Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells

(2013) Wen Guo et al.   AGING CELL

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Hepcidin levels in diabetes mellitus and polycystic ovary syndrome

(2013) A. H. Sam et al.   DIABETIC MEDICINE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes

(2012) Jérémy Huard et al.   FEBS Journal

Inhibition of hepcidin transcription by growth factors

(2012) Julia B. Goodnough et al.   HEPATOLOGY

RASA1 maintains the lymphatic vasculature in a quiescent functional state in mice

(2012) Philip E. Lapinski et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Serum Hepcidin Levels in Subjects with the Metabolic Syndrome: A Population Study

(2012) Nicola Martinelli et al.   PLoS One

Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels

(2011) Irene Pichler et al.   HUMAN MOLECULAR GENETICS

IL-6 Increases MMP-13 Expression and Motility in Human Chondrosarcoma Cells

(2011) Chih-Hsin Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy

(2011) Catherine Espeillac et al.   JOURNAL OF CLINICAL INVESTIGATION

Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma

(2011) Ulrike Maegdefrau et al.   LABORATORY INVESTIGATION

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Molecular basis of iron-loading disorders

(2010) Deepak Darshan et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis

(2010) John D. Ryan et al.   HEPATOLOGY

Factors influencing disease phenotype and penetrance in HFE haemochromatosis

(2010) J. Rochette et al.   HUMAN GENETICS

Anaemia, microcytosis and sirolimus--is iron the missing link?

(2010) S. Sofroniadou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression

(2009) L. Kautz et al.   BLOOD

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

(2009) T. Tanno et al.   BLOOD

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

(2009) K. Mleczko-Sanecka et al.   BLOOD

Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of Hemochromatosis

(2009) Elena Corradini et al.   GASTROENTEROLOGY

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

(2009) G. Ramey et al.   HAEMATOLOGICA

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload

(2009) Daniel F. Wallace et al.   HEPATOLOGY

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

(2009) Guillem Casanovas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

The role of iron in type 2 diabetes in humans

(2008) Swapnil N. Rajpathak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBP 

(2008) J. P. Pinto et al.   BLOOD

Hfe Acts in Hepatocytes to Prevent Hemochromatosis

(2008) Maja Vujić Spasić et al.   Cell Metabolism

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

Molecular mechanisms of hepatocellular carcinoma

(2008) Rajagopal N. Aravalli et al.   HEPATOLOGY

Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity

(2008) Kouichi Miura et al.   HEPATOLOGY

A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells

(2008) Maria Vittoria Verga Falzacappa et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE