Exploration of Potential Ewing Sarcoma Drugs from FDA-Approved Pharmaceuticals through Computational Drug Repositioning, Pharmacogenomics, Molecular Docking, and MD Simulation Studies

Mechanistic insights into TNFR1/MADD death domains in Alzheimer’s disease through conformational molecular dynamic analysis

(2021) Mubashir Hassan et al.   Scientific Reports

A Review of Current In Silico Methods for Repositioning Drugs and Chemical Compounds

(2021) Binsheng He et al.   Frontiers in Oncology

A review of computational drug repositioning: strategies, approaches, opportunities, challenges, and directions

(2020) Tamer N. Jarada et al.   Journal of Cheminformatics

Epithelial-to-mesenchymal transition status of primary breast carcinomas and its correlation with metastatic behavior

(2019) C. D. Savci-Heijink et al.   BREAST CANCER RESEARCH AND TREATMENT

Association of VDR and OPG gene polymorphism with osteoporosis risk in Chinese postmenopausal women

(2019) F. Wu et al.   CLIMACTERIC

Endothelin-1 Activates the Notch Signaling Pathway and Promotes Tumorigenesis in Giant Cell Tumor of the Spine

(2019) Wei Yuan et al.   SPINE

GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner

(2019) Shu-Heng Jiang et al.   GUT

Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro

(2019) Marcus A. Weinman et al.   BMC CANCER

Role of Sodium Taurocholate Cotransporting Polypeptide as a New Reporter and Drug-Screening Platform: Implications for Preventing Hepatitis B Virus Infections

(2019) Menq-Rong Wu et al.   MOLECULAR IMAGING AND BIOLOGY

Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling

(2019) Tongzhou Hu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ABCG1 and Pgp identify drug resistant, self-renewing osteosarcoma cells

(2019) Elizabeth Ann Roundhill et al.   CANCER LETTERS

Transcription factor CEBPB inhibits the proliferation of osteosarcoma by regulating downstream target gene CLEC5A

(2019) Jianhua Lu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common β-Chain Cytokines IL-5 and GM-CSF

(2019) Ryan K. Nelson et al.   JOURNAL OF IMMUNOLOGY

Identification of critical genes associated with human osteosarcoma metastasis based on integrated gene expression profiling

(2019) Hongwu Fan et al.   Molecular Medicine Reports

Conflicting Roles of 20-HETE in Hypertension and Stroke

(2019) Shashank Shekhar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cortisol and aldosterone responses to hypoglycemia and Na depletion in women with non-classic 21-hydroxylase deficiency

(2019) Peter Kamenický et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Minds, Maps, Meanderings

(2019) Craigan Usher   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Challenges and Opportunities for Childhood Cancer Drug Development

(2019) Peter J. Houghton et al.   PHARMACOLOGICAL REVIEWS

The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease

(2019) Isabel Weigl et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice

(2019) Sébastien Le Garf et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-urate transporter 1, non-glucose transporter member 9-related renal hypouricemia and acute renal failure accompanied by hyperbilirubinemia after anaerobic exercise: a case report

(2019) Yoshitaka Furuto et al.   BMC Nephrology

AChE mRNA expression as a possible novel biomarker for the diagnosis of coronary artery disease and Alzheimer’s disease, and its association with oxidative stress

(2019) Mesut Işık et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Frequent overexpression of klotho in fusion-negative phosphaturic mesenchymal tumors with tumorigenic implications

(2019) Cheng-Han Lee et al.   MODERN PATHOLOGY

A positive Helicobacter pylori test is associated with low spondylarthritis incidence in a Danish historical cohort study

(2019) Lars E. Bartels et al.   RHEUMATOLOGY INTERNATIONAL

Pazopanib in the Treatment of Bone Sarcomas: Clinical Experience

(2019) Ninna Aggerholm-Pedersen et al.   Translational Oncology

Effect of biologics in the level of cytokines in the synovial fluid of patients with ankylosing spondylitis

(2019) Bon San Koo et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis

(2018) Jianlong Gao et al.   CANCER SCIENCE

Post-Transcriptional Control of Angiotensin II Type 1 Receptor Regulates Osteosarcoma Cell Death

(2018) Yue Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1

(2018) Chen Chao et al.   EXPERIMENTAL CELL RESEARCH

The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease

(2018) Jiaqi Liu et al.   HUMAN GENETICS

Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors

(2018) Michal Kostas et al.   MOLECULAR & CELLULAR PROTEOMICS

Exploring the mechanistic insights of Cas scaffolding protein family member 4 with protein tyrosine kinase 2 in Alzheimer’s disease by evaluating protein interactions through molecular docking and dynamic simulations

(2018) Mubashir Hassan et al.   NEUROLOGICAL SCIENCES

Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature

(2018) Keita Kai et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular Docking and Dynamic Simulation of AZD3293 and Solanezumab Effects Against BACE1 to Treat Alzheimer's Disease

(2018) Mubashir Hassan et al.   Frontiers in Computational Neuroscience

SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia

(2018) LB Baughn et al.   Cancer Genetics

Establishment and characterization of the NCC–SS1–C1 synovial sarcoma cell line

(2018) Fusako Kito et al.   Human Cell

Ewing sarcoma

(2018) Thomas G. P. Grünewald et al.   Nature Reviews Disease Primers

Pazopanib in relapsed osteosarcoma patients: report on 15 cases

(2018) Alessandra Longhi et al.   ACTA ONCOLOGICA

Activation of the renin-angiotensin system in mice aggravates mechanical loading-induced knee osteoarthritis

(2018) Kotaro Yamagishi et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Prostate cancer tissues with positive TMPRSS2-ERG-gene-fusion status may display enhanced nerve density

(2018) Jörg Hänze et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Leveraging Polygenic Functional Enrichment to Improve GWAS Power

(2018) Gleb Kichaev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The exploration of novel Alzheimer’s therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches

(2018) Mubashir Hassan et al.   BIOMEDICINE & PHARMACOTHERAPY

Computational investigation of mechanistic insights of Aβ42 interactions against extracellular domain of nAChRα7 in Alzheimer’s disease

(2018) Mubashir Hassan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis

(2018) Unnur Styrkarsdottir et al.   NATURE GENETICS

Treating Osteosarcoma with CAR T cells

(2018) Hakan Köksal et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

APE1 stimulates EGFR-TKI resistance by activating Akt signaling through a redox-dependent mechanism in lung adenocarcinoma

(2018) Guo-Shou Lu et al.   Cell Death & Disease

MicroRNA-21 induces loss of 15-hydroxyprostaglandin dehydrogenase in early gastric tubular adenocarcinoma

(2018) Young Soo Park et al.   Scientific Reports

Gamma-Aminobutyric Acid (Gaba) Receptors Rho (Gabrr) Gene Polymorphisms and Risk for Migraine

(2017) Elena García-Martín et al.   HEADACHE

Elemene inhibits osteosarcoma growth by suppressing the renin‑angiotensin system signaling pathway

(2017) Lixiang Ding et al.   Molecular Medicine Reports

LncRNA FENDRR sensitizes doxorubicin-resistance of osteosarcoma cells through down-regulating ABCB1 and ABCC1

(2017) Zhu Kun-Peng et al.   Oncotarget

Influence of CYP2C9 and COX-2 Genetic Polymorphisms on Clinical Efficacy of Non-Steroidal Anti-Inflammatory Drugs in Treatment of Ankylosing Spondylitis

(2017) Yu Wang et al.   MEDICAL SCIENCE MONITOR

On the Integration of In Silico Drug Design Methods for Drug Repurposing

(2017) Eric March-Vila et al.   Frontiers in Pharmacology

Protein Binding Pocket Dynamics

(2016) Antonia Stank et al.   ACCOUNTS OF CHEMICAL RESEARCH

The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis

(2016) Igor Snapkov et al.   BMC CANCER

Leukotriene receptor expression in esophageal squamous cell cancer and non-transformed esophageal epithelium: a matched case control study

(2016) M. Venerito et al.   BMC GASTROENTEROLOGY

Rivaroxaban significantly inhibits the stimulatory effects of bone-modulating hormones: In vitro study of primary female osteoblasts

(2016) Dalia Somjen et al.   CONNECTIVE TISSUE RESEARCH

Activation of the pro-migratory bone morphogenetic protein receptor 1B gene in human MDA-MB-468 triple-negative breast cancer cells that over-express CYP2J2

(2016) Sarah E. Allison et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Multimodal transfer of MDR by exosomes in human osteosarcoma

(2016) ELENA TORREGGIANI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Association of SNPs in dopamine and serotonin pathway genes and their interacting genes with temperament traits in Charolais cows

(2016) E. Garza-Brenner et al.   JOURNAL OF APPLIED GENETICS

SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening

(2016) Vincent Zoete et al.   Journal of Chemical Information and Modeling

Microduplication of 7q36.3 encompassing the SHH long-range regulator (ZRS) in a patient with triphalangeal thumb-polysyndactyly syndrome and congenital heart disease

(2016) Zhenghua Liu et al.   Molecular Medicine Reports

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research

(2016) Paul W. Tetteh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucuronidation and UGT isozymes in bladder: new targets for the treatment of uroepithelial carcinomas?

