Article
Nutrition & Dietetics
Min Guo, Dehai Xing, Jin Wang, Ying Zhang, Zhuoyu Li, Xiangying Jiao
Summary: Ulcerative colitis (UC) is a growing burden globally, especially in developing countries. This study investigated the effect of N. commune polysaccharides on acute colitis in mice induced by DSS and its role in mediating the gut microbiota. The results showed that N. commune polysaccharides enhanced the intestinal mucosal barrier and exhibited prebiotic-like functions, suggesting its potential as an alternative or complementary treatment for UC.
Article
Microbiology
Orazio Palmieri, Stefano Castellana, Anna Latiano, Tiziana Latiano, Annamaria Gentile, Anna Panza, Marianna Nardella, Davide Ciardiello, Tiziana Pia Latiano, Giuseppe Corritore, Tommaso Mazza, Francesco Perri, Giuseppe Biscaglia
Summary: An increasing amount of evidence suggests the important role of gut microbiota in the development of colorectal cancer. This study analyzed the microbial communities in normal and neoplastic colonic mucosa using NGS and metagenomics analysis tools. The findings revealed weak differences in microbial diversity between CRC and control groups, with an increasing trend of Rikenellaceae, Pseudomonas, and Fusobacterium in CRC. Fusobacterium nucleatum was found to be significantly enriched in all tissues of subjects with synchronous colorectal neoplasia.
Article
Food Science & Technology
Jiao Yu, Junwei Zhao, Huiqun Xie, Ming Cai, Liang Yao, Jinmiao Li, Lan Han, Weidong Chen, Nianjun Yu, Daiyin Peng
Summary: The therapeutic effect of Dendrobium huoshanense polysaccharides (DHP) on ulcerative colitis (UC) is confirmed in this study. Through metabolomics and gut flora analysis, it was found that DHP alleviates UC symptoms by improving colonic mucosal barrier function, reducing inflammation, and modulating the composition of gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Gastroenterology & Hepatology
Le Liu, Liping Liang, Chenghai Yang, Youlian Zhou, Ye Chen
Summary: The study demonstrated that Fusobacterium nucleatum-derived extracellular vesicles induce epithelial cell death and gut barrier disruption in ulcerative colitis, potentially through the activation of receptor-interacting protein kinase 1 (RIPK1). These findings provide insights for further investigation of the disease.
Article
Gastroenterology & Hepatology
Yuan Cao, Jifeng Wang, Weiliang Hou, Yanqiang Ding, Yefei Zhu, Jiayi Zheng, Qiongyi Huang, Zhan Cao, Ruting Xie, Qing Wei, Huanlong Qin
Summary: The gut microbiome is linked to the occurrence and development of colorectal cancer (CRC), and specific features of expressed T cell receptor (TCR) beta repertoires in CRC patients were identified. The relative abundance of certain microorganisms was consistently elevated in CRC patients compared to healthy individuals. The correlation between somatic mutations, TCR clonality, and microbial biomarkers in CRC was investigated, leading to the construction of a classifier for clinical detection of CRC based on the microbiome and TCR repertoires.
Article
Pharmacology & Pharmacy
Heng Li, Yao Zhang, Moting Liu, Chen Fan, Chunlan Feng, Qiukai Lu, Caigui Xiang, Huimin Lu, Xiaoqian Yang, Bing Wu, Duowu Zou, Wei Tang
Summary: Inhibition of PDE4 has been found to be an effective strategy for treating chronic ulcerative colitis (UC) by modulating the cAMP pathway and improving clinical symptoms. This study introduces apremilast as a PDE4 inhibitor and demonstrates its therapeutic capacity in a murine model of chronic UC. It shows that apremilast can restore mucosal homeostasis and improve intestinal barrier function, as well as regulate gut microbiota and antimicrobial responses.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Nutrition & Dietetics
Youlian Zhou, Yan He, Le Liu, Wanyan Zhou, Pu Wang, Han Hu, Yuqiang Nie, Ye Chen
Summary: The study revealed differences in gut microbiota between Chinese and Western populations, as well as distinct microbial characteristics in UC and cCD patients in China. Gardnerella and Fusobacterium were identified as potential biomarkers for distinguishing between UC and cCD, demonstrating an important association between IBD affected bowel region and gut microbiota.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Song Yu, Haixiang Guo, Zhonghao Ji, Yi Zheng, Bingbing Wang, Qingqing Chen, Hongyu Tang, Bao Yuan
Summary: Sea cucumber peptide (SCP) can protect against colitis by modulating the intestinal microbiota composition and the intestinal barrier, as well as inhibiting the polarization of M1 macrophages.
Article
Agriculture, Multidisciplinary
Biao Yu, Min Wang, Bo Teng, Suresh Veeraperumal, Peter Chi-Keung Cheung, Saiyi Zhong, Kit-Leong Cheong
Summary: The protective effect of degraded polysaccharides from Porphyra haitanensis (PHP-D) on the damaged colonic mucosal barrier in ulcerative colitis was investigated in a mouse model. PHP-D treatment reduced the severity of ulcerative colitis and affected the diversity of gut microbiota, increasing the levels of beneficial bacterial species and short-chain fatty acids. PHP-D also restored mucus thickness and improved the expression of tight junction proteins, enhancing the colonic mucosal barrier. These findings suggest that P. haitanensis has great potential as a natural product for the management of ulcerative colitis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Wuqi Yang, Daoyuan Ren, Hongjun Shao, Xiangnan Zhang, Ting Li, Li Zhang, Lei Liu, Yan Zhao, Pengfei Niu, Xingbin Yang
Summary: Fu brick tea theabrownin (FBTB), produced by oxidative polymerization of tea polyphenols, can alleviate various diseases. This study explored the potential of FBTB in treating ulcerative colitis (UC) using a DSS-induced chronic UC mouse model. FBTB effectively reduced colonic damage and inflammation, improved colonic antioxidant capacity, and corrected the disrupted gut microbiota. FBTB elevated microbial tryptophan metabolites by promoting Lactobacillus growth and activated aromatic hydrocarbon receptors (AhRs) to repair the intestinal barrier. These findings demonstrate that FBTB alleviates UC by targeting the gut microbiota and the AhR pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jianling Mo, Jingdan Ni, Ming Zhang, Yang Xu, Yuting Li, Naymul Karim, Wei Chen
Summary: This study first demonstrated the protective effect of mulberry anthocyanins (MAS) on colitis and found that MAS alleviated colitis by maintaining the intestinal barrier, modulating inflammatory cytokines, and improving the microbial community.
Article
Immunology
Jing Yang, Xin Guan, Simeng He, Lixiu Ge, Qiaoying Gao, Xiaoyang Wu
Summary: The study investigates the protective influence of FTY720 on inflammation in a DSS-induced colitis model. The results demonstrate that FTY720 improves the aberrant immune response by trapping T cells and inhibiting the polarization of M1 macrophages in colitis mice. Additionally, the depletion of CCR2 does not affect the protective effect of FTY720 on colonic injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Lijun Hu, Yan Liu, Xuehua Kong, Rui Wu, Qi Peng, Yan Zhang, Lan Zhou, Liang Duan
Summary: The research found that Fusobacterium nucleatum infection is closely associated with the development of colorectal cancer, primarily by promoting the polarization of M2 macrophages to exacerbate tumor malignancy. S100A9 is a key signaling molecule that regulates the activation of M2 macrophages. Targeting the TLR4/NF-kappa B/S100A9 cascade may serve as a promising therapeutic strategy for Fusobacterium nucleatum-associated colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Baixi Zhang, Xinwen Huang, Lijuan Niu, Xuemei Chen, Bo Hu, Xiaoshu Tang
Summary: This study found that Lonicera caerulea pomace (LCP)-supplemented diets can alleviate the symptoms of Dextran Sulfate Sodium (DSS)-induced colitis and exert effects through multiple mechanisms, including anti-inflammation, intestinal barrier repair, and modulation of gut microbiota composition. This suggests the potential importance of LCP in promoting intestinal health.
Article
Neurosciences
Caixia Yan, Qilin Diao, Yuxi Zhao, Cheng Zhang, Xiaoya He, Ruijie Huang, Yan Li
Summary: This study found that oral infection with F. nucleatum may contribute to abnormalities in cognitive ability and pathological changes in the brain of AD-like rats, which may be related to abnormal gut microbiota composition.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Jun Deng, Lishan Zeng, Xueying Lai, Jing Li, Le Liu, Qianyun Lin, Ye Chen
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Microbiology
Youlian Zhou, Zhenjiang Zech Xu, Yan He, Yunsheng Yang, Le Liu, Qianyun Lin, Yugiang Nie, Mingsong Li, Fachao Zhi, Side Liu, Amnon Amir, Antonio Gonzalez, Anupriya Tripathi, Minhu Chen, Gary D. Wu, Rob Knight, Hongwei Zhou, Ye Chen
Article
Gastroenterology & Hepatology
Bingyun Lu, Jiamin Wang, Jing Li, Le Liu, Ye Chen
Article
Medicine, Research & Experimental
Lishan Zeng, Jiasheng Tan, Meng Xue, Le Liu, Mingming Wang, Liping Liang, Jun Deng, Wei Chen, Ye Chen
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Cell Biology
Ming-Yue Wu, Le Liu, Er-Jin Wang, Hai-Tao Xiao, Cui-Zan Cai, Jing Wang, Huanxing Su, Yitao Wang, Jieqiong Tan, Zhuohua Zhang, Juan Wang, Maojing Yao, De-Fang Ouyang, Zhenyu Yue, Min Li, Ye Chen, Zhao-Xiang Bian, Jia-Hong Lu
Summary: NRBF2, a regulatory subunit of the ATG14-BECN1/Beclin 1-PIK3C3/VPS34 complex, plays a crucial role in clearing apoptotic cells and alleviating colitis by promoting the fusion of phagosomes and lysosomes through the generation of active RAB7. Increased NRBF2 expression in colon macrophages is associated with a protective role in ulcerative colitis, highlighting the importance of apoptotic cell clearance in maintaining intestinal homeostasis and reducing inflammation.
Article
Gastroenterology & Hepatology
Haoran Ke, Jing Li, Bingyun Lu, Chenghai Yang, Jiamin Wang, Zhiqing Wang, Le Liu, Ye Chen
Summary: Double dose esomeprazole is associated with better intragastric acid suppression. A median 24-h intragastric pH of 5.7 could be an appropriate cutoff value for predicting the successful eradication of H. pylori. Bismuth-based quadruple therapy resulted in high H. pylori eradication rates in both PPI standard or double doses.
Article
Cell Biology
Shijie Mai, Le Liu, Jianjun Jiang, Pengfei Ren, Dingwei Diao, Haofei Wang, Kaican Cai
Summary: The study revealed an oncogenic role of IL-33 in promoting ESCC tumor growth by inducing M2-like macrophage differentiation through ODC activation. This suggests IL-33 as a potential novel target for cancer immunotherapy.
CELL PROLIFERATION
(2021)
Article
Nutrition & Dietetics
Youlian Zhou, Yan He, Le Liu, Wanyan Zhou, Pu Wang, Han Hu, Yuqiang Nie, Ye Chen
Summary: The study revealed differences in gut microbiota between Chinese and Western populations, as well as distinct microbial characteristics in UC and cCD patients in China. Gardnerella and Fusobacterium were identified as potential biomarkers for distinguishing between UC and cCD, demonstrating an important association between IBD affected bowel region and gut microbiota.
FRONTIERS IN NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Chenghai Yang, Liping Liang, Pinjing Lv, Le Liu, Siqi Wang, Zhiqing Wang, Ye Chen
Summary: The study found that supplementation of non-viable L. reuteri DSM17648 with triple therapy did not increase the eradication rate of H. pylori, but helped improve the gut microbiota and reduce the frequencies of abdominal distention, diarrhea, and overall gastrointestinal symptom rating.
Article
Biochemistry & Molecular Biology
Le Liu, Liping Liang, Genghui Mai, Ye Chen
Summary: This study identifies a 12-FAMRG risk signature for predicting prognosis and response to immunotherapy in colon adenocarcinoma (COAD). The risk signature is significantly correlated with prognosis and medication resistance in COAD patients. Additionally, the study reveals a strong correlation between the risk signature and immune cell infiltration and immune modulation.
Article
Gastroenterology & Hepatology
Le Liu, Liping Liang, Chenghai Yang, Youlian Zhou, Ye Chen
Summary: The study demonstrated that Fusobacterium nucleatum-derived extracellular vesicles induce epithelial cell death and gut barrier disruption in ulcerative colitis, potentially through the activation of receptor-interacting protein kinase 1 (RIPK1). These findings provide insights for further investigation of the disease.