Regulation of Inflammation and Oxidative Stress by Formyl Peptide Receptors in Cardiovascular Disease Progression

Pro-Resolving FPR2 Agonists Regulate NADPH Oxidase-Dependent Phosphorylation of HSP27, OSR1, and MARCKS and Activation of the Respective Upstream Kinases

(2021) Rosario Ammendola et al.   Antioxidants

The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer

(2020) Weiwei Liang et al.   Frontiers in Endocrinology

Phosphorylation Sites in Protein Kinases and Phosphatases Regulated by Formyl Peptide Receptor 2 Signaling

(2020) Maria Carmela Annunziata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure

(2020) Yoshikazu Asahina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Single-Photon Emission Computed Tomography Imaging Using Formyl Peptide Receptor 1 Ligand Can Diagnose Aortic Aneurysms in a Mouse Model

(2020) Alexander H. Shannon et al.   JOURNAL OF SURGICAL RESEARCH

[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs

(2020) Yu Ding et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Formyl peptide receptor type 2 agonists to kick‐start resolution pharmacology

(2020) Mauro Perretti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Acute cigarette smoke‐induced eQTL affects formyl peptide receptor expression and lung function

(2020) Simon D. Pouwels et al.   RESPIROLOGY

The formyl peptide fMLF primes platelet activation and augments thrombus formation

(2019) Maryam F. Salamah et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation

(2019) Elena Y. Senchenkova et al.   CIRCULATION

Chemotactic Ligands that Activate G-Protein-Coupled Formylpeptide Receptors

(2019) Stacey A Krepel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair

(2019) Bartolo Ferraro et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Annexin-A1: Therapeutic Potential in Microvascular Disease

(2019) Gareth S. D. Purvis et al.   Frontiers in Immunology

Inhibition of FPR2 impaired leukocytes recruitment and elicited non-resolving inflammation in acute heart failure

(2019) Vasundhara Kain et al.   PHARMACOLOGICAL RESEARCH

The contribution of formyl peptide receptor dysfunction to the course of neuroinflammation: A potential role in the brain pathology.

(2019) Ewa Trojan et al.   Current Neuropharmacology

RvD1binding with FPR2 attenuates inflammation via Rac1/NOX2 pathway after neonatal hypoxic-ischemic injury in rats

(2019) Wei Liu et al.   EXPERIMENTAL NEUROLOGY

Phosphoproteomic analysis sheds light on intracellular signaling cascades triggered by Formyl-Peptide Receptor 2

(2019) Fabio Cattaneo et al.   Scientific Reports

Mitochondrial dysfunction and oxidative stress in heart disease

(2019) Jessica N. Peoples et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

NOX2-Dependent Reactive Oxygen Species Regulate Formyl-Peptide Receptor 1-Mediated TrkA Transactivation in SH-SY5Y Cells

(2019) Martina Castaldo et al.   Oxidative Medicine and Cellular Longevity

Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure

(2019) Bochra Tourki et al.   Molecular Metabolism

Metabolic Alterations in Cardiomyocytes of Patients with Duchenne and Becker Muscular Dystrophies

(2019) Gabriella Esposito et al.   Journal of Clinical Medicine

Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm DevelopmentHighlights

(2018) Li He et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis

(2018) Milka Koupenova et al.   CIRCULATION RESEARCH

FPR1 gene silencing suppresses cardiomyocyte apoptosis and ventricular remodeling in rats with ischemia/reperfusion injury through the inhibition of MAPK signaling pathway

(2018) Qing-Ling Zhou et al.   EXPERIMENTAL CELL RESEARCH

Akap1Regulates Vascular Function and Endothelial Cells BehaviorNovelty and Significance

(2018) Gabriele Giacomo Schiattarella et al.   HYPERTENSION

Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury

(2018) Junaid Ansari et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease

(2018) Yung-Che Chen et al.   Journal of Translational Medicine

Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease

(2018) Roberto Russo et al.   NEUROBIOLOGY OF AGING

Formyl Peptide Receptor 1 Modulates Endothelial Cell Functions by NADPH Oxidase-Dependent VEGFR2 Transactivation

(2018) Fabio Cattaneo et al.   Oxidative Medicine and Cellular Longevity

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

(2018) Joachim Pircher et al.   Nature Communications

Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

(2018) Gabriele G. Schiattarella et al.   Frontiers in Physiology

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)

(2018) Monica de Gaetano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease

(2018) John Pirault et al.   Frontiers in Pharmacology

Novel ureidopropanamide based N -formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation

(2017) Madia Letizia Stama et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biosynthesis of proresolving lipid mediators by vascular cells and tissues

(2017) Anuran Chatterjee et al.   FASEB JOURNAL

Identification of Transcription Factor-Gene Regulatory Network in Acute Myocardial Infarction

(2017) Yuejuan Cao et al.   Heart Lung and Circulation

Regulation of inflammation by members of the formyl-peptide receptor family

(2017) Keqiang Chen et al.   JOURNAL OF AUTOIMMUNITY

Intravital Imaging of Neutrophil Recruitment Reveals the Efficacy of FPR1 Blockade in Hepatic Ischemia-Reperfusion Injury

(2017) Masaki Honda et al.   JOURNAL OF IMMUNOLOGY

Biomarkers identification for acute myocardial infarction detection via weighted gene co-expression network analysis

(2017) Shu Zhang et al.   MEDICINE

The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition

(2017) Hui-Qiong He et al.   MOLECULES

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

(2017) Cheng Xue Qin et al.   Nature Communications

VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells

(2017) Francesco Lodola et al.   Oncotarget

Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing

(2017) Vasundhara Kain et al.   Scientific Reports

Chronic Obstructive Pulmonary Disease and Cardiac Diseases. An Urgent Need for Integrated Care

(2016) Sara Roversi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nuclear localization of Formyl-Peptide Receptor 2 in human cancer cells

(2016) Fabio Cattaneo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE

(2016) Yikui Tian et al.   BASIC RESEARCH IN CARDIOLOGY

Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and mitochondria

(2016) Claes Dahlgren et al.   BIOCHEMICAL PHARMACOLOGY

Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis

(2016) Jung-Woo Kang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949

(2016) Anna K. Stalder et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Formyl-Peptide Receptor 2/3/Lipoxin A4Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral InflammationCLINICAL PERSPECTIVE

(2016) Shantel A. Vital et al.   CIRCULATION

Serum amyloid A and atherosclerosis

(2016) Godfrey S. Getz et al.   CURRENT OPINION IN LIPIDOLOGY

D-series resolvins inhibit murine abdominal aortic aneurysm formation and increase M2 macrophage polarization

(2016) Nicolas H. Pope et al.   FASEB JOURNAL

Formyl Peptide Receptor 2 Is Involved in Cardiac Repair After Myocardial Infarction Through Mobilization of Circulating Angiogenic Cells

(2016) Soon Chul Heo et al.   STEM CELLS

Biomedical therapy using synthetic WKYMVm hexapeptide

(2016) Young Hwan Choi et al.   Organogenesis

Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis

(2016) Gabriele Giacomo Schiattarella et al.   PLoS One

Injectable PLGA microspheres encapsulating WKYMVM peptide for neovascularization

(2015) Young Hwan Choi et al.   Acta Biomaterialia

The Role of Formylated Peptides and Formyl Peptide Receptor 1 in Governing Neutrophil Function during Acute Inflammation

(2015) David A. Dorward et al.   AMERICAN JOURNAL OF PATHOLOGY

The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

(2015) Kiichi Nakahira et al.   ANTIOXIDANTS & REDOX SIGNALING

Dermcidin: a skeletal muscle myokine modulating cardiomyocyte survival and infarct size after coronary artery ligation

(2015) Giovanni Esposito et al.   CARDIOVASCULAR RESEARCH

wRAPping Up Early Monocyte and Neutrophil Recruitment in Atherogenesis via AnnexinA1/FPR2 Signaling

(2015) M. J. Butcher et al.   CIRCULATION RESEARCH

Targeting formyl peptide receptor 2 reduces leukocyte-endothelial interactions in a murine model of stroke

(2015) Helen K. Smith et al.   FASEB JOURNAL

Resolvin D1 protects against hepatic ischemia/reperfusion injury in rats

(2015) Tao Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulation of atherosclerotic plaque inflammation

(2015) M. Bäck et al.   JOURNAL OF INTERNAL MEDICINE

New development in studies of formyl-peptide receptors: critical roles in host defense

(2015) L. Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Effect of a novel peptide, WKYMVm- and sirolimus-coated stent on re-endothelialization and anti-restenosis

(2015) Eun-Jae Jang et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function

(2015) Vasundhara Kain et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

(2015) Gabrielle Fredman et al.   Science Translational Medicine

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet

(2015) Dennis H. M. Kusters et al.   PLoS One

The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability

(2014) Marcelo H. Petri et al.   CARDIOVASCULAR RESEARCH

FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages

(2014) Wenyan Wang et al.   Cellular & Molecular Immunology

Cell-Surface Receptors Transactivation Mediated by G Protein-Coupled Receptors

(2014) Fabio Cattaneo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FPR2/ALXR Agonists and the Resolution of Inflammation

