Inhibition of Receptor Interacting Protein Kinases Attenuates Cardiomyocyte Hypertrophy Induced by Palmitic Acid

Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion

(2015) Toshinori Aoyagi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury

(2015) Bo Yin et al.   BRAIN RESEARCH

Omega-3-fatty acid adds to the protective effect of flax lignan concentrate in pressure overload-induced myocardial hypertrophy in rats via modulation of oxidative stress and apoptosis

(2015) Arvindkumar E. Ghule et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulation of mTOR Pathway in Exercise-induced Cardiac Hypertrophy

(2015) J. Liao et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

A novel endoplasmic reticulum stress-induced apoptosis model using tunicamycin in primary cultured neonatal rat cardiomyocytes

(2015) MINGZHI SHEN et al.   Molecular Medicine Reports

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis

(2015) A Fauster et al.   Cell Death & Disease

Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells

(2015) S Saveljeva et al.   Cell Death & Disease

Necroptosis Interfaces with MOMP and the MPTP in Mediating Cell Death

(2015) Jason Karch et al.   PLoS One

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

(2014) Xiangnan Zhang et al.   Autophagy

Antioxidant effect of mogrosides against oxidative stress induced by palmitic acid in mouse insulinoma NIT-1 cells

(2014) Q. Xu et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Savings Precede Spending

(2014) Konstantinos Drosatos et al.   CIRCULATION

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet  -Cells via Activation of the Mammalian Target of Rapamycin Pathway

(2014) M. Hatanaka et al.   DIABETES

Multiple pathways are involved in palmitic acid-induced toxicity

(2014) Eun-Jung Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Palmitate Induces ER Stress and Autophagy in H9c2 Cells: Implications for Apoptosis and Adiponectin Resistance

(2014) Min Park et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent

(2014) X. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

(2014) Venkata Prasuja Nakka et al.   MOLECULAR NEUROBIOLOGY

Mesenchymal Stem Cells from Fetal Heart Attenuate Myocardial Injury after Infarction: An In Vivo Serial Pinhole Gated SPECT-CT Study in Rats

(2014) Venkata Naga Srikanth Garikipati et al.   PLoS One

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure

(2014) Kenji Takemoto et al.   FEBS Open Bio

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α

(2013) Yi Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation

(2013) Ryodai Shindo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polyphenon E®, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis

(2013) Federica Rizzi et al.   CARCINOGENESIS

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

(2013) Nufail Khan et al.   CURRENT OPINION IN IMMUNOLOGY

A Novel Mechanism by Which SDF-1  Protects Cardiac Cells From Palmitate-Induced Endoplasmic Reticulum Stress and Apoptosis via CXCR7 and AMPK/p38 MAPK-Mediated Interleukin-6 Generation

(2013) Y. Zhao et al.   DIABETES

Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia–reperfusion injury

(2013) Shizuka Koshinuma et al.   Journal of Anesthesia

Calnexin Silencing in Mouse Neonatal Cardiomyocytes Induces Ca2+Cycling Defects, ER Stress, and Apoptosis

(2013) Nicolas Bousette et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis

(2013) Colleen R. McNamara et al.   PLoS One

Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia–reperfusion in vivo

(2012) Martinus I. F. J. Oerlemans et al.   BASIC RESEARCH IN CARDIOLOGY

The chemical chaperone 4-phenylbutyric acid attenuates pressure-overload cardiac hypertrophy by alleviating endoplasmic reticulum stress

(2012) Chang Sik Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of Autophagy Rescues Palmitic Acid-induced Necroptosis of Endothelial Cells

(2012) Muhammad Jadoon Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A derivative of the CRMP2 binding compound lanthionine ketimine provides neuroprotection in a mouse model of cerebral ischemia

(2012) Shadia E. Nada et al.   NEUROCHEMISTRY INTERNATIONAL

Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia–ischemia

(2012) R. Chavez-Valdez et al.   NEUROSCIENCE

Micro-RNA-195 and -451 Regulate the LKB1/AMPK Signaling Axis by Targeting MO25

(2012) Hao Chen et al.   PLoS One

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

(2012) Kevin Bray et al.   PLoS One

Antiapoptotic and Antiautophagic Effects of Eicosapentaenoic Acid in Cardiac Myoblasts Exposed to Palmitic Acid

(2012) Silvia Cetrullo et al.   Nutrients

Interrelationship Between Cardiac Hypertrophy, Heart Failure, and Chronic Kidney Disease

(2011) Jeffrey G. Dickhout et al.   CIRCULATION RESEARCH

mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy

(2011) Asad Zeidan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Preparation of cells for assessing ultrastructural localization of nanoparticles with transmission electron microscopy

(2010) Amanda M Schrand et al.   Nature Protocols

Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3β/mTOR signaling pathway

(2009) Gabriela Placoná Diniz et al.   BASIC RESEARCH IN CARDIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY