Article
Nutrition & Dietetics
Rajiv Rana, Jayakumar Manoharan, Anubhuti Gupta, Dheerendra Gupta, Ahmed Elwakiel, Hamzah Khawaja, Sameen Fatima, Silke Zimmermann, Kunal Singh, Saira Ambreen, Ihsan Gadi, Ronald Biemann, Shihai Jiang, Khurrum Shahzad, Shrey Kohli, Berend Isermann
Summary: Diabetic kidney disease (DKD) is a growing pandemic associated with obesity and diabetes mellitus. DKD is now the leading cause of end-stage renal disease and is linked to increased risk of cardiovascular morbidity and mortality. This study demonstrates that the cytoprotective coagulation protease activated protein C (aPC) reduces mitochondrial ROS generation in tubular cells and mitigates renal sterile inflammation in DKD, supporting the potential therapeutic use of aPC in DKD treatment.
Article
Biochemistry & Molecular Biology
Shuangwen Li, Lisi Zheng, Jun Zhang, Xuejun Liu, Zhongming Wu
Summary: Our research demonstrated the involvement of ferroptosis in the development of DN, and up-regulating Nrf2 with fenofibrate treatment inhibited diabetes-related ferroptosis, delaying the progression of DN. This study provided a new perspective on the development mechanism of DN and offered a new approach to delay the progression of DN.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Endocrinology & Metabolism
Nirmal Verma, Florin Despa
Summary: Chronic kidney disease (CKD) is on the rise globally, especially in individuals with diabetic states. CKD progression is influenced by renal hypoxia and the accumulation of amyloid-forming amylin in the kidney, which is secreted by the pancreas. This accumulation is associated with hypertension, mitochondrial dysfunction, increased production of reactive oxygen species (ROS), and activation of hypoxia signaling in the kidney. This review discusses the potential associations between renal amylin amyloid accumulation, hypertension, and mechanisms of hypoxia-induced kidney dysfunction, including activation of hypoxia-inducible factors (HIFs) and mitochondrial dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Ting-Ting Chang, Chih-Hung Chiang, Ching Chen, Su-Chu Lin, Hsin-Jou Lee, Jaw-Wen Chen
Summary: Hydralazine can protect renal proximal tubular epithelial cells from high glucose insults and prevent renal damage through XO/NADPH oxidase inhibition and Nrf2/HO-1 activation, indicating comprehensive antioxidation and anti-inflammation mechanisms for managing DN.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Bingbing Zhu, Ji Fang, Zhengcai Ju, Ying Chen, Li Wang, Hao Wang, Lina Xing, Aili Cao
Summary: The study demonstrates that Zuogui Wan can improve diabetic nephropathy by inhibiting oxidative stress and podocyte apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hai-Jian Sun, Si-Ping Xiong, Xu Cao, Lei Cao, Meng-Yuan Zhu, Zhi-Yuan Wu, Jin-Song Bian
Summary: Sodium tetrasulfide (Na2S4) treatment can ameliorate diabetic kidney disease by inhibiting inflammation cytokines and reducing oxidative stress, renal fibrosis, and cell apoptosis. Na2S4 acts through sulfhydrating SIRT1 to deactivate p65 NF-kappa B and STAT3 phosphorylation/acetylation, ultimately reducing oxidative stress, inflammation response, and EMT progression in renal tubular epithelial cells.
Review
Engineering, Biomedical
Yuan Xiong, Xiangyu Chu, Tao Yu, Samuel Knoedler, Andreas Schroeter, Li Lu, Kangkang Zha, Ze Lin, Dongsheng Jiang, Yuval Rinkevich, Adriana C. Panayi, Bobin Mi, Guohui Liu, Yanli Zhao
Summary: Diabetic wounds present challenges due to drug resistance, biofilm formation, impaired angiogenesis, and oxidative damage. Reactive oxygen species (ROS) play a crucial role in their pathogenesis. ROS-scavenging nanosystems have shown promise for treating diabetic wounds by reducing inflammation and promoting angiogenesis. However, their therapeutic applicability and efficacy need further investigation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tao Luo, Duo Wang, Lidong Liu, Yan Zhang, Chuangye Han, Ying Xie, Yan Liu, Jingchen Liang, Guanhua Qiu, Hongxue Li, Danke Su, Junjie Liu, Kun Zhang
Summary: A photocleaved O-2-released nanoplatform is developed to convert ROS into RNS for long-lasting antitumor effects, by continuously releasing oxygen and alleviating hypoxia to elevate ROS levels.
Article
Biochemistry & Molecular Biology
Fawzi Khoder-Agha, Thomas Kietzmann
Summary: Reactive oxygen species (ROS) and glycans play crucial roles in cells, both dynamically responding to stressors to maintain cellular balance. The delicate balance of redox potential and glycan biosynthesis vitality are essential for cell survival.
Article
Biochemistry & Molecular Biology
Matthew Reily-Bell, Andrew Bahn, Rajesh Katare
Summary: Research shows that ROS is one of the main causes of diabetic heart disease, and miRNAs play a crucial role in treating the disease. However, since miRNAs have multiple targets and exhibit different functions in different environments, a thorough understanding of their mechanisms is needed for successful application.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Engineering, Biomedical
Chen Shi, Ying Zhang, Guanfu Wu, Zhangyu Zhu, Haiping Zheng, Ximeng Sun, Yongyuan Heng, Shaowei Pan, Haonan Xiu, Jing Zhang, Zhaowei Yin, Ziyi Yu, Bin Liang
Summary: This study developed a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for diabetic wound healing. The hydrogel effectively loaded and released curcumin liposomes and silver nanoparticles (AgNPs), promoting wound healing through ROS scavenging, bactericidal activity, anti-inflammatory effects, and angiogenesis. The hydrogel demonstrated favorable biocompatibility, degradability, and injectivity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Endocrinology & Metabolism
Xiaomeng Feng, Shuo Wang, Zhencheng Sun, Hengbei Dong, Haitian Yu, Mengxiu Huang, Xia Gao
Summary: The study found that ferroptosis aggravated diabetic nephropathy and damaged renal tubules in db/db mice through the HIF-1 alpha/HO-1 pathway.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Xiaowei Zheng, Sampath Narayanan, Cheng Xu, Sofie Eliasson Angelstig, Jacob Grunler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A. Forsberg, Ao Zhang, Kerstin Brismar, Tomas A. Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina
Summary: Excessive production of mitochondrial reactive oxygen species (ROS) in diabetes complications is mainly caused by impaired responses to hypoxia due to the inhibition of hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. Restoring HIF-1 function can attenuate ROS overproduction, protect cells against apoptosis and renal injury in diabetes. These findings suggest that targeting HIF-1 repression could be a potential therapeutic strategy for diabetic complications.
Article
Transplantation
Kelly L. Hudkins, Xianwu Li, Alexander L. Holland, Shreya Swaminathan, Charles E. Alpers
Summary: This study showed that empagliflozin treatment in a mouse model of diabetic nephropathy (DN) improved proteinuria and reversed pathologic alterations, including an increase in podocyte number and density, improvement in podocyte foot process effacement and parietal epithelial cell activation. The study also found that SGLT2 inhibition reduced renal oxidative stress. These findings provide insights into the potential long-term benefits of empagliflozin in humans with DN.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)