Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis

Early Worsening of Diabetic Nephropathy in Type 2 Diabetes After Rapid Improvement in Chronic Severe Hyperglycemia

(2021) Tim Cundy et al.   DIABETES CARE

High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy

(2021) Xiangqin Meng et al.   ACS Nano

A compendium of kinetic modulatory profiles identifies ferroptosis regulators

(2021) Megan Conlon et al.   Nature Chemical Biology

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

(2021) Xiaomeng Feng et al.   Frontiers in Endocrinology

IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes

(2021) Abigail C. Lay et al.   DIABETOLOGIA

Protective Role of the M-Sec–Tunneling Nanotube System in Podocytes

(2021) Federica Barutta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The emerging role of ferroptosis in intestinal disease

(2021) Shu Xu et al.   Cell Death & Disease

EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

(2021) Jasmin I. Maier et al.   Cell Reports

Transcription factors in ferroptotic cell death

(2020) Chongshan Dai et al.   CANCER GENE THERAPY

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanistic insights into the urea-induced denaturation of a non-seleno thiol specific antioxidant human peroxiredoxin 6

(2020) Sana Qausain et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

SIRT3 deficiency is resistant to autophagy‐dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels

(2020) Dandan Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

FOXO3a accumulation and activation accelerate oxidative stress‐induced podocyte injury

(2020) Xiaowen Chen et al.   FASEB JOURNAL

Inhibition of miR-17~92 Cluster Ameliorates High Glucose-Induced Podocyte Damage

(2020) Xiaobao Fan et al.   MEDIATORS OF INFLAMMATION

Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6

(2020) Bhavana Chhunchha et al.   Cells

Down-regulation of SETD6 protects podocyte against high glucose and palmitic acid-induced apoptosis, and mitochondrial dysfunction via activating Nrf2-Keap1 signaling pathway in diabetic nephropathy

(2020) Xiang Wang et al.   JOURNAL OF MOLECULAR HISTOLOGY

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

(2020) Yue Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of PRDX6 as a regulator of ferroptosis

(2019) Bin Lu et al.   ACTA PHARMACOLOGICA SINICA

Protective role of exogenous recombinant peroxiredoxin 6 under ischemia-reperfusion injury of kidney

(2019) R. G. Goncharov et al.   CELL AND TISSUE RESEARCH

Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells

(2019) Bhavana Chhunchha et al.   Cells

Programmed Cell-Death by Ferroptosis: Antioxidants as Mitigators

(2019) Kajarabille et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers

(2019) Eikan Mishima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice

(2019) Chao Zheng et al.   Cell Death & Disease

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

(2019) Wenyuan Li et al.   DNA AND CELL BIOLOGY

MicroRNA-129 and -335 Promote Diabetic Wound Healing by Inhibiting Sp1-Mediated MMP-9 Expression

(2018) Wei Wang et al.   DIABETES

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress

(2018) Bhavana Chhunchha et al.   Aging-US

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms

(2017) Hassan Melhem et al.   Journal of Crohns & Colitis

DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury

(2017) Li Zhang et al.   KIDNEY INTERNATIONAL

Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation

(2017) Bhavana Chhunchha et al.   Cell Death & Disease

Apelin involved in progression of diabetic nephropathy by inhibiting autophagy in podocytes

(2017) Yu Liu et al.   Cell Death & Disease

Peroxiredoxin 6 overexpression attenuates lipopolysaccharide-induced acute kidney injury

(2017) Dong Hun Lee et al.   Oncotarget

Peroxiredoxin 6 expression is inversely correlated with nuclear factor-κB activation during Clonorchis sinensis infestation

(2016) Jhang Ho Pak et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of the Kidney Transcriptome of the Long-Haired Mouse Abrothrix hirta (Rodentia, Sigmodontinae) and Comparison with That of the Olive Mouse A. olivacea

(2015) Lourdes Valdez et al.   PLoS One

Transcription Factor NF-Y Is a Functional Regulator of the Transcription of Core Clock GeneBmal1

(2013) Jun Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB, Sp1 and NF-Y as transcriptional regulators of human SND1 gene

(2012) Sandra Armengol et al.   BIOCHIMIE

Podocytopathy in Diabetes: A Metabolic and Endocrine Disorder

(2011) Ana Diez-Sampedro et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production

(2011) J. Toyonaga et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress

(2011) B Chhunchha et al.   Cell Death & Disease

Peroxiredoxin 6: A Bifunctional Enzyme with Glutathione Peroxidase and Phospholipase A2 Activities

(2010) Aron B. Fisher   ANTIOXIDANTS & REDOX SIGNALING

Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plants

(2010) Sarvajeet Singh Gill et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure

(2009) Eri Kubo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hyperglycemia and mechanical stress: Targeting the renal podocyte

(2009) Barbara Lewko et al.   JOURNAL OF CELLULAR PHYSIOLOGY