Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

Cell therapy in chronic liver disease

(2016) Clara T. Nicolas et al.   CURRENT OPINION IN GASTROENTEROLOGY

Liver Fibrosis: From Pathogenesis to Novel Therapies

(2016) Ralf Weiskirchen et al.   DIGESTIVE DISEASES

Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice

(2016) Xiao-Feng Lei et al.   JOURNAL OF HEPATOLOGY

Crucial steps towards an effective treatment

(2016) Klaas Poelstra   Nature Reviews Gastroenterology & Hepatology

Human urokinase-type plasminogen activator gene-modified bone marrow-derived mesenchymal stem cells attenuate liver fibrosis in rats by down-regulating the Wnt signaling pathway

(2016) Zhi-Gang Ma   WORLD JOURNAL OF GASTROENTEROLOGY

Schistosomiasis Prevalence and Intensity of Infection in Latin America and the Caribbean Countries, 1942-2014: A Systematic Review in the Context of a Regional Elimination Goal

(2016) Ana Clara Zoni et al.   PLoS Neglected Tropical Diseases

Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis

(2016) Mio Kitano et al.   Journal of Clinical Medicine

Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution

(2016) Andrea Baiocchini et al.   PLoS One

Efficacy of Resveratrol Supplementation against Non-Alcoholic Fatty Liver Disease: A Meta-Analysis of Placebo-Controlled Clinical Trials

(2016) Chongyang Zhang et al.   PLoS One

Experimental models of liver fibrosis

(2015) Sara Crespo Yanguas et al.   ARCHIVES OF TOXICOLOGY

TGF-β induced miR-132 enhances the activation of TGF-β signaling through inhibiting SMAD7 expression in glioma cells

(2015) Zhao-hui Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Liver fibrosis, microbial translocation and immune activation markers in HIV and HCV infections and in HIV/HCV co-infection

(2015) Paolo Sacchi et al.   DIGESTIVE AND LIVER DISEASE

Pathophysiology of Liver Fibrosis

(2015) Massimo Pinzani   DIGESTIVE DISEASES

Tregs: A Therapeutic Target for the Treatment of Portal Fibrosis?

(2015) Yuhua Xue et al.   DIGESTIVE DISEASES AND SCIENCES

Lack of IL-17 signaling decreases liver fibrosis in murine schistosomiasis japonica

(2015) Yuxia Zhang et al.   INTERNATIONAL IMMUNOLOGY

Recent advancement of molecular mechanisms of liver fibrosis

(2015) Ekihiro Seki et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Mechanisms of liver fibrosis resolution

(2015) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

(2015) Cristina Bárcena et al.   JOURNAL OF HEPATOLOGY

24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis

(2015) Martina Sombetzki et al.   JOURNAL OF HEPATOLOGY

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Standard Operating Procedures in Experimental Liver Research: Thioacetamide model in mice and rats

(2015) MC Wallace et al.   LABORATORY ANIMALS

Assessing inflammatory liver injury in an acute CCl4model using dynamic 3D metabolic imaging of hyperpolarized [1-13C]pyruvate

(2015) Sonal Josan et al.   NMR IN BIOMEDICINE

The expression dynamics of transforming growth factor-β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis

(2015) Chao Yan et al.   Parasites & Vectors

miR-122 negatively correlates with liver fibrosis as detected by histology and FibroScan

(2015) Tünde Halász   WORLD JOURNAL OF GASTROENTEROLOGY

Liver fibrosis: Common mechanisms and antifibrotic therapies

(2015) Detlef Schuppan   Clinics and Research in Hepatology and Gastroenterology

Reversibility of liver fibrosis

(2015) Mengxi Sun et al.   Clinics and Research in Hepatology and Gastroenterology

Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression

(2015) Jia-Ru Wu et al.   Oncotarget

MicroRNA-17-5p-activated Wnt/β-catenin pathway contributes to the progression of liver fibrosis

(2015) Fujun Yu et al.   Oncotarget

Human liver myofibroblasts during development and diseases with a focus on portal (myo)fibroblasts

(2015) Sébastien Lepreux et al.   Frontiers in Physiology

Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging

(2015) Dan Li et al.   EJNMMI Research

Progression of Liver Fibrosis in HIV/HCV Co-Infection: A Comparison between Non-Invasive Assessment Methods and Liver Biopsy

(2015) Patrick Schmid et al.   PLoS One

microRNA-222 modulates liver fibrosis in a murine model of biliary atresia

(2014) Wen-jun Shen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of adipose tissue in methionine–choline-deficient model of non-alcoholic steatohepatitis (NASH)

(2014) Pooja Jha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells

(2014) Ki Cheong Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway

(2014) Ju-Hee Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

Mest Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting the Wnt/β-Catenin Signaling Pathway

(2014) Wenting Li et al.   Gut and Liver

Association of Periodontal Diseases and Liver Fibrosis in Patients With HCV and/or HBV infection

(2014) Yumiko Nagao et al.   Hepatitis Monthly

IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice

(2014) Abhisek Mitra et al.   HEPATOLOGY

Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells

(2014) Kengo Tomita et al.   JOURNAL OF HEPATOLOGY

Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis

(2014) Mark A. Barnes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Failure of Repeated Treatment With Praziquantel and Arthemeter in Four Patients With Acute Schistosomiasis

(2014) Liliana Praticò et al.   JOURNAL OF TRAVEL MEDICINE

Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology

(2014) Candy Chuah et al.   TRENDS IN PARASITOLOGY

SMAD7: a timer of tumor progression targeting TGF-β signaling

(2014) Lingyu Luo et al.   TUMOR BIOLOGY

Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update

(2014) Gülsüm Özlem Elpek   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases

(2013) Yong He et al.   BIOCHIMIE

Wnt signaling in liver fibrosis: Progress, challenges and potential directions

(2013) Cheng-gui Miao et al.   BIOCHIMIE

Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis

(2013) Oriol Morales-Ibanez et al.   HEPATOLOGY

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

(2013) Jean-Philippe Pradere et al.   HEPATOLOGY

Osteopontin: Versatile modulator of liver diseases

(2013) Sumiko Nagoshi   HEPATOLOGY RESEARCH

Reversion of hepatic stellate cell to a quiescent phenotype: From myth to reality?

(2013) Ariane Mallat et al.   JOURNAL OF HEPATOLOGY

Impaired CD4+ T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients

(2013) Andreas Glässner et al.   JOURNAL OF HEPATOLOGY

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

Carbon tetrachloride-induced lipid peroxidation and hyperglycemia in rat

(2013) Rahmat Ali Khan et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Differential effects of low-dose resveratrol on adiposity and hepatic steatosis in diet-induced obese mice

(2012) Su-Jung Cho et al.   BRITISH JOURNAL OF NUTRITION

Inflammation and fibrogenesis in steatohepatitis

(2012) Hideki Fujii et al.   JOURNAL OF GASTROENTEROLOGY

HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis

(2012) Da-Wei Zhang et al.   JOURNAL OF HEPATOLOGY

Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats

(2012) Marco Di Pascoli et al.   JOURNAL OF HEPATOLOGY

miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis

(2012) Christoph Roderburg et al.   JOURNAL OF HEPATOLOGY

The Osteopontin Level in Liver, Adipose Tissue and Serum Is Correlated with Fibrosis in Patients with Alcoholic Liver Disease

(2012) Stéphanie Patouraux et al.   PLoS One

Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B

(2012) G. Sitia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effects and Mechanisms of Acremoniumterricola milleretal mycelium on Liver Fibrosis Induced by Carbon Tetrachloride in Rats

(2011) Xiao-Peng Tian et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Effects of resveratrol on biomarkers of oxidative stress and on the activity of delta aminolevulinic acid dehydratase in liver and kidney of streptozotocin-induced diabetic rats

(2011) Roberta Schmatz et al.   BIOCHIMIE

The Progression of Liver Fibrosis Is Related with Overexpression of the miR-199 and 200 Families

(2011) Yoshiki Murakami et al.   PLoS One

Endothelial Nrf2 activation: a new target for resveratrol?

(2010) György Haskó et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Bariatric Surgery-Induced Weight Loss Reduces Hepatic Lipid Peroxidation Levels and Affects Hepatic Cytochrome P-450 Protein Content

(2010) Lauren N. Bell et al.   ANNALS OF SURGERY

Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells

(2010) Xu Wang et al.   JOURNAL OF HEPATOLOGY

AMP-Activated Protein Kinase-Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

(2009) J.-H. Um et al.   DIABETES

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

(2009) Ramon Amat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: An essential role for apoptosis

(2009) Can-Jie Guo et al.   JOURNAL OF HEPATOLOGY

Carbogen Gas–Challenge BOLD MR Imaging in a Rat Model of Diethylnitrosamine-induced Liver Fibrosis

(2009) Ning Jin et al.   RADIOLOGY

Resveratrol alleviates alcoholic fatty liver in mice

(2008) Joanne M. Ajmo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet

(2008) Jiyun Ahn et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease: The mist gradually clears

(2008) Nimantha Mark Wilfred de Alwis et al.   JOURNAL OF HEPATOLOGY

The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model

(2008) Angelica Butura et al.   JOURNAL OF HEPATOLOGY

CYP2E1 and oxidative liver injury by alcohol

(2007) Yongke Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE