Transforming growth factor–β1 in regulatory T cell biology

Defining the role of transforming growth factor β1 in Foxp3+ T regulatory cells

(2021) Garam Choi et al.   IMMUNITY

Autocrine transforming growth factor β1 in regulatory T cell biology—gone but not missed

(2021) Maria Velegraki et al.   IMMUNITY

First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings

(2021) Margaret L. MacMillan et al.   Blood Advances

Novel therapies emerging in oncology to target the TGF-β pathway

(2021) Byung-Gyu Kim et al.   Journal of Hematology & Oncology

A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8

(2021) Robert I. Seed et al.   Science Immunology

Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation

(2021) Joshua M. Moreau et al.   Science Immunology

Pan-cancer single-cell landscape of tumor-infiltrating T cells

(2021) Liangtao Zheng et al.   SCIENCE

Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation

(2021) Alexandra Lainé et al.   Nature Communications

Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β

(2020) Melody G. Campbell et al.   CELL

Transforming growth factor–β in tissue fibrosis

(2020) Nikolaos G. Frangogiannis   JOURNAL OF EXPERIMENTAL MEDICINE

Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β

(2020) Alessandra Metelli et al.   Science Translational Medicine

Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation

(2020) Alessandra Colamatteo et al.   Frontiers in Immunology

Regulatory T Cells Limit Pneumococcus-Induced Exacerbation of Lung Fibrosis in Mice

(2020) Steffi Moyé et al.   JOURNAL OF IMMUNOLOGY

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

(2020) Cristina Ferreira et al.   NATURE IMMUNOLOGY

Large-Scale Generation of Human Allospecific Induced Tregs With Functional Stability for Use in Immunotherapy in Transplantation

(2020) Evelyn Katy Alvarez-Salazar et al.   Frontiers in Immunology

RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity

(2020) Ephraim A. Ansa-Addo et al.   Science Advances

Autocrine TGF-β1 Maintains the Stability of Foxp3+ Regulatory T Cells via IL-12Rβ2 Downregulation

(2020) Garam Choi et al.   Biomolecules

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

(2020) Jacob A. Turner et al.   IMMUNITY

TGF-β1 maintains Foxp3 expression and inhibits glycolysis in natural regulatory T cells via PP2A-mediated suppression of mTOR signaling

(2020) Xuelu Chen et al.   IMMUNOLOGY LETTERS

TGF-β suppresses type 2 immunity to cancer

(2020) Ming Liu et al.   NATURE

Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells

(2020) Shun Li et al.   NATURE

Selective inhibition of TGF-β1 produced by GARP-expressing Tregs overcomes resistance to PD-1/PD-L1 blockade in cancer

(2020) Grégoire de Streel et al.   Nature Communications

Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

(2020) Toshiro Hirai et al.   IMMUNITY

Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies

(2020) Julius Strauss et al.   Journal for ImmunoTherapy of Cancer

Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy

(2019) Shyam S. Bansal et al.   CIRCULATION

Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells

(2019) Veerle Fleskens et al.   Cell Reports

Specificity, versatility, and control of TGF-β family signaling

(2019) Rik Derynck et al.   Science Signaling

c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis

(2019) Christian Neumann et al.   NATURE IMMUNOLOGY

GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon

(2019) Mohammad Salem et al.   CANCER RESEARCH

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity

(2019) Xiang Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses

(2019) Lokesh A. Kalekar et al.   Science Immunology

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

CD226 deficiency on regulatory T cells aggravates renal fibrosis via up‐regulation of Th2 cytokines through miR‐340

(2019) Yang Mu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Homeobox protein Hhex negatively regulates Treg cells by inhibiting Foxp3 expression and function

(2019) Sung Woong Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells

(2019) Liisa Andersen et al.   Cell Reports

A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System

(2018) Yan Qin et al.   CELL

Interleukin 2 promotes hepatic regulatory T cell responses and protects from biliary fibrosis in murine sclerosing cholangitis

(2018) Amy E. Taylor et al.   HEPATOLOGY

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

(2018) Yan Lan et al.   Science Translational Medicine

TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

(2018) Paloma Riquelme et al.   Nature Communications

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets

(2018) Bhavana Priyadharshini et al.   JOURNAL OF IMMUNOLOGY

c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

(2018) Mo Xu et al.   NATURE

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Regulatory T cells in the treatment of disease

(2018) Amir Sharabi et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells

(2018) Stéphanie Liénart et al.   SCIENCE

TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

(2018) Ankur Chakravarthy et al.   Nature Communications

Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses

(2017) Joanne E. Konkel et al.   IMMUNITY

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling

(2017) Ephraim A. Ansa-Addo et al.   JOURNAL OF CLINICAL INVESTIGATION

Force interacts with macromolecular structure in activation of TGF-β

(2017) Xianchi Dong et al.   NATURE

Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8

(2017) Julie Stockis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance

(2017) Eirini Nikolouli et al.   Frontiers in Immunology

Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer

(2016) Alessandra Metelli et al.   CANCER RESEARCH

Control of Foxp3 stability through modulation of TET activity

(2016) Xiaojing Yue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling

(2016) Yan Xing et al.   NATURE IMMUNOLOGY

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Induced Regulatory T Cells: Their Development, Stability, and Applications

