Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2

Regulation of Inflammation and Oxidative Stress by Formyl Peptide Receptors in Cardiovascular Disease Progression

(2021) Valentina Maria Caso et al.   Life-Basel

Structures of the human cholecystokinin receptors bound to agonists and antagonists

(2021) Xuefeng Zhang et al.   Nature Chemical Biology

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

(2020) Youwen Zhuang et al.   Nature Communications

The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer

(2020) Weiwei Liang et al.   Frontiers in Endocrinology

Dual modulation of formyl peptide receptor 2 by aspirin‐triggered lipoxin contributes to its anti‐inflammatory activity

(2020) Yunjun Ge et al.   FASEB JOURNAL

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure

(2020) Yoshikazu Asahina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity

(2020) Ursula Smole et al.   NATURE IMMUNOLOGY

Biased allosteric modulation of formyl peptide receptor 2 leads to distinct receptor conformational states for pro- and anti-inflammatory signaling

(2020) Shuo Zhang et al.   PHARMACOLOGICAL RESEARCH

Formyl peptide receptor type 2 agonists to kick‐start resolution pharmacology

(2020) Mauro Perretti et al.   BRITISH JOURNAL OF PHARMACOLOGY

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Conformational transitions of a neurotensin receptor 1–Gi1 complex

(2019) Hideaki E. Kato et al.   NATURE

FPR1 is the plague receptor on host immune cells

(2019) Patrick Osei-Owusu et al.   NATURE

The contribution of formyl peptide receptor dysfunction to the course of neuroinflammation: A potential role in the brain pathology.

(2019) Ewa Trojan et al.   Current Neuropharmacology

Common activation mechanism of class A GPCRs

(2019) Qingtong Zhou et al.   eLife

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

Targeting formyl peptide receptors to facilitate the resolution of inflammation

(2018) János G. Filep et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Orthosteric and allosteric action of the C5a receptor antagonists

(2018) Heng Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Orthosteric and allosteric action of the C5a receptor antagonists

(2018) Heng Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

(2018) Timothy F Miles et al.   eLife

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

Formyl-Peptide Receptors in Infection, Inflammation, and Cancer

(2018) Elisabeth Weiß et al.   TRENDS IN IMMUNOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Biased perspectives on formyl peptide receptors

(2018) Carsten Alexander Raabe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of inflammation by members of the formyl-peptide receptor family

(2017) Keqiang Chen et al.   JOURNAL OF AUTOIMMUNITY

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition

(2017) Hui-Qiong He et al.   MOLECULES

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer

(2016) Ping Liu et al.   ACTA PHARMACOLOGICA SINICA

Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949

(2016) Anna K. Stalder et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Formyl peptide receptor modulators: a patent review and potential applications for inflammatory diseases (2012-2015)

(2016) Yung-Fong Tsai et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation

(2015) David A. Dorward et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Propagation of conformational changes during μ-opioid receptor activation

(2015) Rémy Sounier et al.   NATURE

Formyl peptide receptors at the interface of inflammation, angiogenesis and tumor growth

(2015) Nella Prevete et al.   PHARMACOLOGICAL RESEARCH

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity

(2015) Jeffrey Klarenbeek et al.   PLoS One

Development of Small Molecule Non-peptide Formyl Peptide Receptor (FPR) Ligands and Molecular Modeling of Their Recognition

(2014) I.A. Schepetkin et al.   CURRENT MEDICINAL CHEMISTRY

FPR2/ALXR Agonists and the Resolution of Inflammation

(2014) Olivier Corminboeuf et al.   JOURNAL OF MEDICINAL CHEMISTRY

Distinct Signaling Cascades Elicited by Different Formyl Peptide Receptor 2 (FPR2) Agonists

(2013) Fabio Cattaneo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Determinants for the Interaction of Formyl Peptide Receptor 2 with Peptide Ligands

(2013) Hui-Qiong He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies

(2012) B. Trzaskowski et al.   CURRENT MEDICINAL CHEMISTRY

Structural insights into agonist-induced activation of G-protein-coupled receptors

(2011) Xavier Deupi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Pyrazolone Originally Reported to Be a Formyl Peptide Receptor (FPR) 2/ALX–Selective Agonist Is Instead an FPR1 and FPR2/ALX Dual Agonist

(2009) Yoshitaka Sogawa et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects

(2008) I. Hecht et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS