TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

(2019) Ricardo J. Miragaia et al.   IMMUNITY

Uhrf1 regulates germinal center B cell expansion and affinity maturation to control viral infection

(2018) Chao Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transcription factor Foxp1 preserves integrity of an active Foxp3 locus in extrathymic Treg cells

(2018) Sayantani Ghosh et al.   Nature Communications

Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb

(2017) Sheila Dias et al.   IMMUNITY

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

(2017) Kazue Someya et al.   INTERNATIONAL IMMUNOLOGY

UHRF1: The key regulator of epigenetics and molecular target for cancer therapeutics

(2017) Harsimran Sidhu et al.   TUMOR BIOLOGY

UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development

(2016) Brandon Kent et al.   DEVELOPMENTAL BIOLOGY

Control of Foxp3 stability through modulation of TET activity

(2016) Xiaojing Yue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

(2016) Yohko Kitagawa et al.   NATURE IMMUNOLOGY

Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes

(2016) Jingyao Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Regulatory T Cells: Their Development, Stability, and Applications

(2016) Mitsuhiro Kanamori et al.   TRENDS IN IMMUNOLOGY

Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis

(2016) Yu Cui et al.   Cell Reports

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

(2015) Weihua Qin et al.   CELL RESEARCH

Whole-genome fingerprint of the DNA methylome during human B cell differentiation

(2015) Marta Kulis et al.   NATURE GENETICS

Epigenetic and transcriptional control of Foxp3+ regulatory T cells

(2015) Jochen Huehn et al.   SEMINARS IN IMMUNOLOGY

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1

(2015) Zhi-Min Zhang et al.   Cell Reports

UHRF1 Is a Sensor for DNA Interstrand Crosslinks and Recruits FANCD2 to Initiate the Fanconi Anemia Pathway

(2015) Chih-Chao Liang et al.   Cell Reports

UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold

(2015) Yanyan Tian et al.   Cell Reports

UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma

(2014) Raksha Mudbhary et al.   CANCER CELL

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

(2014) Xudong Li et al.   CELL

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

Cellular Metabolism on T-Cell Development and Function

(2014) Hui Chen et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

(2014) Yuuki Obata et al.   NATURE IMMUNOLOGY

KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production

(2014) Sudheer K. Pabbisetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

(2014) B. B. Au-Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity

(2014) Yang Sun et al.   Nature Communications

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

(2013) Lan K Nguyen et al.   Cell Communication and Signaling

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

(2013) J.-A. Losman et al.   SCIENCE

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

(2013) Xiaoli Liu et al.   Nature Communications

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

Phosphorylation meets nuclear import: a review

(2012) Jonathan D Nardozzi et al.   Cell Communication and Signaling

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut

(2012) Susan M. Schlenner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability

(2012) H. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity

(2011) Dipica Haribhai et al.   IMMUNITY

IL-2 Controls the Stability of Foxp3 Expression in TGF- -Induced Foxp3+ T Cells In Vivo

(2011) Q. Chen et al.   JOURNAL OF IMMUNOLOGY

UHRF1 phosphorylation by cyclin A2/cyclin-dependent kinase 2 is required for zebrafish embryogenesis

(2011) Jaime Chu et al.   MOLECULAR BIOLOGY OF THE CELL

Quantitative analysis of transient and sustained transforming growth factor-  signaling dynamics

(2011) Z. Zi et al.   Molecular Systems Biology

Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

(2010) Weihua Qin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

(2010) Ye Zheng et al.   NATURE

Regulatory T Cell Suppressive Potency Dictates the Balance between Bacterial Proliferation and Clearance during Persistent Salmonella Infection

(2010) Tanner M. Johanns et al.   PLoS Pathogens

Quantitative DNA Methylation Analysis of FOXP3 as a New Method for Counting Regulatory T Cells in Peripheral Blood and Solid Tissue

(2009) G. Wieczorek et al.   CANCER RESEARCH

The development and function of regulatory T cells

(2009) Creg J. Workman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synergistic effect of TGF-β superfamily members on the induction of Foxp3+ Treg

(2009) Ling Lu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

(2009) Qingguo Ruan et al.   IMMUNITY

Cutting Edge: TCR Stimulation Is Sufficient for Induction of Foxp3 Expression in the Absence of DNA Methyltransferase 1

(2009) S. Z. Josefowicz et al.   JOURNAL OF IMMUNOLOGY

Foxp3 Inhibits RORγt-mediatedIL-17AmRNA Transcription through Direct Interaction with RORγt

(2008) Kenji Ichiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

(2008) Jong Kyong Kim et al.   NUCLEIC ACIDS RESEARCH

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology