugnoo S. Rahi, Eric Jorgenson, Christopher J. Hammond
Article
Medicine, General & Internal
Ju-Sheng Zheng, Jian'an Luan, Eleni Sofianopoulou, Stephen J. Sharp, Felix R. Day, Fumiaki Imamura, Thomas E. Gundersen, Luca A. Lotta, Ivonne Sluijs, Isobel D. Stewart, Rupal L. Shah, Yvonne T. van der Schouw, Eleanor Wheeler, Eva Ardanaz, Heiner Boeing, Miren Dorronsoro, Christina C. Dahm, Niki Dimou, Douae El-Fatouhi, Paul W. Franks, Guy Fagherazzi, Sara Grioni, Jose Maria Huerta, Alicia K. Heath, Louise Hansen, Mazda Jenab, Paula Jakszyn, Rudolf Kaaks, Tilman Kuehn, Kay-Tee Khaw, Nasser Laouali, Giovanna Masala, Peter M. Nilsson, Kim Overvad, Anja Olsen, Salvatore Panico, J. Ramon Quiros, Olov Rolandsson, Miguel Rodriguez-Barranco, Carlotta Sacerdote, Annemieke M. W. Spijkerman, Tammy Y. N. Tong, Rosario Tumino, Konstantinos K. Tsilidis, John Danesh, Elio Riboli, Adam S. Butterworth, Claudia Langenberg, Nita G. Forouhi, Nicholas J. Wareham
Article
Biochemistry & Molecular Biology
Jeremy A. Guggenheim, Rosie Clark, Jiangtian Cui, Louise Terry, Karina Patasova, Annechien E. G. Haarman, Anthony M. Musolf, Virginie J. M. Verhoeven, Caroline C. W. Klaver, Joan E. Bailey-Wilson, Pirro G. Hysi, Cathy Williams
Summary: Refractive errors are associated with various pathological conditions and have a genetic component. This study identified novel candidate genes associated with refractive error and specific variants associated with refractive error type and age of spectacle wear. However, the study also highlighted the limitations of community-based WES studies compared to high myopia case-control WES studies.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Jeremy A. Guggenheim, Rosie Clark, Tetyana Zayats, Cathy Williams
Summary: This study analyzed 1944 pairs of adult siblings from the United Kingdom and found that the genetic risk for refractive error is primarily transmitted from parents to offspring, rather than through the environment created by parents.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Ophthalmology
Klaus Trier, Dongmei Cui, Soren Ribel-Madsen, Jeremy Guggenheim
Summary: Oral intake of 7-methylxanthine (7-MX) was found to reduce myopia progression and axial elongation in myopic children from Denmark, without any reported adverse effects.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Genetics & Heredity
Rosie Clark, Alfred Pozarickij, Pirro G. Hysi, Kyoko Ohno-Matsui, Cathy Williams, Jeremy A. Guggenheim
Summary: The study identifies genetic variants that interact with education level to increase susceptibility to myopia.
Editorial Material
Ophthalmology
Jeremy A. Guggenheim, Jeffrey J. Walline
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Medicine, General & Internal
Rosie Clark, Samantha Sze-Yee Lee, Ran Du, Yining Wang, Sander C. M. Kneepkens, Jason Charng, Yu Huang, Michael L. Hunter, Chen Jiang, J. Willem L. Tideman, Ronald B. Melles, Caroline C. W. Klaver, David A. Mackey, Cathy Williams, Helene Choquet, Kyoko Ohno-Matsui, Jeremy A. Guggenheim
Summary: This study aimed to predict the risk of high myopia (HM) through an improved polygenic score (PGS) and test if the PGS is predictive of myopic macular degeneration (MMD) after considering refractive error. The study found that PGS can predict the risk of HM in Europeans, but its predictive ability is weaker in other populations.
Article
Medicine, General & Internal
Nicholas Bowker, Rupal L. Shah, Stephen J. Sharp, Jian'an Luan, Isobel D. Stewart, Eleanor Wheeler, Manuel A. R. Ferreira, Aris Baras, Nicholas J. Wareham, Claudia Langenberg, Luca A. Lotta
Article
Ophthalmology
Alfred Pozarickij, Clair A. Enthoven, Neema Ghorbani Mojarrad, Denis Plotnikov, Milly S. Tedja, Annechien E. G. Haarman, J. Willem L. Tideman, Jan Roelof Polling, Kate Northstone, Cathy Williams, Caroline C. W. Klaver, Jeremy A. Guggenheim
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)