The role of hypoxia-inducible factor-2 in digestive system cancers

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

(2014) Nathalie M. Mazure et al.   Autophagy

Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses

(2014) Haejin Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells

(2014) Dali Zhao et al.   CELLULAR SIGNALLING

PanIN-Specific Regulation of Wnt Signaling by HIF2  during Early Pancreatic Tumorigenesis

(2013) A. Criscimanna et al.   CANCER RESEARCH

HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

(2013) Chen-Ye Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibition of Hypoxia-Induced Gene Transcription by Substituted Pyrazolyl Oxadiazoles: Initial Lead Generation and Structure-Activity Relationships

(2013) Michael Härter et al.   ChemMedChem

The Correlation of Expression Levels of HIF-1  and HIF-2  in Hepatocellular Carcinoma with Capsular Invasion, Portal Vein Tumor Thrombi and Patients' Clinical Outcome

(2013) S.-L. Yang et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Downregulation of PHLPP Expression Contributes to Hypoxia-Induced Resistance to Chemotherapy in Colon Cancer Cells

(2013) Yang-An Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

(2012) Cristina Branco-Price et al.   CANCER CELL

Hypoxia-inducible factor-2  is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer

(2012) X. Xue et al.   CARCINOGENESIS

Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway

(2012) Hai-Xiang Sun et al.   HEPATOLOGY

Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

(2012) Alexei V. Salnikov et al.   PLoS One

HIF-2α Suppresses p53 to Enhance the Stemness and Regenerative Potential of Human Embryonic Stem Cells

(2012) Bikul Das et al.   STEM CELLS

Passing the baton: the HIF switch

(2012) Mei Yee Koh et al.   TRENDS IN BIOCHEMICAL SCIENCES

HIF-2α - a mediator of stem cell altruism?

(2012) Eoin P Cummins   Stem Cell Research & Therapy

Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2α induced gene expression

(2011) Tanja Grkovic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion

(2011) M. Y. Koh et al.   CANCER RESEARCH

Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells

(2011) Urszula Florczyk et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Mouse Model of Cholestasis-Associated Cholangiocarcinoma and Transcription Factors Involved in Progression

(2011) Heping Yang et al.   GASTROENTEROLOGY

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

(2011) Aijuan Qu et al.   HEPATOLOGY

Opposing roles for HIF-1  and HIF-2  in the regulation of angiogenesis by mononuclear phagocytes

(2010) T. D. Eubank et al.   BLOOD

Hypoxia inducible factors in cancer stem cells

(2010) J M Heddleston et al.   BRITISH JOURNAL OF CANCER

HIF-1α and HIF-2α correlate with migration and invasion in gastric cancer

(2010) Yanxia Wang et al.   CANCER BIOLOGY & THERAPY

HIF-2  Enhances  -Catenin/TCF-Driven Transcription by Interacting with  -Catenin

(2010) H. Choi et al.   CANCER RESEARCH

Cellular prion protein promotes glucose uptake through the Fyn-HIF-2α-Glut1 pathway to support colorectal cancer cell survival

(2010) Qing-Quan Li et al.   CANCER SCIENCE

Roles of hypoxia-inducible factor-1α (HIF-1α) versus HIF-2α in the survival of hepatocellular tumor spheroids

(2010) Heidi Menrad et al.   HEPATOLOGY

Overexpression of von Hippel–Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice

(2010) Jizhou Wang et al.   JOURNAL OF HEPATOLOGY

Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1a and HIF-2a target genes

(2010) Sang Y Chun et al.   Molecular Cancer

Opposite functions of HIF-α isoforms in VEGF induction by TGF-β1 under non-hypoxic conditions

(2010) K S Chae et al.   ONCOGENE

HIF-2  deletion promotes Kras-driven lung tumor development

(2010) J. Mazumdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Regulation of Angiogenesis by Oxygen and Metabolism

(2009) Peter Fraisl et al.   DEVELOPMENTAL CELL

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor

(2009) Zahid N. Rabbani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factors in stem cells and cancer

(2009) Jolly Mazumdar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment

(2009) K. Burkitt et al.   MOLECULAR CANCER THERAPEUTICS

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

HIF2  inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

(2009) J. A. Bertout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human cancers converge at the HIF-2α oncogenic axis

(2009) Aleksandra Franovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factor-2: effect on radiation sensitivity and differential regulation by an mTOR inhibitor

(2008) Rupal S. Bhatt et al.   BJU INTERNATIONAL

Poorer outcome in stromal HIF-2α- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis

(2008) A H G Cleven et al.   BRITISH JOURNAL OF CANCER

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

HIF-1α and HIF-2α have divergent roles in colon cancer

(2008) Takaaki Imamura et al.   INTERNATIONAL JOURNAL OF CANCER

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice

(2008) E B Rankin et al.   ONCOGENE