(2016) Mitsuhiro Kanamori et al.   TRENDS IN IMMUNOLOGY

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

(2016) Sébastien Viel et al.   Science Signaling

Development of thymic Foxp3+ regulatory T cells: TGF-β matters

(2015) WanJun Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

(2015) John J. Worthington et al.   IMMUNITY

Treg depletion attenuates irradiation-induced pulmonary fibrosis by reducing fibrocyte accumulation, inducing Th17 response, and shifting IFN-γ, IL-12/IL-4, IL-5 balance

(2015) Shanshan Xiong et al.   IMMUNOBIOLOGY

Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients

(2015) Lisa M. Rice et al.   JOURNAL OF CLINICAL INVESTIGATION

GP96 is a GARP chaperone and controls regulatory T cell functions

(2015) Yongliang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

(2015) Julia Cuende et al.   Science Translational Medicine

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

(2014) Xudong Li et al.   CELL

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8

(2014) Justin P. Edwards et al.   JOURNAL OF IMMUNOLOGY

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla

(2014) Mathias Hauri-Hohl et al.   NATURE IMMUNOLOGY

Thymocyte apoptosis drives the intrathymic generation of regulatory T cells

(2014) J. E. Konkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Transforming Growth Factor-β Signaling Controls the Formation and Maintenance of Gut-Resident Memory T Cells by Regulating Migration and Retention

(2013) Nu Zhang et al.   IMMUNITY

Regulation of the Expression of GARP/Latent TGF- 1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation

(2013) J. P. Edwards et al.   JOURNAL OF IMMUNOLOGY

TGF- -Mediated Foxp3 Gene Expression Is Cooperatively Regulated by Stat5, Creb, and AP-1 through CNS2

(2013) C. Ogawa et al.   JOURNAL OF IMMUNOLOGY

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

TGF-β Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function

(2013) Anna Śledzińska et al.   PLOS BIOLOGY

Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing

(2013) Mohammadreza Pakyari et al.   Advances in Wound Care

TGFβ signaling plays a critical role in promoting alternative macrophage activation

(2012) Dapeng Gong et al.   BMC IMMUNOLOGY

Dendritic Cell-Specific Disruption of TGF-  Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity

(2012) R. Ramalingam et al.   JOURNAL OF IMMUNOLOGY

GARP regulates the bioavailability and activation of TGFβ

(2012) Rui Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation

(2012) Nu Zhang et al.   NATURE IMMUNOLOGY

Requirements of transcription factor Smad-dependent and -independent TGF-  signaling to control discrete T-cell functions

(2012) A.-D. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

(2011) John J. Worthington et al.   GASTROENTEROLOGY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

(2011) Ilona Gutcher et al.   IMMUNITY

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

(2011) Elizabeth A. Wohlfert et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-2 Controls the Stability of Foxp3 Expression in TGF- -Induced Foxp3+ T Cells In Vivo

(2011) Q. Chen et al.   JOURNAL OF IMMUNOLOGY

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β

(2011) Joanne E Konkel et al.   NATURE IMMUNOLOGY

All-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus

(2011) Ling Lu et al.   PLoS One

The PDL1-PD1 Axis Converts Human TH1 Cells into Regulatory T Cells

(2011) S. Amarnath et al.   Science Translational Medicine

Positive and Negative Transcriptional Regulation of the Foxp3 Gene is Mediated by Access and Binding of the Smad3 Protein to Enhancer I

(2010) Lili Xu et al.   IMMUNITY

Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

(2010) Weiming Ouyang et al.   IMMUNITY

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Smad2 and Smad3 Are Redundantly Essential for the TGF- -Mediated Regulation of Regulatory T Plasticity and Th1 Development

(2010) T. Takimoto et al.   JOURNAL OF IMMUNOLOGY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance

(2010) Maria Hinterberger et al.   NATURE IMMUNOLOGY

CD4+CD25+Foxp3+ Regulatory T Cells Depletion May Attenuate the Development of Silica-Induced Lung Fibrosis in Mice

(2010) Fangwei Liu et al.   PLoS One

Conversion of Th2 memory cells into Foxp3+ regulatory T cells suppressing Th2-mediated allergic asthma

(2010) B.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg

(2009) Julie Stockis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Alloantigen-specificde novo-induced Foxp3+Treg revertin vivoand do not protect from experimental GVHD

(2009) Christian Koenecke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Generation of mice with a conditional allele for transforming growth factor beta 1 gene

(2009) Mohamad Azhar et al.   GENESIS

Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis

(2009) Mark A.A. Claassen et al.   JOURNAL OF HEPATOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells

(2009) D. Q. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

(2009) R. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control

(2009) G. Wirnsberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

(2008) Jonathan A. Hill et al.   IMMUNITY

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

(2008) Marko Pesu et al.   NATURE

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

(2008) Yongzhong Liu et al.   NATURE IMMUNOLOGY

Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression

(2008) Rui Wang et al.   PLoS One

The stumpy gene is required for mammalian ciliogenesis

(2008) T. Town et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA