Article
Biochemistry & Molecular Biology
Qingqing Du, Xiaoyun Wu, Kai Ma, Weiwei Liu, Panwen Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima
Summary: This study found that Silibinin protects pancreatic beta-cells from damage induced by high fat and high glucose. In beta-cells, Silibinin can restore mitochondrial function, reduce the activity of the peroxide enzyme system, promote selective mitochondrial autophagy, and effectively inhibit ferroptosis. These findings elucidate the protective mechanism of Silibinin against the damage caused by abnormal glucose and lipid metabolism.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Wenchao Xu, Taotao Sun, Jiaxin Wang, Tao Wang, Shaogang Wang, Jihong Liu, Hao Li
Summary: GPX4 improves erectile function by modulating ferroptosis in diabetes mellitus-induced erectile dysfunction (DMED), providing a potential target in deciphering the molecular mechanism of hyperglycemia-induced ferroptosis.
Review
Medicine, Research & Experimental
Tingting Bao, Xiangyuan Zhang, Weinan Xie, Ying Wang, Xiuyang Li, Cheng Tang, Yingying Yang, Jun Sun, Jiaqi Gao, Tongyue Yu, Linhua Zhao, Xiaolin Tong
Summary: Ferroptosis, a form of cell death, is involved in the regulation of the body's physiological and pathological processes. Recent studies have shown its association with T2DM and its complications, indicating potential therapeutic opportunities through the suppression of ferroptosis. Natural compounds are being explored as potential treatments due to their diverse biological activities and minimal toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Xun Chen, Lejia Zhang, Yi He, Siyuan Huang, Shangwu Chen, Wei Zhao, Dongsheng Yu
Summary: Radiotherapy is commonly used to treat cancers, but radioresistance hinders its efficacy. Recent studies have shown that radiotherapy can induce ferroptotic cancer cell deaths, which offers a potential therapeutic strategy for overcoming radioresistance. m(6)A methylation, a common post-transcriptional modification of mRNA, plays a role in regulating ferroptosis and determining the radiosensitivity of tumor cells. This review summarizes the mechanism and significance of radiotherapy-induced ferroptosis, analyzes the regulatory characteristics of m(6)A modification on ferroptosis, and discusses the possibility of enhancing m(6)A-mediated ferroptosis to improve the efficacy of radiotherapy and overcome radioresistance.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Ling Xie, Bin Fang, Chun Zhang
Summary: The incidence of metabolic diseases such as diabetes, non-alcoholic fatty liver disease, osteoporosis, and atherosclerosis is increasing, posing a significant burden on human health and the economy. Ferroptosis, a recently discovered form of programmed cell death driven by iron-dependent lipid peroxidation, has been shown to contribute to the development of metabolic diseases. This article summarizes the mechanisms and molecular signaling pathways of ferroptosis, discusses its role in metabolic diseases, and analyzes its potential as a promising therapeutic target.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Review
Oncology
Jiahua Chen, Bao Guo, Xiaojing Liu, Jing Zhang, Junhui Zhang, Yuan Fang, Suding Zhu, Bing Wei, Yunxia Cao, Lei Zhan
Summary: This review discusses the role of m(6)A in gynecologic cancers and summarizes the recent advancements in m(6)A modification in gynecologic cancers. It highlights the importance of m(6)A modification in tumor occurrence, metastasis, and treatment, and explores its potential as therapeutic targets and early diagnostic biomarkers.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Yue Sun, Ya-ping Bai, De-guo Wang, Yu-jie Xing, Teng Zhang, Wen Wang, Si-min Zhou, Jin-han Cheng, Wei-wei Chang, Xiang Kong, Xin-ming Yao, Li-qun Guo
Summary: Metformin treatment exerts a protective effect against beta-cell damage in patients with T2DM by modulating ferroptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Wenhao Zhu, Renshan Zhao, Xiaomin Guan, Xu Wang
Summary: This review comprehensively analyzes the impact of m(6)A methylation on Prostate cancer, bladder cancer, and renal cell cancer, as well as the relationship between the expression of relevant regulatory factors and their development and occurrence, providing new insights and approaches for the early clinical diagnosis and targeted therapy of urologic malignancies.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mateusz Kunysz, Olimpia Mora-Janiszewska, Dorota Darmochwal-Kolarz
Summary: This article summarizes the data on epigenetic changes in pregnant women with gestational diabetes in relation to endocrine disrupting chemicals, emphasizing the potential impact of environmental exposure on the development of GDM. There is a suggestion that epigenetic marks could potentially serve as a useful tool for diagnostic, prognostic, and therapeutic purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Lulu Cheng, Siyu Wang, Hailan Tang
Summary: This study utilized a two-sample Mendelian randomization approach to evaluate the causal impact of DM2 on OP, and found that DM2 has a protective effect on OP.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Geriatrics & Gerontology
Zhonghua Gao, Zhuoying Chen, Zhifan Xiong, Xiangjie Liu
Summary: Osteoporosis is a bone metabolic disease characterized by reduced bone mass and deterioration of bone tissue microarchitecture, leading to enhanced skeletal fragility and susceptibility to fracture. Abnormal iron metabolism, specifically iron overload, has been identified as an independent risk factor for osteoporosis. Moreover, the novel form of cell death known as ferroptosis, which involves iron overload and the accumulation of reactive oxygen species (ROS), is believed to play a key role in the occurrence and development of osteoporosis.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuyan Dong, Juxiang Liu, Jing Ma, Jinxing Quan, Yanxia Bao, Yaqiang Cui
Summary: This study found that serum GRB2 concentrations were significantly increased in patients with T2DM combined with CAS, and was linearly correlated with CIMT, suggesting that GRB2 may be involved in the occurrence and development of T2DM with CAS, and can serve as a predictor of whether T2DM is combined with CAS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yan Zhao, Qianqian Gao, Baoxuan Li, Yang Wang, Yue Wang
Summary: This study confirmed the presence of ferroptosis in patients with gestational diabetes mellitus (GDM) and identified key genes associated with ferroptosis in the development of GDM. Traditional Chinese medicine formulas were explored as potential therapeutic drugs for GDM based on ferroptosis, and molecular docking and dynamic simulations were performed to select the best candidates for pharmacological compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Virology
Yu Liu, Kai Li, Yan-Peng Xu, Zhu Zhu, Hui Zhao, Xiao-Feng Li, Qing Ye, Chengqi Yi, Cheng-Feng Qin
Summary: This study profiles the m(6)A modifications on both viral genome RNA and cellular transcripts in a contemporary Asian ZIKV strain, revealing the unique m(6)A distribution in ZIKV-infected cells and highlighting the complexity and importance of m(6)A modification during viral infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Endocrinology & Metabolism
Che Bian, Jing Gao, Yuxia Wang, Jia Li, Zhilin Luan, Heyuan Lu, Huiwen Ren
Summary: The study aimed to detect the expression of serum Sirtuin 6 (SIRT6) and urinary albumin creatinine ratios (UACR) in type 2 diabetes mellitus (T2DM) patients. Results showed that with the aggravation of diabetic status, HbA1c, TNF alpha, HIF1 alpha, and SIRT6 increased significantly. Correlation analysis demonstrated that SIRT6 was significantly positively correlated with glycolipid metabolism and correlated with UACR, TNF alpha, and HIF1 alpha in T2DM patients. Ridge regression analysis showed that SIRT6 was a risk factor for both glycolipid metabolism and urinary protein.
ACTA DIABETOLOGICA
(2021)
Article
Energy & Fuels
Zewen Jin, Xiaoling Zhang, Xiaomin Chen, Zhenjie Du, Lifeng Ping, Zhaoqiang Han, Pengchuang Tao
Summary: Applying biochar to agricultural soils can sequester carbon, improve soil health, and enhance agricultural sustainability. However, our knowledge of the long-term effects of biochar on soil organic carbon mineralization and enzyme activities under field conditions is limited.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Engineering, Civil
Qian Ye, Kaan Ozbay, Fan Zuo, Xiaohong Chen
Summary: This study analyzes the effect of social media on human mobility before and after the COVID-19 outbreak, specifically looking at personal vehicle and public transit use in New York City. The results show a negative correlation between Twitter volume and mobility trends, indicating that social media has an impact on travel decisions. Additionally, the study highlights the different impacts of social media and government policies on vehicular traffic and public transit ridership during the pandemic.
TRANSPORTATION RESEARCH RECORD
(2023)
Article
Agronomy
Shimin Hu, Can Chen, Xiaomin Chen, Feng Jing, Xin Wen
Summary: This study demonstrates that the application of wheat straw biochar can effectively improve the adsorption and accumulation process of Cd2+ in Cd-contaminated soil while inhibiting the migration of Cd into rice, hence reducing the Cd concentration in rice.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2023)
Review
Food Science & Technology
Xiaoyan Chen, Gene Chi Wai Man, Sze Wan Hung, Tao Zhang, Linda Wen Ying Fung, Chun Wai Cheung, Jacqueline Pui Wah Chung, Tin Chiu Li, Chi Chiu Wang
Summary: Endometriosis, a chronic disorder affecting many women, is currently difficult to treat effectively. However, recent studies have shown that green tea, with its bioactive component EGCG, may have potential therapeutic effects on endometriosis by inhibiting various molecular and cellular mechanisms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Engineering, Chemical
Kian Siang Lim, Benu Adhikari, Jie Xiao, Xiao Dong Chen, Cordelia Selomulya, Meng Wai Woo
Summary: This study modified a theoretical framework based on reference-component centered coordinates to enable the prediction of simultaneous absorption and evaporation of droplets consisting of two volatiles. Experimental validation showed that the model reasonably predicted the mass profiles for droplet evaporation but over-predicted in the case of simultaneous absorption and evaporation of droplet.
Article
Environmental Sciences
Xiaohong Chen, Wenyang Deng, Luwei Miao, Ming Gao, Tianqi Ao, Wenqing Chen, Tetsuro Ueyama, Qizhou Dai
Summary: In this study, carbon electrode materials were modified to improve sulfate selectivity in capacitive deionization (CDI), resulting in increased adsorption capacity. The surface of the modified carbon material also displayed improved electrochemical properties and better capacitance. These findings suggest the potential for selective sulfate adsorption in practical applications.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Engineering, Civil
Xiaohong Chen, Tianhao Li, Quan Yuan
Summary: This paper examines the travel behaviors and preferences of Generation Z using the latest data. The results indicate that Generation Z tends to choose environmentally friendly mode of transportation in response to changes in the built environment, showing their potential to support sustainable transportation.
Article
Nanoscience & Nanotechnology
Dan Zhao, Xiaoyu Huang, Yanan Tian, Jianhua Zou, Fu Wang, Xiaoyuan Chen
Summary: Ferroptosis is a new type of programmed cell death that plays a crucial role in tumor inhibition. This study introduces a facile fluorescence imaging-incorporated transcriptome strategy to visualize and explore the mechanism of GSH depletion-enhanced ferroptosis. The results demonstrate that TfRA-AuNCs, a multifunctional nanoplatform, can enhance the ferroptosis effect in 4T1 cells and regulate the expression change of ferroptosis-related genes. In vivo results confirm the tumor inhibition effect and long-term biocompatibility after TfRA-AuNC treatment. This study provides new insights into the mechanistic study of nanoagent-induced ferroptosis in tumor treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Chenchen Zhao, Yuanwei Pan, Guocan Yu, Xing-Zhong Zhao, Xiaoyuan Chen, Lang Rao
Summary: The high stability and binding specificity of antibodies make them widely applicable in various diseases. However, there are limitations to traditional antibody-based therapeutics. Recent advances in cell membrane nanotechnology have led to the development of vesicular-antibody-based therapeutics, which offer new possibilities for disease treatment.
ADVANCED MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hoda S. Ismail, Parveez Ahamed Abdul Azees, Hanzhou Wang, Ashraf I. Ali, Rabab El Mehesen, Salah H. Mahmoud, Xiao-Dong Chen, Chih-Ko Yeh, Franklin Garcia-Godoy
Summary: This study compared the adhesion of periodontopathic bacteria to four restorative materials used for deep margin elevation. The findings showed that the tested flowable bulk fill exhibited better performance in terms of periodontopathic bacterial adhesion.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2023)
Article
Food Science & Technology
Xiaohong Yu, Bingye Gong, Mengyue Li, Wei Li, Xiaodong Chen
Summary: Wheat bran extracts (WBE), consisting primarily of feruloyl oligosaccharides (FOs), have been approved by the FDA for use in microcapsules made with octenyl succinate anhydride-modified starch (OSA-starch) as a protective wall material for beta-carotene (BC) against oxidation. The retention and antioxidant properties of the microcapsules were studied in vivo and in vitro, and it was found that these characteristics were dependent on the amount of WBE in the wall material. In mouse serum and liver, the in vivo antioxidant properties were regulated positively at a dosage similar to that found in wheat grain, but became imbalanced at higher dosages. These findings demonstrate that WBE is a beneficial component for improving the antioxidant environment during storage and consumption, providing a theoretical basis for its industrial application in microcapsules.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Lujie Liu, Yuanwei Pan, Chenchen Zhao, Peng Huang, Xiaoyuan Chen, Lang Rao
Summary: Immune checkpoint blockade (ICB) therapy has made significant advancements in cancer treatment, but limited response rates and systemic toxicity hinder its clinical outcomes. Biomaterials have been developed to enhance ICB therapy by increasing tumor antigenicity, reversing immunosuppressive microenvironment, amplifying antitumor immune response, and improving targeted delivery of checkpoint inhibitors. This review discusses current design strategies for biomaterials, their applications in immune modulation and targeted delivery of checkpoint inhibitors for effective ICB therapy, as well as the challenges and future prospects in this field. It is anticipated that this review will contribute to the development of emerging biomaterials for ICB therapy and the advancement of its clinical application.
Article
Computer Science, Artificial Intelligence
Ying-Ming Wang, Shi-Fan He, Diego Garcia Zamora, Xiao-Hong Pan, Luis Martinez
Summary: This paper proposes a Large-Scale Group Decision-Making method to select the best location for charging stations. The method uses HFLTS and ELICIT model to improve the elicitation process and introduces a TWD-CRP method to improve the group's agreement.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Computer Science, Artificial Intelligence
Zi-Xin Zhang, Liang Wang, Ying-Ming Wang, Luis Martinez
Summary: This study proposes a novel alpha level sets based fuzzy DEMATEL method to handle fuzzy information and considers experts' hesitation under uncertain and fuzzy environment. The proposed method improves the existing fuzzy DEMATEL studies and enriches the theoretical studies of fuzzy DEMATEL.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Engineering, Industrial
Xiaohong Chen, Tianhu Deng, Zuo-Jun Max Shen, Yi Yu
Summary: This article introduces the mission of the Institute of Industrial and Systems Engineers (IISE) and the problems it faces. It identifies three major bottlenecks that limit the industrial implementation of research outcomes and proposes potential solutions, highlighting the importance of data-driven decision methods.