Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains

(2011) Frances Corrigan et al.   BRAIN RESEARCH

Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragmentsin Vivo

(2011) Tamara Jefferson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1

(2011) Rachel F Lane et al.   Molecular Neurodegeneration

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Insulin-like Growth Factor-1 (IGF-1)-induced Processing of Amyloid-β Precursor Protein (APP) and APP-like Protein 2 Is Mediated by Different Metalloproteinases

(2010) Kristin T. Jacobsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

Retinoids as a Perspective in Treatment of Alzheimer’s Disease

(2010) Falk Fahrenholz et al.   Neurodegenerative Diseases

APP Processing Induced by Herpes Simplex Virus Type 1 (HSV-1) Yields Several APP Fragments in Human and Rat Neuronal Cells

(2010) Giovanna De Chiara et al.   PLoS One

Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein

(2010) S. O. Dahms et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid

(2009) Erik Portelius et al.   EXPERIMENTAL NEUROLOGY

Interaction of Reelin with Amyloid Precursor Protein Promotes Neurite Outgrowth

(2009) H.-S. Hoe et al.   JOURNAL OF NEUROSCIENCE

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Protein kinase C-dependent α-secretory processing of the amyloid precursor protein is mediated by phosphorylation of myosin II-B

(2008) Francesca Argellati et al.   FASEB JOURNAL

Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect β-Secretase Cleavage of APP

(2008) Daniela Kaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth

(2008) BE Needham et al.   JOURNAL OF PATHOLOGY

Brain-derived neurotrophic factor stimulates β-amyloid gene promoter activity by a Ras-dependent/AP-1-independent mechanism in SH-SY5Y neuroblastoma cells

(2003) Yolanda Ruiz-León et al.   JOURNAL OF NEUROCHEMISTRY