Induction of HO-1 by 5, 8-Dihydroxy-4 ′ ,7-Dimethoxyflavone via Activation of ROS/p38 MAPK/Nrf2 Attenuates Thrombin-Induced Connective Tissue Growth Factor Expression in Human Cardiac Fibroblasts

Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation

(2020) Chih-Chung Lin et al.   Journal of Clinical Medicine

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases

(2020) Xueyan Zhang et al.   Cardiology Research and Practice

Investigation of expression and influence of CTGF and HO-1 in rats with diabetic retinopathy

(2019) Yongjian Huang et al.   Experimental and Therapeutic Medicine

ADAM17/EGFR-dependent ERK activation mediates thrombin-induced CTGF expression in human lung fibroblasts

(2018) Hui-Yu Chen et al.   EXPERIMENTAL CELL RESEARCH

ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection

(2018) Susana Cadenas   FREE RADICAL BIOLOGY AND MEDICINE

Thrombin induces protease-activated receptor 1 signaling and activation of human atrial fibroblasts and dabigatran prevents these effects

(2018) Paola Altieri et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Connective tissue growth factor (CTGF) from basics to clinics

(2018) Yasaman Ramazani et al.   MATRIX BIOLOGY

Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation

(2018) Rou-Ling Cho et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence

(2018) Huitong Shan et al.   EBioMedicine

Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice

(2017) Zheng Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice

(2017) Anping Dong et al.   THROMBOSIS RESEARCH

Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes

(2016) Yeon-Hui Jeong et al.   Biomolecules & Therapeutics

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway

(2016) Sally H. Latham Birt et al.   JOURNAL OF LIPID RESEARCH

Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK

(2016) Siew Ying Wong et al.   Journal of Neuroinflammation

Medicinal uses, phytochemistry and pharmacology of family Sterculiaceae: A review

(2015) L.M.R. Al Muqarrabun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Dihydroquercetin (DHQ) ameliorated concanavalin A-induced mouse experimental fulminant hepatitis and enhanced HO-1 expression through MAPK/Nrf2 antioxidant pathway in RAW cells

(2015) Mingyi Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Circulating Biomarkers of Myocardial Fibrosis

(2015) Begoña López et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague–Dawley rats

(2014) Miao Yu et al.   FOOD AND CHEMICAL TOXICOLOGY

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(2014) Jing Huang et al.   MOLECULAR MEDICINE

CO Induces Nrf2-Dependent Heme Oxygenase-1 Transcription by Cooperating with Sp1 and c-Jun in Rat Brain Astrocytes

(2014) Pei-Ling Chi et al.   MOLECULAR NEUROBIOLOGY

The Role of Nrf2-Mediated Pathway in Cardiac Remodeling and Heart Failure

(2014) Shanshan Zhou et al.   Oxidative Medicine and Cellular Longevity

Epidermal Growth Factor Stimulates Nuclear Factor-κB Activation and Heme Oxygenase-1 Expression via c-Src, NADPH Oxidase, PI3K, and Akt in Human Colon Cancer Cells

(2014) Gi-Shih Lien et al.   PLoS One

Heme Oxygenase-1 As a Target for Drug Discovery

(2013) Roberto Motterlini et al.   ANTIOXIDANTS & REDOX SIGNALING

Cytotoxic cardenolide glycosides from the root of Reevesia formosana

(2013) Hsun-Shuo Chang et al.   PHYTOCHEMISTRY

Trolox contributes to Nrf2-mediated protection of human and murine primary alveolar type II cells from injury by cigarette smoke

(2013) E M Messier et al.   Cell Death & Disease

Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway

(2012) Wen-chin Ko et al.   ACTA PHARMACOLOGICA SINICA

Oxidative stress and heart failure

(2011) Hiroyuki Tsutsui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress

(2011) Ya-Chen Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

(2011) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart

(2010) Guangwu Wang et al.   CIRCULATION

NADPH oxidases and cardiac remodelling

(2010) Adam Nabeebaccus et al.   HEART FAILURE REVIEWS

Mitochondria-Derived Reactive Oxygen Species Mediate Heme Oxygenase-1 Expression in Sheared Endothelial Cells

(2009) Z. Han et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Connective tissue growth factor and cardiac fibrosis

(2008) A. Daniels et al.   Acta Physiologica

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH