Radiosensitizer Effect of β-Apopicropodophyllin against Colorectal Cancer via Induction of Reactive Oxygen Species and Apoptosis

Colorectal cancer statistics, 2020

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Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers

(2020) Amy M. Buckley et al.   Nature Reviews Gastroenterology & Hepatology

Targeting apoptosis in cancer therapy

(2020) Benedito A. Carneiro et al.   Nature Reviews Clinical Oncology

β-Apopicropodophyllin functions as a radiosensitizer targeting ER stress in non-small cell lung cancer

(2019) Ju Yeon Kim et al.   BIOMEDICINE & PHARMACOTHERAPY

Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis

(2019) Hironobu Yasui et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Topoisomerases as anticancer targets

(2018) Justine L. Delgado et al.   BIOCHEMICAL JOURNAL

Cancer Radiosensitizers

(2018) Hao Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting antioxidant enzymes as a radiosensitizing strategy

(2018) Heng Jiang et al.   CANCER LETTERS

A novel anti-cancer role of β-apopicropodophyllin against non-small cell lung cancer cells

(2018) Ju Yeon Kim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Recent developments in topoisomerase targeted cancer chemotherapy

(2018) KirkE. Hevener et al.   Acta Pharmaceutica Sinica B

AMRI-59 functions as a radiosensitizer via peroxiredoxin I-targeted ROS accumulation and apoptotic cell death induction

(2017) Wan Gi Hong et al.   Oncotarget

Combination therapy in combating cancer

(2017) Reza Bayat Mokhtari et al.   Oncotarget

Predictors of chemotherapy efficacy in non-small-cell lung cancer: a challenging landscape

(2016) K. A. Olaussen et al.   ANNALS OF ONCOLOGY

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

(2016) P. Hornyak et al.   BIOCHEMICAL JOURNAL

Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan

(2016) Cornelia Meisenberg et al.   NUCLEIC ACIDS RESEARCH

Luteolin acts as a radiosensitizer in non-small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade

(2015) HYUN-JI CHO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Podophyllotoxin acetate triggers anticancer effects against non-small cell lung cancer cells by promoting cell death via cell cycle arrest, ER stress and autophagy

(2015) JAE YEON CHOI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Catalytic Core of Human Topoisomerase IIα: Insights into Enzyme–DNA Interactions and Drug Mechanism

(2014) R. Hunter Lindsey et al.   BIOCHEMISTRY

Gamma histone 2AX (γ-H2AX)as a predictive tool in radiation oncology

(2014) Stamatia Pouliliou et al.   BIOMARKERS

Type IA topoisomerase inhibition by clamp closure

(2013) Majety Naga Leelaram et al.   FASEB JOURNAL

Epigenetic and genetic features of 24 colon cancer cell lines

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Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

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Mitochondria and cell death: outer membrane permeabilization and beyond

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 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

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