Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection

(2015) Andreas Krause et al.   CLINICAL PHARMACOKINETICS

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

(2014) Magnus Bäck et al.   BRITISH JOURNAL OF PHARMACOLOGY

Plasma Levels of IL-37 and Correlation with TNF-α, IL-17A, and Disease Activity during DMARD Treatment of Rheumatoid Arthritis

(2014) Ping-Wei Zhao et al.   PLoS One

Distinct Signaling Cascades Elicited by Different Formyl Peptide Receptor 2 (FPR2) Agonists

(2013) Fabio Cattaneo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proresolving and Tissue-Protective Actions of Annexin A1-Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor

(2013) J. Dalli et al.   JOURNAL OF IMMUNOLOGY

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist

(2013) Brian R Leaker et al.   RESPIRATORY RESEARCH

An Enhanced ELISPOT Assay for Sensitive Detection of Antigen-Specific T Cell Responses to Borrelia burgdorferi

(2013) Chenggang Jin et al.   Cells

LPS challenge in healthy subjects: An investigation of neutrophil chemotaxis mechanisms involving CXCR1 and CXCR2

(2012) Raminder Aul et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis

(2012) Juliana P. Vago et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Agonist-Directed Desensitization of the β2-Adrenergic Receptor

(2011) Vasiliy Goral et al.   PLoS One

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis

(2010) Paola Maderna et al.   FASEB JOURNAL

Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

(2010) Neil Dufton et al.   JOURNAL OF IMMUNOLOGY

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Agonist-specific patterns of β2-adrenoceptor responses in human airway cells during prolonged exposure

(2009) Caroline Düringer et al.   BRITISH JOURNAL OF PHARMACOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Structure-based discovery of  2-adrenergic receptor ligands

(2009) P. Kolb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA