NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch

NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer

(2020) Séan M. O'Cathail et al.   Cancer Genetics

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

(2020) Laura Torrente et al.   Biomolecules

The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase

(2019) Viraj R. Sanghvi et al.   CELL

Neoadjuvant rectal score as individual-level surrogate for disease-free survival in rectal cancer in the CAO/ARO/AIO-04 randomized phase III trial

(2018) E Fokas et al.   ANNALS OF ONCOLOGY

Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer

(2018) Akhileshwar Namani et al.   BMC CANCER

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

(2018) Jonathan P. Evans et al.   Oncotarget

A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations

(2018) Daniel C. Levings et al.   Redox Biology

Tumor Regression Grading After Preoperative Chemoradiotherapy as a Prognostic Factor and Individual-Level Surrogate for Disease-Free Survival in Rectal Cancer

(2017) Emmanouil Fokas et al.   JNCI-Journal of the National Cancer Institute

Integrated genomic characterization of oesophageal carcinoma

(2017)   NATURE

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

Role of Nrf2 signaling pathway in the radiation tolerance of patients with head and neck squamous cell carcinoma: an in vivo and in vitro study

(2017) Tao Wang et al.   OncoTargets and Therapy

Tumor Regression Grading After Preoperative Chemoradiotherapy as a Prognostic Factor and Individual-Level Surrogate for Disease-Free Survival in Rectal Cancer

(2017) Emmanouil Fokas et al.   JNCI-Journal of the National Cancer Institute

The NRF2 transcription factor plays a dual role in colorectal cancer: A systematic review

(2017) C. Gonzalez-Donquiles et al.   PLoS One

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

(2016) Iok In Christine Chio et al.   CELL

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor

(2016) Abigail S. Krall et al.   Nature Communications

Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells

(2016) Kyoung Ah Kang et al.   Oncotarget

Nrf2 promotes survival following exposure to ionizing radiation

(2015) Konjeti R. Sekhar et al.   FREE RADICAL BIOLOGY AND MEDICINE

NRF2 regulates serine biosynthesis in non–small cell lung cancer

(2015) Gina M DeNicola et al.   NATURE GENETICS

CFAssay: statistical analysis of the colony formation assay

(2015) Herbert Braselmann et al.   Radiation Oncology

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs

(2014) Xiu Jun Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapyin vitroandin vivo

(2013) Melanie Spitzner et al.   INTERNATIONAL JOURNAL OF CANCER

Methylation of the KEAP1 gene promoter region in human colorectal cancer

(2012) Naoyuki Hanada et al.   BMC CANCER

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Somatic mutations of the KEAP1 gene in common solid cancers

(2012) Nam Jin Yoo et al.   HISTOPATHOLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Gain of Nrf2 Function in Non-Small-Cell Lung Cancer Cells Confers Radioresistance

(2010) Anju Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS