The Formyl Peptide Receptors: Diversity of Ligands and Mechanism for Recognition

Intravital Imaging of Neutrophil Recruitment Reveals the Efficacy of FPR1 Blockade in Hepatic Ischemia-Reperfusion Injury

(2017) Masaki Honda et al.   JOURNAL OF IMMUNOLOGY

The peptidomimetic Lau-(Lys-βNSpe)6-NH2 antagonizes formyl peptide receptor 2 expressed in mouse neutrophils

(2016) Sarah Line Skovbakke et al.   BIOCHEMICAL PHARMACOLOGY

Basic characteristics of the neutrophil receptors that recognize formylated peptides, a danger-associated molecular pattern generated by bacteria and mitochondria

(2016) Claes Dahlgren et al.   BIOCHEMICAL PHARMACOLOGY

A pepducin designed to modulate P2Y 2 R function interacts with FPR2 in human neutrophils and transfers ATP to an NADPH-oxidase-activating ligand through a receptor cross-talk mechanism

(2016) Michael Gabl et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Promotion of formyl peptide receptor 1-mediated neutrophil chemotactic migration by antimicrobial peptides isolated from the centipede Scolopendra subspinipes mutilans

(2016) Yoo Jung Park et al.   BMB Reports

Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives

(2016) Igor A. Schepetkin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Identification of FAM3D as a new endogenous chemotaxis agonist for the formyl peptide receptors

(2016) Xinjian Peng et al.   JOURNAL OF CELL SCIENCE

The proteolytically stable peptidomimetic Pam-(Lys-βNSpe)6-NH2 selectively inhibits human neutrophil activation via formyl peptide receptor 2

(2015) Sarah Line Skovbakke et al.   BIOCHEMICAL PHARMACOLOGY

Structural changes of the ligand and of the receptor alters the receptor preference for neutrophil activating peptides starting with a formylmethionyl group

(2015) Huamei Forsman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Non-peptide ligand binding to the formyl peptide receptor FPR2—A comparison to peptide ligand binding modes

(2015) Tomasz M. Stepniewski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2

(2015) Enza Lacivita et al.   BIOORGANIC & MEDICINAL CHEMISTRY

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

A neutrophil inhibitory pepducin derived from FPR1 expected to target FPR1 signaling hijacks the closely related FPR2 instead

(2015) Malene Winther et al.   FEBS LETTERS

New development in studies of formyl-peptide receptors: critical roles in host defense

(2015) L. Li et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Peptide length and folding state govern the capacity of staphylococcal β-type phenol-soluble modulins to activate human formyl-peptide receptors 1 or 2

(2015) Dorothee Kretschmer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Adaptive Evolution of Formyl Peptide Receptors in Mammals

(2015) Yoshinori Muto et al.   JOURNAL OF MOLECULAR EVOLUTION

Formyl peptide receptors at the interface of inflammation, angiogenesis and tumor growth

(2015) Nella Prevete et al.   PHARMACOLOGICAL RESEARCH

Cyclization of the Urokinase Receptor-Derived Ser-Arg-Ser-Arg-Tyr Peptide Generates a Potent Inhibitor of Trans-Endothelial Migration of Monocytes

(2015) Ali Munaim Yousif et al.   PLoS One

Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones

(2014) Igor A. Schepetkin et al.   BIOCHEMICAL PHARMACOLOGY

Development of potent antagonists for formyl peptide receptor 1 based on Boc-Phe-d-Leu-Phe-d-Leu-Phe-OH

(2014) Ryo Hayashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, Synthesis and Characterization of fMLF-Mimicking AApeptides

(2014) Yaogang Hu  et al.   CHEMBIOCHEM

Development of Small Molecule Non-peptide Formyl Peptide Receptor (FPR) Ligands and Molecular Modeling of Their Recognition

(2014) I.A. Schepetkin et al.   CURRENT MEDICINAL CHEMISTRY

Serum amyloid A1 isoforms display different efficacy at Toll-like receptor 2 and formyl peptide receptor 2

(2014) Mingjie Chen et al.   IMMUNOBIOLOGY

Identification of Formyl Peptides from Listeria monocytogenes and Staphylococcus aureus as Potent Chemoattractants for Mouse Neutrophils

(2014) E. L. Southgate et al.   JOURNAL OF IMMUNOLOGY

Uteroglobin, a Possible Ligand of the Lipoxin Receptor Inhibits Serum Amyloid A-Driven Inflammation

(2014) Giovanni Antico et al.   MEDIATORS OF INFLAMMATION

Two Trypanocidal Dipeptides from the Roots of Zapoteca portoricensis (Fabaceae)

(2014) Ngozi Nwodo et al.   MOLECULES

A Pepducin Derived from the Third Intracellular Loop of FPR2 Is a Partial Agonist for Direct Activation of This Receptor in Neutrophils But a Full Agonist for Cross-Talk Triggered Reactivation of FPR2

(2014) Michael Gabl et al.   PLoS One

Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis

(2014) J. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidized low-density lipoprotein-induced foam cell formation is mediated by formyl peptide receptor 2

(2013) Ha Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heterologously expressed formyl peptide receptor 2 (FPR2/ALX) does not respond to lipoxin A4

(2013) Julien Hanson et al.   BIOCHEMICAL PHARMACOLOGY

The leukocyte chemotactic receptor FPR2, but not the closely related FPR1, is sensitive to cell-penetrating pepducins with amino acid sequences descending from the third intracellular receptor loop

(2013) Huamei Forsman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synthesis and Pharmacological Evaluation of New Pyridazin-Based Thioderivatives as Formyl Peptide Receptor (FPR) Agonists

(2013) Letizia Crocetti et al.   DRUG DEVELOPMENT RESEARCH

Further studies on 2-arylacetamide pyridazin-3(2H)-ones: Design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists

(2013) Maria Paola Giovannoni et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Insight into structure-function relationship in phenol-soluble modulins using an alanine screen of the phenol-soluble modulin (PSM) α3 peptide

(2013) Gordon Y. C. Cheung et al.   FASEB JOURNAL

Community-associated MRSA: What makes them special?

(2013) Michael Otto   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Distinct Signaling Cascades Elicited by Different Formyl Peptide Receptor 2 (FPR2) Agonists

(2013) Fabio Cattaneo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Determinants for the Interaction of Formyl Peptide Receptor 2 with Peptide Ligands

(2013) Hui-Qiong He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioactive Secondary Metabolites of a Marine Bacillus sp. Inhibit Superoxide Generation and Elastase Release in Human Neutrophils by Blocking Formyl Peptide Receptor 1

(2013) Shun-Chin Yang et al.   MOLECULES

Design and synthesis of tryptophan containing dipeptide derivatives as formyl peptide receptor 1 antagonist

(2013) Tsong-Long Hwang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Endogenous Acute Phase Serum Amyloid A Lacks Pro-Inflammatory Activity, Contrasting the Two Recombinant Variants That Activate Human Neutrophils through Different Receptors

(2013) Karin Christenson et al.   Frontiers in Immunology

Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation

(2012) Olutayo Odusanwo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Genetic Ablation of theFpr1Gene Confers Protection from Smoking-Induced Lung Emphysema in Mice

(2012) Silvia Cardini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR 1

(2012) Hülya Çevik-Aras et al.   BIOCHEMICAL PHARMACOLOGY

3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2

(2012) Igor A. Schepetkin et al.   BIOCHEMICAL PHARMACOLOGY

Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists

(2012) Agostino Cilibrizzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Receptor-Dependent and -Independent Immunomodulatory Effects of Phenol-Soluble Modulin Peptides from Staphylococcus aureus on Human Neutrophils Are Abrogated through Peptide Inactivation by Reactive Oxygen Species

(2012) Huamei Forsman et al.   INFECTION AND IMMUNITY

Apolipoproteins and Apolipoprotein Mimetic Peptides Modulate Phagocyte Trafficking through Chemotactic Activity

(2012) Jennifer H. Madenspacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Turning Receptors On and Off with Intracellular Pepducins: New Insights into G-protein-coupled Receptor Drug Development

(2012) Katie O'Callaghan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin A1 Interaction with the FPR2/ALX Receptor

(2012) Stefania Bena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

(2012) J. Claria et al.   JOURNAL OF IMMUNOLOGY

Structural Characterization and Inhibitory Profile of Formyl Peptide Receptor 2 Selective Peptides Descending from a PIP2-Binding Domain of Gelsolin

(2012) H. Forsman et al.   JOURNAL OF IMMUNOLOGY

Leukocyte chemoattractant receptor FPR2 may accelerate atherogenesis

(2012) Wuzhou Wan et al.   MEDICAL HYPOTHESES

Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injury

(2012) O Eickmeier et al.   Mucosal Immunology

The Role of Water in Activation Mechanism of Human N-Formyl Peptide Receptor 1 (FPR1) Based on Molecular Dynamics Simulations

(2012) Shuguang Yuan et al.   PLoS One

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

(2012) F. A. Pamplona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

(2012) S. Bozinovski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes

(2012) Mingyong Liu et al.   Scientific Reports

Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury

(2011) Min He et al.   ACTA PHARMACOLOGICA SINICA

Stimulation of human formyl peptide receptors by calpain inhibitors: Homology modeling of receptors and ligand docking simulation

(2011) Hisakazu Fujita et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Reduced Fear Memory and Anxiety-like Behavior in Mice Lacking Formylpeptide Receptor 1

(2011) Ji-Liang Gao et al.   BEHAVIOR GENETICS

Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1

(2011) Min Wan et al.   FASEB JOURNAL

Lipoxin A4 is a novel estrogen receptor modulator

(2011) Ronan Russell et al.   FASEB JOURNAL

Characterization of Fpr-rs8, an Atypical Member of the Mouse Formyl Peptide Receptor Gene Family

(2011) H. Lee Tiffany et al.   Journal of Innate Immunity

Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1

(2011) Andrei I. Khlebnikov et al.   JOURNAL OF MOLECULAR MODELING

What Formyl Peptide Receptors, if Any, Are Triggered by Compound 43 and Lipoxin A4 ?

(2011) H. Forsman et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1

(2010) Tetsuo Seki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation

(2010) Tsong-Long Hwang et al.   BIOCHEMICAL PHARMACOLOGY

Stable formyl peptide receptor agonists that activate the neutrophil NADPH-oxidase identified through screening of a compound library

(2010) Huamei Forsman et al.   BIOCHEMICAL PHARMACOLOGY

Human Formyl Peptide Receptor 2 Senses Highly Pathogenic Staphylococcus aureus

(2010) Dorothee Kretschmer et al.   Cell Host & Microbe

Activation of human monocytes by a formyl peptide receptor 2-derived pepducin

(2010) Ha Young Lee et al.   FEBS LETTERS

The Annexin I Sequence Gln9-Ala10-Trp11-Phe12Is a Core Structure for Interaction with the Formyl Peptide Receptor 1

(2010) Charlotta Movitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The expression of β-defensin-2, 3 and LL-37 induced by Candida albicans phospholipomannan in human keratinocytes

(2010) Min Li et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Formyl Peptide Receptor 1 and 2 Dual Agonist Inhibits Human Neutrophil Chemotaxis by the Induction of Chemoattractant Receptor Cross-desensitization

(2010) Yoshitaka Sogawa et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Formyl peptide receptor-mediated proinflammatory consequences of peptide deformylase inhibition in Staphylococcus aureus

(2010) Diana Mader et al.   MICROBES AND INFECTION

Gastrin-Releasing Peptide/Neuromedin B Receptor Antagonists PD176252, PD168368, and Related Analogs Are Potent Agonists of Human Formyl-Peptide Receptors

(2010) I. A. Schepetkin et al.   MOLECULAR PHARMACOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

(2010) Michael P. Bokoch et al.   NATURE

Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids

(2010) Mariantonella Colucci et al.   PEPTIDES

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Insider access: pepducin symposium explores a new approach to GPCR modulation

(2009) Jacquelyn Miller et al.   Annals of the New York Academy of Sciences

LL-37 inhibits serum amyloid A-induced IL-8 production in human neutrophils

(2009) Ha Young Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

A Novel Neutrophil-Specific PET Imaging Agent: cFLFLFK-PEG-64Cu

(2009) L. W. Locke et al.   JOURNAL OF NUCLEAR MEDICINE

Leucine Leucine-37 Uses Formyl Peptide Receptor-Like 1 to Activate Signal Transduction Pathways, Stimulate Oncogenic Gene Expression, and Enhance the Invasiveness of Ovarian Cancer Cells

(2009) S. B. Coffelt et al.   MOLECULAR CANCER RESEARCH

Identification of Novel Small-Molecule Agonists for Human Formyl Peptide Receptors and Pharmacophore Models of Their Recognition

(2009) L. N. Kirpotina et al.   MOLECULAR PHARMACOLOGY

Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors

(2009) Stéphane Rivière et al.   NATURE

International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the Formyl Peptide Receptor (FPR) Family

(2009) R. D. Ye et al.   PHARMACOLOGICAL REVIEWS

Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ

(2009) S. D. Liberles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells

(2009) S. B. Coffelt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoxin A4Metabolites/Analogues from Two Commercial Sources have No Effects on TNF-α-mediated Priming or Activation through the Neutrophil Formyl Peptide Receptors

(2009) H. Forsman et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Mycobacteria Attenuate Nociceptive Responses by Formyl Peptide Receptor Triggered Opioid Peptide Release from Neutrophils

(2009) Heike L. Rittner et al.   PLoS Pathogens

FPRL1-mediated induction of superoxide in LL-37-stimulated IMR90 human fibroblast

(2008) Annalisa Iaccio et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes

(2008) Susan M. Young et al.   CYTOMETRY PART A

A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand

(2008) J. Jacob Strouse et al.   CYTOMETRY PART A

Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents

(2008) Chiao-Ting Yen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

VIP differentially activates  2 integrins, CR1, and matrix metalloproteinase-9 in human monocytes through cAMP/PKA, EPAC, and PI-3K signaling pathways via VIP receptor type 1 and FPRL1

(2008) N. El Zein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Novel Peptide Agonist of Formyl-Peptide Receptor-Like 1 (ALX) Displays Anti-Inflammatory and Cardioprotective Effects

(2008) I. Hecht et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Identification of Novel Formyl Peptide Receptor-Like 1 Agonists That Induce Macrophage Tumor Necrosis Factor   Production

(2008) I. A. Schepetkin et al.   MOLECULAR PHARMACOLOGY

(2R,3R)-2-(3′,4′-dihydroxybenzyl)-3-(3″,4″-dimethoxybenzyl)butyrolactone suppresses fMLP-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils

(2007) Yi-Jia Huang et al.   BIOCHEMICAL PHARMACOLOGY