(2016) Vikram L. Sundararaghavan et al.   Oncotarget

Exploration of Novel Human Tyrosinase Inhibitors by Molecular Modeling, Docking and Simulation Studies

(2016) Mubashir Hassan et al.   Interdisciplinary Sciences-Computational Life Sciences

Molecular Determinants of α-Synuclein Mutants’ Oligomerization and Membrane Interactions

(2015) Igor F. Tsigelny et al.   ACS Chemical Neuroscience

Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

(2015) Guang-Zhen Yang et al.   BMC CANCER

OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway

(2015) Elie Seaayfan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diagnosis and treatment of Ewing sarcoma of the bone: a review article

(2015) Toshifumi Ozaki   JOURNAL OF ORTHOPAEDIC SCIENCE

Silencing ofEag1Gene Inhibits Osteosarcoma Proliferation and Migration by Targeting STAT3-VEGF Pathway

(2015) Xinyu Wu et al.   Biomed Research International

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma

(2015) Florencia Cidre-Aranaz et al.   Frontiers in Oncology

Hypermethylation of the GABRE miR-452 miR-224 Promoter in Prostate Cancer Predicts Biochemical Recurrence after Radical Prostatectomy

(2014) H. Kristensen et al.   CLINICAL CANCER RESEARCH

Targeted next-generation sequencing in the diagnosis of neurodevelopmental disorders

(2014) N. Okamoto et al.   CLINICAL GENETICS

Chronic Ingestion of H1-Antihistamines Increase Progression of Atherosclerosis in Apolipoprotein E-/- Mice

(2014) Vineesh V. Raveendran et al.   PLoS One

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Influence of CYP2D6-genotype on tamoxifen efficacy in advanced breast cancer

(2013) Jennifer Karle et al.   BREAST CANCER RESEARCH AND TREATMENT

A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci

(2013) Jose-Ezequiel Martin et al.   HUMAN MOLECULAR GENETICS

The role of KCNQ1 in mouse and human gastrointestinal cancers

(2013) B L N Than et al.   ONCOGENE

Initial Exploration of Oral Pazopanib in Healthy Participants and Patients With Age-Related Macular Degeneration

(2013) Megan M. McLaughlin et al.   JAMA Ophthalmology

Ether à go-go 1 Silencing in Combination with TRAIL Overexpression Has Synergistic Antitumor Effects on Osteosarcoma

(2012) Jin Wu et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1  Interaction with Cofactors p300/CBP

(2012) S. Yin et al.   CLINICAL CANCER RESEARCH

Functional characterization of protein variants of the human multidrug transporter ABCC2 by a novel targeted expression system in fibrosarcoma cells

(2012) Rudolf Arlanov et al.   HUMAN MUTATION

Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial

(2012) Winette TA van der Graaf et al.   LANCET

Effect of Costunolide and Dehydrocostus Lactone on Cell Cycle, Apoptosis, and ABC Transporter Expression in Human Soft Tissue Sarcoma Cells

(2012) Nadine Kretschmer et al.   PLANTA MEDICA

Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases

(2012) Erik G. Puffenberger et al.   PLoS One

Epigenetic maintenance of stemness and malignancy in peripheral neuroectodermal tumors by EZH2

(2011) Stefan Burdach et al.   CELL CYCLE

Identification of Genes with Allelic Imbalance on 6p Associated with Nasopharyngeal Carcinoma in Southern Chinese

(2011) Yan Li et al.   PLoS One

Genetic Determinants of UV-Susceptibility in Non-Melanoma Skin Cancer

(2011) Marleen M. Welsh et al.   PLoS One

Cell-specific differences in the processing of the R14W CAIV mutant associated with retinitis pigmentosa 17

(2010) Aisha Pandor et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Optimizing working parameters of the smooth particle mesh Ewald algorithm in terms of accuracy and efficiency

(2010) Han Wang et al.   JOURNAL OF CHEMICAL PHYSICS

A Phase 1 Trial and Pharmacokinetic Study of Cediranib, an Orally Bioavailable Pan–Vascular Endothelial Growth Factor Receptor Inhibitor, in Children and Adolescents With Refractory Solid Tumors

(2010) Elizabeth Fox et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder

(2010) D M Cannon et al.   MOLECULAR PSYCHIATRY

Heparanase participates in the growth and invasion of human U-2OS osteosarcoma cells and its close relationship with hypoxia-inducible factor-1α in osteosarcoma

(2010) C. ZENG et al.   NEOPLASMA

Advances in Ewing's Sarcoma Research: Where Are We Now and What Lies Ahead?

(2009) J. L. Ordonez et al.   CANCER RESEARCH

Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats

(2009) Hideo Shimizu et al.   HYPERTENSION RESEARCH

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

An Improved United Atom Force Field for Simulation of Mixed Lipid Bilayers

(2009) See-Wing Chiu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Angiotensin receptor gene polymorphisms and 2-year change in hyperintense lesion volume in men

(2009) W D Taylor et al.   MOLECULAR PSYCHIATRY

Pharmacogenomics of adverse drug reactions: practical applications and perspectives

(2009) Laurent Becquemont   PHARMACOGENOMICS

The CYP3A4*18 Genotype in the Cytochrome P450 3A4 Gene, a Rapid Metabolizer of Sex Steroids, Is Associated With Low Bone Mineral Density

(2008) YS Kang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Blockade of the RhoA-JNK-c-Jun-MMP2 Cascade by Atorvastatin Reduces Osteosarcoma Cell Invasion

(2008) Olivia Fromigué et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lumbar disc disease shows linkage to chromosome 19 overlapping with a QTL for hand OA

(2007) F M K Williams et al.   ANNALS OF THE RHEUMATIC DISEASES