Ferroptosis as a Novel Therapeutic Target for Diabetes and Its Complications

Activation of osteoblast ferroptosis via the METTL3/ASK1‐p38 signaling pathway in high glucose and high fat (HGHF)‐induced diabetic bone loss

(2022) Youfen Lin et al.   FASEB JOURNAL

Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects

(2021) Wen-Qi Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of ferroptosis in the process of diabetes-induced endothelial dysfunction

(2021) Er-Fei Luo et al.   World Journal of Diabetes

Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis

(2021) XinDong Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose

(2021) You Wu et al.   BIOSCIENCE REPORTS

SLC40A1 mediates ferroptosis and cognitive dysfunction in type 1 diabetes

(2021) Lijun Hao et al.   NEUROSCIENCE

Characterization of ferroptosis in kidney tubular cell death under diabetic conditions

(2021) Seonghun Kim et al.   Cell Death & Disease

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

(2021) Xiaomeng Feng et al.   Frontiers in Endocrinology

AGE/RAGE in diabetic kidney disease and ageing kidney

(2021) Xia-Qing Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Mechanisms of Apoptosis Induction and Its Regulation by Fatty Acids in Pancreatic β-Cells

(2021) Jan Šrámek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66Shc

(2021) Yong-Yu Yang et al.   Molecular Medicine Reports

Diabetic ferroptosis plays an important role in triggering on inflammation in diabetic wound

(2021) Shuangwen Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death

(2021) Bastian Krümmel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases

(2021) Xintong Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis

(2021) Qianjin Zhang et al.   LIFE SCIENCES

Salusin‑β participates in high glucose‑induced HK‑2 cell ferroptosis in a Nrf‑2‑dependent manner

(2021) Wen-Juan Wang et al.   Molecular Medicine Reports

The glomerular filtration barrier: a structural target for novel kidney therapies

(2021) Ilse S. Daehn et al.   NATURE REVIEWS DRUG DISCOVERY

Liraglutide Alleviates Cognitive Deficit in db/db Mice: Involvement in Oxidative Stress, Iron Overload, and Ferroptosis

(2021) Ji-Ren An et al.   NEUROCHEMICAL RESEARCH

Ferroptosis in Different Pathological Contexts Seen through the Eyes of Mitochondria

(2021) V. Otasevic et al.   Oxidative Medicine and Cellular Longevity

A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells

(2021) Ola Karmi et al.   Antioxidants

Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs

(2021) Tabitha Jenkins et al.   Antioxidants

A novel identified circular RNA, mmu_mmu_circRNA_0000309 involves in Germacrone-mediated the improvement of diabetic nephropathy through regulating ferroptosis by targeting miR-188-3p/GPX4 signaling axis

(2021) Juan Jin et al.   ANTIOXIDANTS & REDOX SIGNALING

IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

(2021) Hong Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination

(2021) Jingfa Zhang et al.   EXPERIMENTAL CELL RESEARCH

Diabetic kidney disease‐predisposing proinflammatory and profibrotic genes identified by weighted gene co‐expression network analysis (WGCNA)

(2021) Jing Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis

(2021) Zhijun Meng et al.   LIFE SCIENCES

Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells

(2021) Mawieh Hamad et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells

(2021) Xinhao Zhang et al.   TOXICOLOGY

Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways

(2021) Zhiyong Li et al.   Frontiers in Pharmacology

Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis

(2021) Zhaoliang Zhu et al.   Bioengineered

Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury

(2021) Wenyuan Li et al.   Cell Death Discovery

Role of ferritin and oxidative stress index in gestational diabetes mellitus

(2021) Surabhi Gautam et al.   Journal of Diabetes and Metabolic Disorders

Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis

(2020) Xing Zeng et al.   Nutrition & Metabolism

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue

(2020) Riccardo Turchi et al.   Cell Death & Disease

Iron metabolism and type 2 diabetes mellitus: A meta‐analysis and systematic review

(2020) Jingfang Liu et al.   Journal of Diabetes Investigation

Identification of Frataxin as a regulator of ferroptosis

(2020) Jing Du et al.   Redox Biology

Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease

(2020) Pei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

(2020) Lucas Opazo-Ríos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2‐related programmed cell death in an AMPK‐dependent manner

(2020) Chunyan Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SIRT3 deficiency is resistant to autophagy‐dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels

(2020) Dandan Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Germacrone: A potent secondary metabolite with therapeutic potential in metabolic diseases, cancer and viral infections

(2020) Ammara Riaz et al.   CURRENT DRUG METABOLISM

Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death

(2020) Anna Martina Battaglia et al.   Cells

The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis

(2020) Yi Zhou   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Dietary quercetin attenuates depressive-like behaviors by inhibiting astrocyte reactivation in response to stress

(2020) Jiajia Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in Mice

(2020) Huimei Zang et al.   DIABETES

HSF1 functions as a key defender against palmitic acid-induced ferroptosis in cardiomyocytes

(2020) Nian Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Quercetin Alleviates Ferroptosis of Pancreatic β Cells in Type 2 Diabetes

(2020) Dan Li et al.   Nutrients

Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis

(2020) Yasir Abdul et al.   Translational Stroke Research

Oxidative Damage and Antioxidant Defense in Ferroptosis

(2020) Feimei Kuang et al.   Frontiers in Cell and Developmental Biology

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

(2020) Yue Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

(2020) Hongdong Ma et al.   Oxidative Medicine and Cellular Longevity

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Global prevalence of diabetic retinopathy: protocol for a systematic review and meta-analysis

(2019) Riccardo Cheloni et al.   BMJ Open

Socioeconomic status and the association between arsenic exposure and type 2 diabetes

(2019) Stephanie M. Eick et al.   ENVIRONMENTAL RESEARCH

An update on therapies for the treatment of diabetes-induced osteoporosis

(2019) Sahar Mohsin et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Metformin in 2019

(2019) James Flory et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High-density lipoprotein ameliorates palmitic acid-induced lipotoxicity and oxidative dysfunction in H9c2 cardiomyoblast cells via ROS suppression

(2019) Kuen-Ming Wu et al.   Nutrition & Metabolism

New insights into the mechanisms of diabetic complications: role of lipids and lipid metabolism

(2019) Stephanie Eid et al.   DIABETOLOGIA

The multifaceted role of iron in renal health and disease

(2019) Rachel P. L. van Swelm et al.   Nature Reviews Nephrology

Mulberry leaf reduces inflammation and insulin resistance in type 2 diabetic mice by TLRs and insulin Signalling pathway

(2019) Simin Tian et al.   BMC Complementary and Alternative Medicine

Renoprotective effects of sodium-glucose cotransporter-2 inhibitors and underlying mechanisms

(2019) Naoki Kashihara et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

(2019) Wenyuan Li et al.   DNA AND CELL BIOLOGY

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

(2019) Sen Wei et al.   JOURNAL OF HAZARDOUS MATERIALS

NEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer

(2018) Ron Mittler et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis is a lysosomal cell death process

(2018) Huan Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Estimated daily quercetin intake and association with the prevalence of type 2 diabetes mellitus in Chinese adults

(2018) Zhanxin Yao et al.   EUROPEAN JOURNAL OF NUTRITION

The tumor suppressor protein p53 and the ferroptosis network

(2018) Rui Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diabetic Retinopathy: Pathophysiology and Treatments

(2018) Wei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effect of selenium supplementation following oxidative stress mediated by glucose on retinal pigment epithelium

(2018) Raquel González de Vega et al.   Metallomics

Cellular death, reactive oxygen species (ROS) and diabetic complications

(2018) Caroline Maria Oliveira Volpe et al.   Cell Death & Disease

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers

(2018) Géraldine Gentric et al.   Cell Metabolism

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer's Disease Detected in vivo with Magnetic Resonance Imaging

(2018) Erika P. Raven et al.   JOURNAL OF ALZHEIMERS DISEASE

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

(2018) Zheyu Shen et al.   ACS Nano

Modulating impacts of quercetin/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats

(2018) Hebatollah E. Eitah et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A shared comparison of diabetes mellitus and neurodegenerative disorders

(2017) Mahmoud Morsi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Evolution of Voltage-Dependent Anion Channel Function: From Molecular Sieve to Governator to Actuator of Ferroptosis

(2017) John J. Lemasters   Frontiers in Oncology

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

(2016) Maria Grau-Pérez et al.   DIABETES CARE

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

(2016) Diego Martin-Sanchez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Inhibition of Receptor Interacting Protein Kinases Attenuates Cardiomyocyte Hypertrophy Induced by Palmitic Acid

(2016) Mingyue Zhao et al.   Oxidative Medicine and Cellular Longevity

Quercetin Decreases Insulin Resistance in a Polycystic Ovary Syndrome Rat Model by Improving Inflammatory Microenvironment

(2016) Zhenzhi Wang et al.   Reproductive Sciences

Role of the endocannabinoid system in diabetes and diabetic complications

(2015) G Gruden et al.   BRITISH JOURNAL OF PHARMACOLOGY

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Stratified medicine for the use of antidiabetic medication in treatment of type II diabetes and cancer: where do we go from here?

(2015) A. Emami-Riedmaier et al.   JOURNAL OF INTERNAL MEDICINE

HSPB1 as a novel regulator of ferroptotic cancer cell death

(2015) X Sun et al.   ONCOGENE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Palmitate Induces ER Stress and Autophagy in H9c2 Cells: Implications for Apoptosis and Adiponectin Resistance

(2014) Min Park et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus

(2014) Gudrun Leidig-Bruckner et al.   BMC Endocrine Disorders

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells

(2013) G Bardy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Iron restriction prevents diabetic nephropathy in Otsuka Long-Evans Tokushima fatty rat

(2013) Mika Matsumoto et al.   RENAL FAILURE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species

(2012) Peng Jia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Fenofibrate

(2011) Kate McKeage et al.   DRUGS

The global burden of diabetes and its complications: an emerging pandemic

(2010) Dieren Susan van et al.   EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY