Prospective Application of Ferroptosis in Hypoxic Cells for Tumor Radiotherapy

Ferroptosis‐related gene NOX4 , CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma

(2022) Ruoxi Xiao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The PER1/HIF-1alpha negative feedback loop promotes ferroptosis and inhibits tumor progression in oral squamous cell carcinoma

(2022) Yixin Yang et al.   Translational Oncology

Hypoxia Enhances HIF1α Transcription Activity by Upregulating KDM4A and Mediating H3K9me3, Thus Inducing Ferroptosis Resistance in Cervical Cancer Cells

(2022) Jing Xiong et al.   Stem Cells International

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

HIF‐1α downregulation of miR‐433‐3p in adipocyte‐derived exosomes contributes to NPC progression via targeting SCD1

(2021) Haimeng Yin et al.   CANCER SCIENCE

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

(2021) Qiujie Wang et al.   Cell Death & Disease

Ferroptosis, radiotherapy, and combination therapeutic strategies

(2021) Guang Lei et al.   Protein & Cell

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis

(2021) Shuo Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

IL‐1β‐Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up‐regulating Programmed Death Ligand 1 and Colony‐Stimulating Factor 1

(2021) Qin He et al.   HEPATOLOGY

MiR-7-5p Is Involved in Ferroptosis Signaling and Radioresistance Thru the Generation of ROS in Radioresistant HeLa and SAS Cell Lines

(2021) Kazuo Tomita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF‐1α/SLC7A11 pathway

(2021) Siyu Yuan et al.   CELL PROLIFERATION

D‐mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF‐2α‐dependent manner

(2021) Xueman Zhou et al.   CELL PROLIFERATION

Radiosensitizer Effect of β-Apopicropodophyllin against Colorectal Cancer via Induction of Reactive Oxygen Species and Apoptosis

(2021) Jin-Hee Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia blocks ferroptosis of hepatocellular carcinoma via suppression of METTL14 triggered YTHDF2‐dependent silencing of SLC7A11

(2021) Zhuoyang Fan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Construction and Validation of a Combined Ferroptosis and Hypoxia Prognostic Signature for Hepatocellular Carcinoma

(2021) Kai Wen et al.   Frontiers in Molecular Biosciences

Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury

(2021) Wenyuan Li et al.   Cell Death Discovery

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis

(2020) Khatereh Khorsandi et al.   Cancer Cell International

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats

(2020) Jing Yu et al.   Oxidative Medicine and Cellular Longevity

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

(2020) Yingchuan Li et al.   CELL DEATH AND DIFFERENTIATION

Activation of AMPK under Hypoxia: Many Roads Leading to Rome

(2020) Franziska Dengler   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2‐related programmed cell death in an AMPK‐dependent manner

(2020) Chunyan Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SIRT3 deficiency is resistant to autophagy‐dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels

(2020) Dandan Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

(2020) Dominik C. Fuhrmann et al.   Redox Biology

NRF2 and hypoxia inducible factors: key players in the redox control of systemic iron homeostasis

(2020) Tiago L Duarte et al.   ANTIOXIDANTS & REDOX SIGNALING

Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway

(2020) Zhixian Gou et al.   BRAIN RESEARCH BULLETIN

HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer

(2020) Ellen C. de Heer et al.   JOURNAL OF CLINICAL INVESTIGATION

2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

(2020) Naoyoshi Koike et al.   Communications Biology

The Molecular Mechanisms of Regulating Oxidative Stress-Induced Ferroptosis and Therapeutic Strategy in Tumors

(2020) Jinghan Zhu et al.   Oxidative Medicine and Cellular Longevity

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

(2020) Youbo Zhao et al.   Cell Reports

Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4‑mediated ferroptosis

(2019) Xiaofen Pan et al.   Oncology Letters

Hypoxic Radioresistance: Can ROS Be the Key to Overcome It?

(2019) Hui Wang et al.   Cancers

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy

(2019) Najah Albadari et al.   Expert Opinion on Drug Discovery

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

(2019) Lian-Jiu Su et al.   Oxidative Medicine and Cellular Longevity

Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo

(2019) Yuki Shibata et al.   PLoS One

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

(2018) Heike Miess et al.   ONCOGENE

Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

(2018) Masaki Nagane et al.   PLoS One

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway

(2018) Yun Zhou et al.   Cancer Medicine

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Cisplatin Chemoradiotherapy vs Radiotherapy in FIGO Stage IIIB Squamous Cell Carcinoma of the Uterine Cervix

(2018) Shyamkishore Shrivastava et al.   JAMA Oncology

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction

(2018) Lara Cobler et al.   Oncotarget

Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma

(2018) Miyong Yun et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial

(2018) Maura L Gillison et al.   LANCET

Role of HIF-1α in response of tumors to a combination of hyperthermia and radiation in vivo

(2017) Wonwoo Kim et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

The Nrf2/GCH1/BH4 Axis Ameliorates Radiation-Induced Skin Injury by Modulating the ROS Cascade

(2017) Jiao Xue et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Metabolic reprogramming in clear cell renal cell carcinoma

(2017) Hiromi I. Wettersten et al.   Nature Reviews Nephrology

EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes

(2017) Yiqun Jiang et al.   Theranostics

Redox signaling during hypoxia in mammalian cells

(2017) Kimberly A. Smith et al.   Redox Biology

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

(2016) Kimberly J. Briggs et al.   CELL

Inhibition of Notch and HIF enhances the antitumor effect of radiation in Notch expressing lung cancer

(2016) Yasuyuki Ikezawa et al.   International Journal of Clinical Oncology

HIF-1α triggers long-lasting glutamate excitotoxicity via system xc − in cerebral ischaemia-reperfusion

(2016) Chia-Hung Hsieh et al.   JOURNAL OF PATHOLOGY

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

(2016) Meng-Chen Lu et al.   MEDICINAL RESEARCH REVIEWS

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

TGF-βand Hypoxia/Reoxygenation Promote Radioresistance of A549 Lung Cancer Cells through Activation of Nrf2 and EGFR

(2016) Sae-lo-oom Lee et al.   Oxidative Medicine and Cellular Longevity

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion

(2015) L Sleire et al.   ONCOGENE

Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function

(2015) LIANGYU CHEN et al.   ONCOLOGY REPORTS

The role of hypoxia-inducible factor-2 in digestive system cancers

(2015) J Zhao et al.   Cell Death & Disease

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

AMP-activated protein kinase (AMPK)-dependent and -independent pathways regulate hypoxic inhibition of transepithelial Na+ transport across human airway epithelial cells

(2012) CD Tan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

(2012) Si-Eun Yoo et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Phase I Study of the Combination of Sorafenib With Temozolomide and Radiation Therapy for the Treatment of Primary and Recurrent High-Grade Gliomas

(2012) Robert B. Den et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling

(2012) Rui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

(2011) Nobuhiko Harada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The ferroxidase center is essential for ferritin iron loading in the presence of phosphate and minimizes side reactions that form Fe(III)-phosphate colloids

(2011) Robert J. Hilton et al.   BIOMETALS

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles

(2011) Abena S. Agyeman et al.   BREAST CANCER RESEARCH AND TREATMENT

NRF2 Blockade Suppresses Colon Tumor Angiogenesis by Inhibiting Hypoxia-Induced Activation of HIF-1 

(2011) T.-H. Kim et al.   CANCER RESEARCH

A phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: A gynecologic oncology group study

(2011) David H. Moore et al.   GYNECOLOGIC ONCOLOGY

Hypoxic preconditioning involves system Xc− regulation in mouse neural stem cells

(2011) Brian Sims et al.   Stem Cell Research

Role of hypoxia in the hallmarks of human cancer

(2009) Kai Ruan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α and HIF-2α have divergent roles in colon cancer

(2008) Takaaki Imamura et al.   INTERNATIONAL JOURNAL OF CANCER