Article
Food Science & Technology
Cui-Cui Sun, Zhong-Ping Yin, Ji-Guang Chen, Wen-Jun Wang, Guo-Dong Zheng, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang
Summary: The study found that dihydromyricetin can improve cognitive impairment in d-galactose-induced aging mice by regulating oxidative stress and inhibiting acetylcholinesterase.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Chemistry, Medicinal
Xin Wang, Tao Zhang, Xiaochen Chen, Yating Xu, Zhipeng Li, Yuanfan Yang, Xiping Du, Zedong Jiang, Hui Ni
Summary: All-trans astaxanthin, derived mainly from marine organisms, showed a strong inhibitory effect on acetylcholinesterase and oxidative stress. It acted as a reversible competitive inhibitor with a half inhibitory concentration (IC50 value) of 8.64 mu mol/L. Additionally, all-trans astaxanthin reduced oxidative stress by decreasing malondialdehyde content and increasing the activity of superoxide dismutase and catalase. It also induced changes in the secondary structure of acetylcholinesterase to reduce its activity. Molecular-docking analysis revealed that all-trans astaxanthin prevented substrate binding to acetylcholinesterase by occupying the active pocket space.
Article
Neurosciences
Raghavan Pillai Raju, Lun Cai, Alpna Tyagi, Subbiah Pugazhenthi
Summary: In this study, using RNA-seq analysis, we found significant changes in gene expression related to pathways including oxidation-reduction, oxidative phosphorylation, innate immune response, ribosomal protein synthesis, and ubiquitin proteosome system in the brains of 5XFAD mice. The downregulation of genes related to oxidation-reduction and upregulation of immune response genes were the most striking features observed. Gene interaction analysis revealed at least three distinct interaction clusters, with the predominant one relating to cellular energetics.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Sukanya Bhunia, Nagesh Kolishetti, Adriana Yndart Arias, Arti Vashist, Madhavan Nair
Summary: Despite challenges in finding a cure for neurodegenerative diseases, phytocannabinoids from cannabis, especially CBD, have emerged as potential neurotherapeutics due to their antioxidant and anti-inflammatory properties. These compounds have shown promise in protecting the nervous system from inflammation and oxidative stress, particularly in diseases like Parkinson's and Alzheimer's.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mario A. Tan, Niti Sharma, Seong Soo A. An
Summary: Plant-derived carbazole alkaloids are important compounds that have potential neuroprotective effects in ameliorating neurodegenerative diseases.
Review
Chemistry, Multidisciplinary
Julian Szymanski, Dominik Szwajgier, Ewa Baranowska-Wojcik
Summary: Beets are a rich source of bioactive compounds such as betalain pigments, phenols, and saponins. These compounds exhibit neuroprotective properties due to their antioxidant activity, anti-inflammatory effects, and ability to lower the activity of acetylcholinesterase. Betanin, the most common pigment in beetroot, has been shown to have antioxidant activity and can protect neurons against peroxidation. Phenolic compounds in beetroots, including gallic, ferulic, and vanillic acids, also have similar protective effects. The administration of betanin has been found to reverse artificially induced neurodegenerative diseases, while vanillic acid has been shown to improve spatial learning ability. Processed beetroot products like juices and jams can be beneficial in preventing and supporting therapy for neurodegenerative diseases like Alzheimer's.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Panka Pinter, Alan Alpar
Summary: The focus of this study is on changes in the extracellular matrix in neurodegenerative disorders. The composition of the extracellular matrix is critical for neuronal function, and changes in its assembly can trigger or reflect dysfunction in the brain/spinal cord. The study summarizes the phenotypic appearance, biochemical characteristics, and major enzymes involved in regulating and remodeling the extracellular matrix in disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mahshid Hesar Shourkabi, Maryam Ghobeh, Hanieh Jafary
Summary: Alzheimer's disease is a common neurodegenerative disease characterized by memory loss and cognitive impairment. A newly synthesized molecule called benzenesulfonamide has been found to affect oxidative biomarkers and the expression of beta-amyloid peptides in the pathology of AD. When administered to rats with Alzheimer's, benzenesulfonamide significantly increased the levels of oxidative biomarkers and amyloid gene expressions. Therefore, it could be a potential therapeutic agent for Alzheimer's disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Neurosciences
Rong Yang, Xinxing Yang, Feng Zhang
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, cerebral amyloid angiopathy, and Huntington's disease, are characterized by cognitive and motor dysfunctions and neurodegeneration. These diseases have become more severe over time and cannot be cured currently. Taxifolin, a compound derived from Douglas fir and Larix gemelini, has been confirmed to exhibit various pharmacological activities and has shown potential in the treatment of neurodegenerative diseases.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nur Hanisah Azmi, Norsharina Ismail, Mustapha Umar Imam, Der Jiun Ooi, Siti Nur Hazwani Oslan
Summary: This study investigates the neuroprotective effect of germinated brown rice ethyl acetate extract (GBR-EA) on oxidative changes induced by a high-fat diet (HFD) in rats. GBR-EA supplementation improves lipid profile and serum antioxidant status, regulates the expression of antioxidant and inflammatory genes, and attenuates pro-inflammatory changes in the hippocampus. This study highlights the potential of GBR-EA to ameliorate neurodegenerative processes resulting from high cholesterol consumption.
Review
Chemistry, Medicinal
Sibel Suzen, Paolo Tucci, Elisabetta Profumo, Brigitta Buttari, Luciano Saso
Summary: Neurodegenerative diseases are characterized by high levels of oxidative stress biomarkers and low levels of antioxidant protection; Dysregulation of the oxidant/antioxidant balance is a major factor in the pathogenesis of these diseases; Nrf2 plays a protective and defending role against neurodegenerative conditions.
Article
Immunology
Yingying Nie, Jingming Yang, Longjian Zhou, Zhiyou Yang, Jinyue Liang, Yayue Liu, Xiaoxiang Ma, Zhongji Qian, Pengzhi Hong, Allan Kalueff, Cai Song, Yi Zhang
Summary: In this study, BTL-I was found to be a potential therapeutic agent for preventing CNS deficits caused by inflammation, neurotoxicity, and gut flora imbalance.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Neurosciences
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: Psoriasis, a chronic skin disease, has been investigated for its potential links to neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The analysis revealed some potential connections, including inflammation, oxidative stress, genetics, and cardiometabolic disorders. However, there is currently no strong evidence to suggest that psoriasis predisposes individuals to neurodegenerative diseases. Further research is needed to confirm these findings.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Grammatiki Alexandra Sidiropoulou, Athanasios Metaxas, Malamati Kourti
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that causes dementia in older adults. Oxidative stress is a contributing factor to AD, and natural antioxidants have potential therapeutic effects. The transcription factor NRF2 plays a key role in the antioxidant response, and recent research has focused on the NRF2-modulating activity of natural antioxidants in AD models.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ratnakar Jadhav, Yogesh A. Kulkarni
Summary: Recent evidences suggest a rise in global cases of dementia, with Alzheimer's disease being the leading cause. Quercetin, a flavonoid, has shown potential therapeutic benefits including neuroprotective effects. This study evaluates the neuroprotective effect of orally administered quercetin with memantine in albino Wistar rats after induction of neurotoxicity. The results demonstrate that the treatment of quercetin with memantine improves behavioral parameters, reduces oxidative stress, inhibits amyloid-beta plaque formation, and enhances the expression of brain-derived neurotrophic factor (BDNF).
Article
Biochemistry & Molecular Biology
Parham Taslimi, Mesut Isik, Fikret Turkan, Mustafa Durgun, Cuneyt Turkes, Ilhami Gulcin, Sukru Beydemir
Summary: Sulfonamide derivatives have a wide range of biological activities and potential as medical molecules in drug development. Studies have shown that these compounds have an impact on various enzymes. The synthesized derivatives demonstrate inhibitory effects on AChE, GST, and α-GLY enzymes, with stronger inhibition observed at lower concentrations through the addition of functional electronegative groups.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Mesut Isik, Sukru Beydemir
Summary: The study revealed that hydroquinone, chlorogenic acid, and 4-hydroxybenzoic acid have higher inhibitory potential against AChE, making them potential alternative drugs for the treatment of Alzheimer's disease.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Abdurrahman Akdag, Mesut Isik, Hasan Goktas
Summary: A voltammetric biosensor for detecting ATCh and paraoxon was successfully developed with good storage stability and operational stability. The linear range for ATCh was 30-50 mu M and 0.46-1.84 nM for paraoxon, with detection limits of 0.45 mu M and 0.17 nM, respectively.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Suleyman Akocak, Parham Taslimi, Nebih Lolak, Mesut Isik, Mustafa Durgun, Yakup Budak, Cuneyt Turkes, Ilhami Gulcin, Sukru Beydemir
Summary: A series of novel ureido-substituted sulfaguanidine derivatives were synthesized and their inhibitory effects on alpha-glycosidase, acetylcholinesterase, and butyrylcholinesterase enzymes associated with diabetes mellitus and Alzheimer's disease were investigated. The compounds showed higher antidiabetic effects compared to their anti-Alzheimer's effects, with stronger inhibition on the diabetic enzyme alpha-GLY than on esterase enzymes. Inhibition of metabolic enzymes is important for the treatment of DM and AD.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Biochemistry & Molecular Biology
Cuneyt Turkes, Suleyman Akocak, Mesut Isik, Nebih Lolak, Parham Taslimi, Mustafa Durgun, Ilhami Gulcin, Yakup Budak, Sukru Beydemir
Summary: A series of novel ureido-substituted derivatives with sulfamethazine backbone were investigated for the inhibition of AChE, BChE, and alpha-GLY. Among these derivatives, compound 2c showed the most potent inhibition profile towards AChE and BChE. The study suggests the potential use of inhibitors with sulfamethazine backbone as innovative anticholinergic and antidiabetic agents.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Plant Sciences
Jameel M. Al-Khayri, Arzu Kavaz Yuksel, Mehmet Yuksel, Mesut Isik, Emrah Dikici
Summary: Corn tassel (CT) is a waste part of the corn plant that contains bioactive compounds and phytochemicals. This research analyzed the phenolic profile, antioxidants, anticholinergic activities, and antibacterial properties of CT ethanol extract. The results showed that the ethanol extract of CT contains various phenolic compounds and exhibits strong antioxidant and antibacterial activities.
Article
Biochemistry & Molecular Biology
Arzu Kavaz, Mesut Isik, Emrah Dikici, Mehmet Yuksel
Summary: This study analyzed the phytochemical component content, anticholinergic and antioxidant activities, and antibacterial properties of Vitex agnus-castus seed ethanol extracts. The results showed that the seeds contained various phenolic compounds and exhibited strong antioxidant and antibacterial activities. Therefore, Vitex agnus-castus seed could be a promising natural antioxidant and antibacterial candidate.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Nebih Lolak, Suleyman Akocak, Mustafa Durgun, Hatice Esra Duran, Adem Necip, Cuneyt Turkes, Mesut Isik, Sukru Beydemir
Summary: To discover alternative substances for treating Alzheimer's and Parkinson's disease, a series of novel derivatives were synthesized and their inhibitory capacities were evaluated against specific enzymes. The results showed high inhibitory activity and radical scavenging capabilities, which are important for the rational design and synthesis of new multifunctional inhibitors.
MOLECULAR DIVERSITY
(2023)
Article
Computer Science, Interdisciplinary Applications
Kevser Kubra Kirboga, Ecir Ugur Kucuksille, Muhammet Emin Naldan, Mesut Isik, Oktay Gulcu, Emrah Aksakal
Summary: This study used explainable white box algorithms to diagnose Troponin levels in the COVID-19 process in order to provide a clear explanation. The SHAP algorithm was applied to analyze the model and determine the highest importance of features such as DDimer mean, mortality, CKMB, and Glucose.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Suleyman Akocak, Nebih Lolak, Hatice Esra Duran, Mesut Isik, Cuneyt Turkes, Mustafa Durgun, Sukru Beydemir
Summary: In this study, a series of novel 1,3-diaryltriazene-substituted sulfaguanidine derivatives (SG1-13) were synthesized and screened for their inhibitory effect on human carbonic anhydrase (hCA) I and hCA II. These compounds showed potential as selective hCA inhibitors, with binding affinity demonstrated through in silico studies. They may serve as alternative agents for the treatment or prevention of diseases associated with glaucoma and hCA inhibition.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Cell Biology
Mesut Isik, Abdullah Tunc, Hatice Esra Duran, Muhammet Emin Naldan, Aslan Yilmaz, Mehmet Nuri Kocak, Sukru Beydemir
Summary: This study investigated the role of antioxidant status associated with oxidative stress in Alzheimer's disease. The results showed that the activity of several enzymes was reduced in Alzheimer's patients, and the expression levels of glutathione S-transferase and presenilin 1 genes were increased.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Food Science & Technology
Adem Necip, Ibrahim Demirtas, Secil Erden Tayhan, Mesut Isik, Sema Bilgin, Ismail Furkan Turan, Yasar Ipek, Suekrue Beydemir
Summary: This study presents the first findings on the effects of propolis water extract on oral mucosal wound healing and the potential antioxidant and anti-Alzheimer properties of its isolated compounds.
FOOD SCIENCE & NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Arzu Kavaz Yuksel, Emrah Dikici, Mehmet Yuksel, Mesut Isik
Summary: This research investigated the antioxidant, antibacterial, and anticholinergic properties of Abelmoschus esculentus ethanol extract. Phenolic analysis revealed the presence of various phenolic compounds. The ethanol extract showed promising antioxidant and antibacterial activities, with significant inhibition of AChE.
KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE
(2022)
Article
Cardiac & Cardiovascular Systems
Mesut Isik, Abdullah Tunc, Sukru Beydemir
Summary: This study investigated the role of PSEN1, CAT, and GST in the prediction, diagnosis, and therapy of metabolic disorders. The results showed significant differences in the expression of PSEN1, CAT, and GST between the patient group and the control group. The expression of PSEN1 in leukocytes was twice as high in patients with CVD compared to the control group. The activity of GST, CAT, and PON1 also differed significantly between the patient groups and the control group.
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
(2022)
