Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-10-28
DOI
10.1038/s41467-021-26352-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy
- (2021) Eswari Dodagatta-Marri et al. Cell Reports
- Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β
- (2020) Melody G. Campbell et al. CELL
- αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus
- (2020) J. Nakawesi et al. Mucosal Immunology
- Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells
- (2020) Cristina Ferreira et al. NATURE IMMUNOLOGY
- Transforming Growth Factor-β Signaling in Immunity and Cancer
- (2019) Eduard Batlle et al. IMMUNITY
- Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells
- (2019) Toshiro Hirai et al. IMMUNITY
- Comprehensive Integration of Single-Cell Data
- (2019) Tim Stuart et al. CELL
- A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment
- (2019) Huynh et al. Biomolecules
- TGF-β in T Cell Biology: Implications for Cancer Immunotherapy
- (2018) Amina Dahmani et al. Cancers
- Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors
- (2018) E. Vermeersch et al. CELLULAR IMMUNOLOGY
- Single sample scoring of molecular phenotypes
- (2018) Momeneh Foroutan et al. BMC BIOINFORMATICS
- Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells
- (2018) Stéphanie Liénart et al. SCIENCE
- Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer
- (2016) George Plitas et al. IMMUNITY
- Gut Inflammation in Mice Leads to Reduction in αvβ8 Integrin Expression on CD103+CD11b-Dendritic Cells
- (2016) Dania Chanab et al. Journal of Crohns & Colitis
- Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation
- (2015) John J. Worthington et al. IMMUNITY
- The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship
- (2015) Boris Hinz MATRIX BIOLOGY
- TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data
- (2015) Antonio Colaprico et al. NUCLEIC ACIDS RESEARCH
- Th2 Lymphoproliferative Disorder of LatY136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3+ Regulatory T Cells
- (2014) Y. Wang et al. JOURNAL OF IMMUNOLOGY
- Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8
- (2014) Justin P. Edwards et al. JOURNAL OF IMMUNOLOGY
- TGF-β Activation and Function in Immunity
- (2013) Mark A. Travis et al. Annual Review of Immunology
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8
- (2011) John J. Worthington et al. GASTROENTEROLOGY
- T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-β1 Cytokine
- (2011) Moses K. Donkor et al. IMMUNITY
- The molecular mechanisms of Foxp3 gene regulation
- (2011) Takashi Maruyama et al. SEMINARS IN IMMUNOLOGY
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Mice that lack activity of v 6- and v 8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice
- (2009) P. Aluwihare et al. JOURNAL OF CELL SCIENCE
- iNKT cell development is orchestrated by different branches of TGF-β signaling
- (2009) Jean-Marc Doisne et al. JOURNAL OF EXPERIMENTAL MEDICINE
- GARP (LRRC32) is essential for the surface expression of latent TGF- on platelets and activated FOXP3+ regulatory T cells
- (2009) D. Q. Tran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generation of mice with conditionally activated transforming growth factor beta signaling through the TβRI/ALK5 receptor
- (2008) Laurent Bartholin et al. GENESIS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started