(2014) Olivier Corminboeuf et al.   JOURNAL OF MEDICINAL CHEMISTRY

The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis

(2014) N Prevete et al.   ONCOGENE

Formylpeptide Receptors Mediate Rapid Neutrophil Mobilization to Accelerate Wound Healing

(2014) Mingyong Liu et al.   PLoS One

Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage

(2014) Quan Liu et al.   Journal of Diabetes Investigation

High prevalence of altered cardiac repolarization in patients with COPD

(2014) Noriane A Sievi et al.   BMC Pulmonary Medicine

Role of formyl peptide receptor 2 on the serum amyloid A-induced macrophage foam cell formation

(2013) Ha Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2

(2013) Ha Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

WKYMVm-induced cross-talk between FPR2 and HGF receptor in human prostate epithelial cell line PNT1A

(2013) Fabio Cattaneo et al.   FEBS LETTERS

Distinct Signaling Cascades Elicited by Different Formyl Peptide Receptor 2 (FPR2) Agonists

(2013) Fabio Cattaneo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum amyloid A activation of human coronary artery endothelial cells exhibits a neutrophil promoting molecular profile

(2013) Katja Lakota et al.   MICROVASCULAR RESEARCH

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WKYMVm-Induced Activation of Formyl Peptide Receptor 2 Stimulates Ischemic Neovasculogenesis by Promoting Homing of Endothelial Colony-Forming Cells

(2013) Soon Chul Heo et al.   STEM CELLS

Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A12-26

(2012) Chengxue Qin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Leukocyte chemoattractant receptor FPR2 may accelerate atherogenesis

(2012) Wuzhou Wan et al.   MEDICAL HYPOTHESES

Oxidative stress and cardiac hypertrophy: a review

(2012) Subir Kumar Maulik et al.   TOXICOLOGY MECHANISMS AND METHODS

Annexin A1 and the regulation of innate and adaptive immunity

(2012) Felicity N. E. Gavins et al.   Frontiers in Immunology

Annexin 1 Released by Necrotic Human Glioblastoma Cells Stimulates Tumor Cell Growth through the Formyl Peptide Receptor 1

(2011) Yan Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxidative stress and heart failure

(2011) Hiroyuki Tsutsui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NADPH-oxidase-dependent reactive oxygen species mediate EGFR transactivation by FPRL1 in WKYMVm-stimulated human lung cancer cells

(2011) Fabio Cattaneo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome

(2011) Michal Pravenec et al.   HYPERTENSION

Chemical Mediators of Inflammation and Resolution in Post-Operative Abdominal Aortic Aneurysm Patients

(2011) Padmini S. Pillai et al.   INFLAMMATION

N-Formyl Peptide Receptor 3 (FPR3) Departs from the Homologous FPR2/ALX Receptor with Regard to the Major Processes Governing Chemoattractant Receptor Regulation, Expression at the Cell Surface, and Phosphorylation

(2011) Marie-Josèphe Rabiet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ptx3, a key component of innate immunity, is induced by saa via fprl1-mediated signaling in HAECs

(2011) Zhe Dong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Human formyl peptide receptor 1 C32T SNP interacts with age and is associated with blood pressure levels

(2010) Said El Shamieh et al.   CLINICA CHIMICA ACTA

Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2

(2010) Thippadey Khau et al.   FASEB JOURNAL

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Expression and Signaling of Formyl-Peptide Receptors in the Brain

(2010) Fabio Cattaneo et al.   NEUROCHEMICAL RESEARCH

Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists

(2010) Neil Dufton et al.   PHARMACOLOGY & THERAPEUTICS

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia–reperfusion injury?

(2010) Felicity N.E. Gavins   TRENDS IN PHARMACOLOGICAL SCIENCES

Immune Cells and Molecular Mediators in the Pathogenesis of the Abdominal Aortic Aneurysm

(2009) Konstantinos D. Rizas et al.   Cardiology in Review

Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus

(2009) Xavier Houard et al.   FASEB JOURNAL

Annexin-1 Regulates Macrophage IL-6 and TNF via Glucocorticoid-Induced Leucine Zipper

(2009) Y. H. Yang et al.   JOURNAL OF IMMUNOLOGY

Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels

(2009) Hamanou Benachour et al.   PHARMACOGENOMICS

FPRL1-mediated induction of superoxide in LL-37-stimulated IMR90 human fibroblast

(2008) Annalisa Iaccio et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Annexin-1 peptide Anx-12-26 protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia

(2005) Rebecca H Ritchie et al.   BRITISH JOURNAL OF PHARMACOLOGY