Role of Iron in Aging Related Diseases

Hepatic macrophage accumulation with aging: cause for concern?

(2021) Steven A. Bloomer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae

(2021) Sandra Montella-Manuel et al.   BIOCHEMICAL JOURNAL

Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: a case report

(2021) Sohji Nishina et al.   BMC GASTROENTEROLOGY

The Clinical Significance of Iron Overload and Iron Metabolism in Myelodysplastic Syndrome and Acute Myeloid Leukemia

(2021) Sarah Weber et al.   Frontiers in Immunology

Clioquinol Attenuates Pulmonary Fibrosis Through Inactivation of Fibroblasts via Iron Chelation

(2021) Yumeng Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

PPARα agonist fenofibrate attenuates iron-induced liver injury in mice by modulating the Sirt3 and β-catenin signaling

(2021) Ashok Mandala et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effect of iron chelation on anti-pseudomonal activity of doxycycline

(2021) M.E. Faure et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Serum Biomarkers of Iron Status and Risk of Hepatocellular Carcinoma Development in Patients with Nonalcoholic Fatty Liver Disease

(2021) Yi-Chuan Yu et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma

(2020) Md. Khadem Ali et al.   EUROPEAN RESPIRATORY JOURNAL

Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

(2020) Paul R. H. J. Timmers et al.   Nature Communications

The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls

(2019) Camille Petillon et al.   Frontiers in Neuroscience

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

(2019) Uxía Nogueira-Recalde et al.   EBioMedicine

Impact of Autophagy and Aging on Iron Load and Ferritin in Drosophila Brain

(2019) Anne-Claire Jacomin et al.   Frontiers in Cell and Developmental Biology

New insights into the role of iron in inflammation and atherosclerosis

(2019) Anne Cornelissen et al.   EBioMedicine

Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging

(2019) Anna Cozzi et al.   Stem Cell Reports

Tannic acid (TA): A molecular tool for chelating and imaging labile iron

(2018) Isara Phiwchai et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically

(2018) Sonal Agrawal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

(2018) Kapil Chaudhary et al.   Scientific Reports

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications

(2018) Jun-Lin Liu et al.   Frontiers in Neuroscience

Aging results in iron accumulations in the non-human primate choroid of the eye without an associated increase in zinc, copper or sulphur

(2018) M. Ugarte et al.   BIOMETALS

Metformin Affects Heme Function as a Possible Mechanism of Action

(2018) Xiyan Li et al.   G3-Genes Genomes Genetics

Targeting iron metabolism in drug discovery and delivery

(2017) Bart J. Crielaard et al.   NATURE REVIEWS DRUG DISCOVERY

Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis

(2017) Abitha Sukumaran et al.   Scientific Reports

Pulmonary Iron Homeostasis in Hepcidin Knockout Mice

(2017) Jean-Christophe Deschemin et al.   Frontiers in Physiology

Gender difference in type 2 diabetes and the role of body iron stores

(2017) Alex Aregbesola et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease

(2017) Joana Neves et al.   EBioMedicine

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

(2016) Zhu-Ling Guo et al.   Journal of Hematology & Oncology

Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

(2016) Suzanne M Cloonan et al.   NATURE MEDICINE

Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner

(2016) Sven Brandstädt et al.   Aging-US

Iron promotes protein insolubility and aging in C. elegans

(2016) Ida M. Klang et al.   Aging-US

The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

(2015) Lize F D van Vulpen et al.   JOURNAL OF CLINICAL PATHOLOGY

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

(2015) Simon A. James et al.   Chemical Science

HFE Genotyping in Patients with Elevated Serum Iron Indices and Liver Diseases

(2015) Andreia Silva Evangelista et al.   Biomed Research International

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

(2014) K. Mleczko-Sanecka et al.   BLOOD

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

(2014) Yoshihiko Ichikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepcidin knockout mice fed with iron-rich diet develop chronic liver injury and liver fibrosis due to lysosomal iron overload

(2014) Mariia Lunova et al.   JOURNAL OF HEPATOLOGY

Iron-Dependent Regulation of Hepcidin in Hjv−/− Mice: Evidence That Hemojuvelin Is Dispensable for Sensing Body Iron Levels

(2014) Konstantinos Gkouvatsos et al.   PLoS One

Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms

(2014) Sonia Levi et al.   Frontiers in Pharmacology

Iron and Cancer Risk--A Systematic Review and Meta-analysis of the Epidemiological Evidence

(2013) A. Fonseca-Nunes et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cardiac Involvement in Hemochromatosis

(2013) Vinay Gulati et al.   Cardiology in Review

Iron and Diabetes Risk

(2013) Judith A. Simcox et al.   Cell Metabolism

The small molecule, genistein, increases hepcidin expression in human hepatocytes

(2013) Aileen W. Zhen et al.   HEPATOLOGY

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron levels in the human brain: A post-mortem study of anatomical region differences and age-related changes

(2013) Patrícia Ramos et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Iron status in the elderly

(2013) Susan J. Fairweather-Tait et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Multi-Copper Oxidases and Human Iron Metabolism

(2013) Ganna Vashchenko et al.   Nutrients

Increased serum ferritin predicts the development of hypertension among middle-aged men

(2012) Mee Kyoung Kim et al.   AMERICAN JOURNAL OF HYPERTENSION

Aspirin Inhibits Oxidant Stress, Reduces Age-Associated Functional Declines, and Extends Lifespan of Caenorhabditis elegans

(2012) Srinivas Ayyadevara et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular Diagnostic and Pathogenesis of Hereditary Hemochromatosis

(2012) Paulo C. J. L. Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron, Meat and Health

(2011) Catherine Geissler et al.   Nutrients

Iron Homeostasis and the Inflammatory Response

(2010) Marianne Wessling-Resnick   Annual Review of Nutrition

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferroportin disease: A systematic meta-analysis of clinical and molecular findings

(2010) Roman Mayr et al.   JOURNAL OF HEPATOLOGY

Clinically available iron chelators induce neuroprotection in the 6-OHDA model of Parkinson’s disease after peripheral administration

(2010) David T. Dexter et al.   JOURNAL OF NEURAL TRANSMISSION

A Calorie-Restricted Diet Decreases Brain Iron Accumulation and Preserves Motor Performance in Old Rhesus Monkeys

(2010) E. K. Kastman et al.   JOURNAL OF NEUROSCIENCE

Iron Overload Cardiomyopathy

(2010) Pradeep Gujja et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

(2010) R. K. Minor et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Magnetic Resonance Imaging Quantification of Liver Iron

(2010) Claude B. Sirlin et al.   Magnetic Resonance Imaging Clinics of North America

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging

(2010) Jinze Xu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Iron: An emerging factor in colorectal carcinogenesis

(2010) Anita CG Chua   WORLD JOURNAL OF GASTROENTEROLOGY

A prospective study of meat, cooking methods, meat mutagens, heme iron, and lung cancer risks

(2009) Nataša Tasevska et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Integration of Genomic and Genetic Approaches Implicates IREB2 as a COPD Susceptibility Gene

(2009) Dawn L. DeMeo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats

(2009) Edson Lucas Santos et al.   BIOCHEMICAL PHARMACOLOGY

The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase II  in Breast Cancer Cells

(2009) V. A. Rao et al.   CANCER RESEARCH

Age-dependent and gender-specific changes in mouse tissue iron by strain

(2009) Paul Hahn et al.   EXPERIMENTAL GERONTOLOGY

Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties

(2009) Orly Weinreb et al.   Genes and Nutrition

Hereditary hemochromatosis and diabetes mellitus: implications for clinical practice

(2009) Kristina M. Utzschneider et al.   Nature Reviews Endocrinology

Body iron metabolism and pathophysiology of iron overload

(2008) Yutaka Kohgo et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1

(2008) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron-binding and anti-Fenton properties of baicalein and baicalin

(2008) Carlos A. Perez et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Does iron have a role in breast cancer?

(2008) Xi Huang   LANCET ONCOLOGY

Iron Accumulation with Age, Oxidative Stress and Functional Decline

(2008) Jinze Xu et al.   PLoS One