Review
Medicine, General & Internal
Stefan K. Zoellner, James E. Amatruda, Sebastian Bauer, Stephane Collaud, Enrique de Alava, Steven G. DuBois, Jendrik Hardes, Wolfgang Hartmann, Heinrich Kovar, Markus Metzler, David S. Shulman, Arne Streitbuerger, Beate Timmermann, Jeffrey A. Toretsky, Yasmin Uhlenbruch, Volker Vieth, Thomas G. P. Gruenewald, Uta Dirksen
Summary: Ewing sarcoma is a highly aggressive bone and soft-tissue cancer with a genetically simple yet specific therapeutic target. Current standard treatment involving systemic therapy and local treatment provides a realistic chance of cure for the majority of patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Philip Heesen, Andreas Ranft, Vivek Bhadri, Benedicte Brichard, Stephane Collaud, Sona Cyprova, Hans Eich, Torben Ek, Hans Gelderblom, Jendrik Hardes, Lianne Haveman, Susanne Jabar, Wolfgang Hartmann, Dimosthenis Andreou, Peter Hauser, Josephine Kersting, Heribert Juergens, Jukka Kanerva, Thomas Kuehne, Anna Raciborska, Jelena Rascon, Arne Streitbuerger, Beate Timmermann, Yasmin Uhlenbruch, Uta Dirksen
Summary: This study analyzed the association between local therapy and event-free survival (EFS), overall survival (OS), and local recurrence (LR) in patients with Ewing sarcoma. The results showed that in certain situations, combination therapy with radiotherapy and surgery can improve the prognosis of patients. This provides important evidence for the personalized treatment of Ewing sarcoma.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Health Care Sciences & Services
J. Berger-Groch, M. Keitsch, A. Reiter, S. Weiss, KH. Frosch, M. Priemel
Summary: The use of mobile applications in orthopaedic and trauma surgery, particularly for musculoskeletal tumors, is increasing rapidly, with a wide range of applications available in the App/Play Stores. Despite the limited number of scientific articles on this topic, the development of new mobile applications in this field is ongoing. It is important to continuously evaluate the significance and effectiveness of these applications in order to keep up with advancements in orthopaedic oncology.
JOURNAL OF MEDICAL SYSTEMS
(2021)
Article
Oncology
Matthew T. T. Houdek, Mark J. J. Heidenreich, Safia K. K. Ahmed, Wendy Allen-Rhoades, Brittany L. L. Siontis, Steven I. I. Robinson, Ivy A. A. Petersen, Peter S. S. Rose
Summary: The study evaluated the treatment experience of EES patients and found that chemotherapy and surgery can achieve excellent local control.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Fabian M. Troschel, Kai Kroeger, Jan J. Siats, Kambiz Rahbar, Hans Theodor Eich, Sergiu Scobioala
Summary: This study evaluates the role of cranio-spinal irradiation (CSI) in the treatment of primary extraosseous intraspinal Ewing sarcoma (EwS). The results demonstrate promising outcomes with CSI, despite the presence of unfavorable characteristics such as multifocal lesions and intradural tumor location. Treatment should be individualized based on tumor and patient characteristics in the absence of prospective trials.
Review
Otorhinolaryngology
Rafey Rehman, Muhammad Osto, Nathan Parry, Nadeen Awada, Jacob Agemy, Khashayar Arianpour, Adam J. Folbe
Summary: This study conducted a systematic review on the demographics, characteristics, management, treatment, complications, and outcomes of Ewing sarcomas in the craniofacial bones. It found that the most common affected locations were the frontal bone, nasal cavity, and temporal bone, with common treatment strategies involving combinations of surgical intervention, radiotherapy, and chemotherapy. Patients who received a combination of surgical intervention/radiotherapy/chemotherapy experienced a local recurrence rate of 16.6%.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Medicine, General & Internal
Stefania Kokkali, Anastasios Kyriazoglou, Elpida Mangou, Panagiota Economopoulou, Michail Panousieris, Amanda Psyrri, Alexandros Ardavanis, Nikolaos Vassos, Ioannis Boukovinas
Summary: Retrospective analysis showed that cabozantinib has antitumor activity in adult patients with advanced bone sarcoma and ES/primitive neuroectodermal tumors, but no significant objective response rate was observed. Common adverse events in clinical practice included fatigue, anorexia, hypertransaminasemia, weight loss, and diarrhea.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Evangelos Koustas, Panagiotis Sarantis, Michalis V. Karamouzis, Philippe Vielh, Stamatios Theocharis
Summary: Ewing Sarcoma is a rare and aggressive cancer in children and young adults, with controversial role of autophagy being explored in clinical trials. Caution is recommended in the application of autophagy as a therapeutic target, and future studies are needed to identify which patients may benefit from autophagy modulators for more efficient treatment protocols.
Review
Biochemistry & Molecular Biology
Zeger Rijs, Bernadette Jeremiasse, Naweed Shifai, Hans Gelderblom, Cornelis F. M. Sier, Alexander L. Vahrmeijer, Fijs W. B. van Leeuwen, Alida F. W. van der Steeg, Michiel A. J. van de Sande
Summary: The article discusses the types and treatment methods of pediatric sarcomas, emphasizing the importance of surgical resection and suggesting that fluorescence-guided surgery may facilitate complete tumor removal. Evaluation of non-targeted and targeted FGS is presented, demonstrating their potential benefits and challenges in pediatric OS, ES, and RMS patients.
Review
Oncology
Abdallah Abboud, Karim Masrouha, Maelle Saliba, Rachid Haidar, Raya Saab, Nabil Khoury, Ayman Tawil, Said Saghieh
Summary: Extraskeletal Ewing sarcoma (EES) is a rare primary tumor of soft tissues, following similar treatment protocols as sarcoma tumors. Diagnosis relies on clinical features and imaging, with magnetic resonance imaging as the preferred modality. More research is needed to determine the optimal treatment for EES.
Article
Immunology
Wen Luo, Hai Hoang, Yanling Liao, Jian Pan, Janet Ayello, Mitchell S. Cairo
Summary: A humanized mouse model for Ewing sarcoma has been developed, allowing for functional reconstitution of the human immune system and evaluation of immunotherapy. This model holds promise for translational research in bone malignancies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Kevin M. Campbell, David S. Shulman, Holcombe E. Grier, Steven G. DuBois
Summary: The study found a 4.8% incidence of bone marrow metastasis (BMM) in newly diagnosed Ewing sarcoma patients, and a higher rate of 17.5% among patients with metastatic disease. Only a small percentage of patients (1.2%) had BMM as their sole metastatic site. FDG-PET showed high accuracy for detecting BMM compared to BMBA.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Oncology
Jonathan Metts, Thomas Russell, Damon Reed, Matteo Trucco
Summary: Metastatic Ewing sarcoma has poor cure rates and requires novel treatment strategies. This article proposes a clinical trial based on evolutionary oncology principles to treat Ewing sarcoma. The trial will investigate a treatment approach called sequential second-strike therapy (SSST), which varies exposure to drugs and dosing intensities. The aim is to improve outcomes for patients with widely metastatic Ewing sarcoma, beyond the lungs.
Article
Medicine, General & Internal
Khaled Ali, Mhd Baraa Habib, Noheir M. Taha, Ahmed M. Abdalhadi, Riyadh Hammamy
Summary: Pleural effusion can rarely be the initial presentation of Ewing sarcoma, as illustrated by a case of a young male adult whose diagnosis was made following admission for pleural effusion.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Oncology
Patcharapol Arunwatthanangkul, Panichanok Piyabenjarad, Siraprapa Wisitthipakdeekul, Thanapon Chobpenthai
Summary: A 13-year-old boy presented with a growing lump on his left clavicle for 5 months. Further examinations revealed Ewing sarcoma without metastasis. The patient underwent two-stage surgery and received a personalized 3D-printed titanium implant, resulting in remission and intact shoulder function.
FRONTIERS IN ONCOLOGY
(2023)