The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study

(2015) L.F.D. van Vulpen et al.   OSTEOARTHRITIS AND CARTILAGE

Hemolysis-induced lethality involves inflammasome activation by heme

(2014) Fabianno F. Dutra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deferasirox limits cartilage damage following haemarthrosis in haemophilic mice

(2014) Goris Roosendaal et al.   THROMBOSIS AND HAEMOSTASIS

VCAM-1 serum levels are associated with arthropathy in hereditary haemochromatosis

(2013) Valerie Nell-Duxneuner et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-1 receptor antagonist in refractory haemochromatosis-related arthritis of the hands

(2013) Augustin Latourte et al.   ANNALS OF THE RHEUMATIC DISEASES

Iron Overload Inhibits Osteoblast Biological Activity Through Oxidative Stress

(2013) Yin-Feng He et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Angiogenesis is increased in advanced haemophilic joint disease and characterised by normal pericyte coverage

(2013) Eva Zetterberg et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Identification and expression of iron regulators in human synovium: evidence for upregulation in haemophilic arthropathy compared to rheumatoid arthritis, osteoarthritis, and healthy controls

(2013) L. Nieuwenhuizen et al.   HAEMOPHILIA

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

(2013) Guangyi Li et al.   ARTHRITIS RESEARCH & THERAPY

Genetic modification of iron metabolism in mice affects the gut microbiota

(2012) Keren Buhnik-Rosenblau et al.   BIOMETALS

A single intra-articular injection with IL-4 plus IL-10 ameliorates blood-induced cartilage degeneration in haemophilic mice

(2012) Monique E. R. van Meegeren et al.   BRITISH JOURNAL OF HAEMATOLOGY

Guidelines for the management of hemophilia

(2012) A. Srivastava et al.   HAEMOPHILIA

Prevalence and Progress of Joint Symptoms in Hereditary Hemochromatosis and Symptomatic Response to Venesection

(2012) Leonard C. Harty et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

RANK-RANKL-OPG in Hemophilic Arthropathy: From Clinical and Imaging Diagnosis to Histopathology

(2012) DANIELA MELCHIORRE et al.   JOURNAL OF RHEUMATOLOGY

Nuclear factor (NF)-κB and its associated pathways are major molecular regulators of blood-induced joint damage in a murine model of hemophilia

(2012) D. Sen et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Modern haemophilia care

(2012) Erik Berntorp et al.   LANCET

Iron Overload in Human Disease

(2012) Robert E. Fleming et al.   NEW ENGLAND JOURNAL OF MEDICINE

Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells

(2012) M. Doyard et al.   OSTEOPOROSIS INTERNATIONAL

Prophylaxis in Children with Hemophilia: Evidence-Based Achievements, Old and New Challenges

(2012) Antonio Coppola et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Haemochromatosis: The bone and the joint

(2011) Pascal Guggenbuhl et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Trends in bleeding patterns during prophylaxis for severe haemophilia: observations from a series of prospective clinical trials

(2011) K. FISCHER et al.   HAEMOPHILIA

Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1  Secretion through the NLRP3 Inflammasome In Vitro

(2011) B. Pazar et al.   JOURNAL OF IMMUNOLOGY

Characteristics of the arthropathy described in hereditary hemochromatosis

(2011) G. J. Carroll et al.   ARTHRITIS CARE & RESEARCH

Synovial tissue hypoxia and inflammation in vivo

(2010) C. T. Ng et al.   ANNALS OF THE RHEUMATIC DISEASES

Hereditary hemochromatosis is characterized by a clinically definable arthropathy that correlates with iron load

(2010) G. J. Carroll et al.   ARTHRITIS AND RHEUMATISM

Musculoskeletal disease burden of hereditary hemochromatosis

(2010) Enijad Sahinbegovic et al.   ARTHRITIS AND RHEUMATISM

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Neoangiogenesis contributes to the development of hemophilic synovitis

(2010) S. S. Acharya et al.   BLOOD

Haemochromatosis as a window into the study of the immunological system: A novel correlation between CD8+ lymphocytes and iron overload

(2010) Graça Porto et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Musculoskeletal Complications of Hereditary Hemochromatosis: A Case-Control Study

(2010) P. RICHETTE et al.   JOURNAL OF RHEUMATOLOGY

Blood-induced joint disease: the pathophysiology of hemophilic arthropathy

(2010) L. A. VALENTINO   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Bone status in a mouse model of genetic hemochromatosis

(2010) P. Guggenbuhl et al.   OSTEOPOROSIS INTERNATIONAL

Increase in type II collagen turnover after iron depletion in patients with hereditary haemochromatosis

(2010) P. Richette et al.   RHEUMATOLOGY

Rare Types of Genetic Hemochromatosis

(2009) Clara Camaschella et al.   ACTA HAEMATOLOGICA

Synovial immunopathology in haemochromatosis arthropathy

(2009) G. R. Heiland et al.   ANNALS OF THE RHEUMATIC DISEASES

Changing patterns of bleeding in patients with severe haemophilia A

(2009) D. STEPHENSEN et al.   HAEMOPHILIA

Prevalence and risk factors associated with decreased bone mineral density in patients with haemophilia

(2009) G. GERSTNER et al.   HAEMOPHILIA

Excess iron inhibits osteoblast metabolism

(2009) Kanako Yamasaki et al.   TOXICOLOGY LETTERS

Physiopathology of haemophilic arthropathy

(2008) F. P. J. G. LAFEBER et al.   HAEMOPHILIA

Iron inhibits hydroxyapatite crystal growth in vitro

(2008) Pascal Guggenbuhl et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Very rapid clearance after a joint bleed in the canine knee cannot prevent adverse effects on cartilage and synovial tissue

(2008) N.W.D. Jansen et al.   OSTEOARTHRITIS AND CARTILAGE

Association between iron overload and osteoporosis in patients with hereditary hemochromatosis

(2008) L. Valenti et al.   OSTEOPOROSIS INTERNATIONAL