Roles of NRF2 in Fibrotic Diseases: From Mechanisms to Therapeutic Approaches

Impact of Advanced Glycation End products (AGEs) and its receptor (RAGE) on cancer metabolic signaling pathways and its progression

(2022) Yadav Sangeeta Muthyalaiah et al.   GLYCOCONJUGATE JOURNAL

Maresin-1 and Inflammatory Disease

(2022) Natsuko Saito-Sasaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nrf2/ARE axis signalling in hepatocyte cellular death

(2022) Bayan Y. Ghanim et al.   MOLECULAR BIOLOGY REPORTS

The Molecular Mechanisms of Intestinal Inflammation and Fibrosis in Crohn’s Disease

(2022) Yuki Hayashi et al.   Frontiers in Physiology

Gut Microbiota, Macrophages and Diet: An Intriguing New Triangle in Intestinal Fibrosis

(2022) Asma Amamou et al.   Microorganisms

Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling

(2021) Li-Fei Luo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

(2021) Yuta Horie et al.   Communications Biology

Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy

(2021) Saikat Dewanjee et al.   AGEING RESEARCH REVIEWS

The Good and Bad of Nrf2: An Update in Cancer and New Perspectives in COVID-19

(2021) Sonia Emanuele et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Update on the Role of Nrf2 in Respiratory Disease: Molecular Mechanisms and Therapeutic Approaches

(2021) Jooyeon Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intestinal stricture in Crohn's disease: A 2020 update

(2021) Xiao Xuan Lin et al.   Journal of Digestive Diseases

Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma

(2021) Fengzhi Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Therapeutic Targeting of Nrf2 Signaling by Maggot Extracts Ameliorates Inflammation-Associated Intestinal Fibrosis in Chronic DSS-Induced Colitis

(2021) Rong Wang et al.   Frontiers in Immunology

NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch

(2021) Séan M. O’Cathail et al.   Antioxidants

Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages

(2021) Wei Yu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2/Keap1/ARE signaling: Towards specific regulation

(2021) Alexey V. Ulasov et al.   LIFE SCIENCES

Assessment of Protection Offered By the NRF2 Pathway Against Hyperoxia-Induced Acute Lung Injury in NRF2 Knockout Rats

(2021) Said H. Audi et al.   SHOCK

Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota

(2021) Xinling Song et al.   Food & Function

Effects of Puerarin on the Prevention and Treatment of Cardiovascular Diseases

(2021) Yan-Xi Zhou et al.   Frontiers in Pharmacology

Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches – Pulmonary Disease/Asthma

(2021) Camille Audousset et al.   Frontiers in Physiology

Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress

(2021) Bashayer R. Al-Mubarak et al.   Redox Biology

Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation

(2021) María José Rodríguez et al.   Cells

Tanshinone IIA attenuates silica-induced pulmonary fibrosis via Nrf2-mediated inhibition of EMT and TGF-β1/Smad signaling

(2020) Feifei Feng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Oxidative Stress-Responsive MicroRNAs in Heart Injury

(2020) Branislav Kura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of glutaminase to reverse fibrosis in iatrogenic laryngotracheal stenosis

(2020) Hsiu‐Wen Tsai et al.   LARYNGOSCOPE

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

Nrf2 deficiency aggravates PM2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder

(2020) Chenxu Ge et al.   Aging-US

NRF2 as a regulator of cell metabolism and inflammation in cancer

(2020) Feng He et al.   CARCINOGENESIS

Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachloride-induced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses

(2020) Hang Lyu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nonalcoholic Steatohepatitis

(2020) Adam C. Sheka et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dihydroquercetin protects against renal fibrosis by activating the Nrf2 pathway

(2020) Wei Wang et al.   PHYTOMEDICINE

AGER1 downregulation associates with fibrosis in nonalcoholic steatohepatitis and type 2 diabetes

(2020) Ali Dehnad et al.   JOURNAL OF CLINICAL INVESTIGATION

Mangiferin activates Nrf2 to attenuate cardiac fibrosis via redistributing glutaminolysis-derived glutamate

(2020) Junna Song et al.   PHARMACOLOGICAL RESEARCH

The Dark Side of Nrf2 in the Heart

(2020) Huimei Zang et al.   Frontiers in Physiology

Peroxiredoxin-1 ameliorates pressure overload-induced cardiac hypertrophy and fibrosis

(2020) Chaoliang Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Activating AMP‐activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection from Nonalcoholic Fatty Liver Disease in Mice

(2020) Qian Lin et al.   HEPATOLOGY

The Role of the Nrf2 Signaling in Obesity and Insulin Resistance

(2020) Shiri Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The protective effect of Lactobacillus versus 5-aminosalicylic acid in ulcerative colitis model by modulation of gut microbiota and Nrf2/Ho-1 pathway

(2020) Ahmed M. El-Baz et al.   LIFE SCIENCES

Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases

(2020) Yu-Qing Tan et al.   Drug Design Development and Therapy

Roles of Nrf2 in Liver Diseases: Molecular, Pharmacological, and Epigenetic Aspects

(2020) Marina Galicia-Moreno et al.   Antioxidants

Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway

(2020) Kai Chen et al.   CIRCULATION RESEARCH

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

(2020) Nobuaki Takahashi et al.   MOLECULAR CELL

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Induction of HO-1 by 5, 8-Dihydroxy-4 ′ ,7-Dimethoxyflavone via Activation of ROS/p38 MAPK/Nrf2 Attenuates Thrombin-Induced Connective Tissue Growth Factor Expression in Human Cardiac Fibroblasts

(2020) Chien-Chung Yang et al.   Oxidative Medicine and Cellular Longevity

NRF2 in Cardiovascular Diseases: a Ray of Hope!

(2020) Ruju Vashi et al.   Journal of Cardiovascular Translational Research

The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis

(2020) Pengfei Liu et al.   Redox Biology

Therapeutic Effects of Specialized Pro-Resolving Lipids Mediators on Cardiac Fibrosis via NRF2 Activation

(2020) Gyeoung Jin Kang et al.   Antioxidants

The Role of Nrf2 in Liver Disease: Novel Molecular Mechanisms and Therapeutic Approaches

(2019) Dongwei Xu et al.   Frontiers in Pharmacology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

The Molecular Mechanism of Transforming Growth Factor-β Signaling for Intestinal Fibrosis: A Mini-Review

(2019) Sun-Mi Yun et al.   Frontiers in Pharmacology

Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFβ1/Smad2/3 signaling axis

(2019) Rui-Rui Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Challenges in the Pathophysiology, Diagnosis and Management of Intestinal Fibrosis in Inflammatory Bowel Disease

(2019) Geert D’Haens et al.   GASTROENTEROLOGY

Fusobacterium nucleatum Aggravates the Progression of Colitis by Regulating M1 Macrophage Polarization via AKT2 Pathway

(2019) Le Liu et al.   Frontiers in Immunology

Piceatannol alleviates inflammation and oxidative stress via modulation of the Nrf2/HO-1 and NF-κB pathways in diabetic cardiomyopathy

(2019) Hao Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Can Nrf2 Modulate the Development of Intestinal Fibrosis and Cancer in Inflammatory Bowel Disease?

(2019) Simona Pompili et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Free radicals, antioxidants, nuclear factor‐E2‐related factor‐2 and liver damage

(2019) Erika Ramos‐Tovar et al.   JOURNAL OF APPLIED TOXICOLOGY

GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition

(2019) Minglei Lu et al.   Redox Biology

Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells

(2019) Bhavana Chhunchha et al.   Cells

GSTA3 regulates TGF-β1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K–Keap1/Nrf2 pathway

(2019) Yun Xiao et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast growth factors

(2019) Xuran Chu et al.   Frontiers of Medicine

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model

(2018) Shoji Yamada et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Extracellular matrix remodeling and cardiac fibrosis

(2018) Li Li et al.   MATRIX BIOLOGY

Idiopathic Pulmonary Fibrosis

(2018) David J. Lederer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protection by dimethyl fumarate against diabetic cardiomyopathy in type 1 diabetic mice likely via activation of nuclear factor erythroid-2 related factor 2

(2018) Xinyue Hu et al.   TOXICOLOGY LETTERS

Nrf2 antioxidant pathway suppresses Numb-mediated epithelial–mesenchymal transition during pulmonary fibrosis

(2018) Zhihui Zhang et al.   Cell Death & Disease

Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats

(2018) Shao-Ai Cai et al.   Frontiers in Pharmacology

Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

(2018) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Raf kinase inhibitor protein mediates myocardial fibrosis under conditions of enhanced myocardial oxidative stress

(2018) Andrey Kazakov et al.   BASIC RESEARCH IN CARDIOLOGY

Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling

(2018) Guoliang Zhang et al.   Scientific Reports

Modulating ROS to overcome multidrug resistance in cancer

(2018) Qingbin Cui et al.   DRUG RESISTANCE UPDATES

Downregulation of HMGB1 is required for the protective role of Nrf2 in EMT-mediated PF

(2018) Jiao Qu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease

(2018) Sara Lovisa et al.   Journal of Crohns & Colitis

The Biological Role of Klotho Protein in the Development of Cardiovascular Diseases

(2018) Agnieszka Olejnik et al.   Biomed Research International

Nrf2 induces lipocyte phenotype via a SOCS3-dependent negative feedback loop on JAK2/STAT3 signaling in hepatic stellate cells

(2017) Chunfeng Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

(2017) Shasha Tao et al.   MOLECULAR AND CELLULAR BIOLOGY

Sulforaphane prevents bleomycin-induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2-related factor-2 activation

(2017) Bingdi Yan et al.   Molecular Medicine Reports

Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction

(2017) Weiwei Kong et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium

(2017) Yuan Liu et al.   BMC Pulmonary Medicine

TGFβ1 regulates Scleraxis expression in primary cardiac myofibroblasts by a Smad-independent mechanism

(2016) Matthew R. Zeglinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oral pirfenidone protects against fibrosis by inhibiting fibroblast proliferation and TGF-β signaling in a murine colitis model

(2016) Guanwei Li et al.   BIOCHEMICAL PHARMACOLOGY

The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype

(2016) Rushita A. Bagchi et al.   BMC BIOLOGY

Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial–mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis

(2016) Miki Yamaguchi et al.   LABORATORY INVESTIGATION

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

(2016) Meng-Chen Lu et al.   MEDICINAL RESEARCH REVIEWS

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance

(2016) A. L. Furfaro et al.   Oxidative Medicine and Cellular Longevity

Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFβ signaling

(2016) Tian Qin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

(2016) Chong-Yang Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Keap1 hypomorphism protects against ischemic and obstructive kidney disease

(2016) Roderick J. Tan et al.   Scientific Reports

Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis

(2016) Wencheng Zhou et al.   Scientific Reports

Cellular and Molecular Mediators of Intestinal Fibrosis

(2015) Ian C. Lawrance et al.   Journal of Crohns & Colitis

Involvement of Kruppel-like factor 9 in bleomycin-induced pulmonary toxicity

(2015) YUE GU et al.   Molecular Medicine Reports

Metallothionein deletion exacerbates intermittent hypoxia-induced renal injury in mice

(2015) Hao Wu et al.   TOXICOLOGY LETTERS

Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms

(2014) Si Qin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Monitoring Keap1–Nrf2 interactions in single live cells

(2014) Liam Baird et al.   BIOTECHNOLOGY ADVANCES

MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis

(2014) Jing-Jing Yang et al.   CELLULAR SIGNALLING

Nrf2 Amplifies Oxidative Stress via Induction of Klf9

(2014) Shoshanna N. Zucker et al.   MOLECULAR CELL

Activation of the Nrf2-ARE Pathway in Hepatocytes Protects Against Steatosis in Nutritionally Induced Non-alcoholic Steatohepatitis in Mice

(2014) Lung-Yi Lee et al.   TOXICOLOGICAL SCIENCES

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of Nrf2 in chronic liver disease

(2014) Wei Tang   WORLD JOURNAL OF GASTROENTEROLOGY

RXR  Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

(2013) H. Wang et al.   CANCER RESEARCH

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis

(2013) Ulrike A. Köhler et al.   HEPATOLOGY

The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review

(2013) Xiuping Chen et al.   MEDICINAL RESEARCH REVIEWS

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy

(2013) Mohammad A. Aminzadeh et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Nuclear Factor Erythroid 2-Related Factor 2 Nuclear Translocation Induces Myofibroblastic Dedifferentiation in Idiopathic Pulmonary Fibrosis

(2012) Elise Artaud-Macari et al.   ANTIOXIDANTS & REDOX SIGNALING

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression

(2012) Jong Hun Lee et al.   PHARMACOLOGY & THERAPEUTICS

Dimethylfumarate Attenuates Renal Fibrosis via NF-E2-Related Factor 2-Mediated Inhibition of Transforming Growth Factor-β/Smad Signaling

(2012) Chang Joo Oh et al.   PLoS One

Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia

(2010) WITOLD MAZUR et al.   APMIS

Small molecule modulators of antioxidant response pathway

(2010) Wooyoung Hur et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fractionation, partial characterization and bioactivity of water-soluble polysaccharides and polysaccharide–protein complexes from Pleurotus geesteranus

(2010) Mei Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Maggot secretions suppress pro-inflammatory responses of human monocytes through elevation of cyclic AMP

(2009) M. J. A. van der Plas et al.   DIABETOLOGIA