Journal
FOOD & FUNCTION
Volume 13, Issue 5, Pages 2441-2455Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1fo03486c
Keywords
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Funding
- Mushroom Technology System of Shandong Province [SDAIT-07-05]
- Shandong Key Research and Development Program [2019GSF107208]
- Sanshu Biotech Co. Ltd (Jiangsu, China)
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This study found that PGPs from Pleurotus geesteranus could potentially prevent ALD by reducing oxidative stress and inflammation, as well as balancing the gut-liver axis through maintaining intestinal barrier integrity and regulating microbiota composition.
This study investigated the effects of PGPs (Pleurotus geesteranus polysaccharides), a glucopyranose isolated from the mycelium of Pleurotus geesteranus and characterized with the main chain of -> 4)-alpha-d-Glcp-(1 ->, on the prevention against alcohol liver diseases (ALD), with the aim of providing a theoretical basis for the application of P. geesteranus as prebiotic agents in preventing and treating gut dysbiosis and alcohol-related metabolic disorders in individuals with ALD. The results showed that PGP treatment reduced oxidative stress by up-regulating the Nrf2/HO-1 signalling pathways, and decreased the pro-inflammatory factors by down-regulating TLR4/NF-kappa B signalling pathways. Furthermore, we validated effects of PGPs on balancing the gut-liver axis by maintaining the integrity of the intestinal epithelial barrier of decreasing intestinal permeability, increasing intestinal tight-junction protein and mucin expression and elevating the abundance of short-chain fatty acids (SCFAs) producers in the intestine by regulating the microbiota composition.
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