The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy

Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging

(2021) Liam C. Hunt et al.   Nature Communications

Discovery of Thymosin Beta-4 as a Human Exerkine and Growth Factor

(2021) Alba Gonzalez-Franquesa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models

(2021) Mengyuan Niu et al.   Cell Death & Disease

A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila

(2021) Flavia A. Graca et al.   PLoS Genetics

Interleukin‐4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma‐bearing mice

(2020) Domiziana Costamagna et al.   Journal of Cachexia Sarcopenia and Muscle

Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice

(2020) Rowena Suriben et al.   NATURE MEDICINE

FIBCD1 ameliorates weight loss in chemotherapy-induced murine mucositis

(2020) Maria C. E. Andersen et al.   SUPPORTIVE CARE IN CANCER

The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia

(2020) Brandon N. VanderVeen et al.   Frontiers in Physiology

Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation

(2019) Wei Song et al.   DEVELOPMENTAL CELL

Exercise-Induced Myokines With Therapeutic Potential for Muscle Wasting

(2019) Rosanna Piccirillo   Frontiers in Physiology

Role of Myokines in Regulating Skeletal Muscle Mass and Function

(2019) Jong Han Lee et al.   Frontiers in Physiology

Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas

(2019) Scott Newman et al.   NATURE MEDICINE

Regular aerobic exercise-ameliorated troponin I carbonylation to mitigate aged rat soleus muscle functional recession

(2019) Wenfeng Liu et al.   EXPERIMENTAL PHYSIOLOGY

Identification of potential target genes associated with the reversion of androgen-dependent skeletal muscle atrophy

(2019) Priscila de O. Coelho et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

COL4A1 Mutations Cause Neuromuscular Disease with Tissue-Specific Mechanistic Heterogeneity

(2019) Cassandre Labelle-Dumais et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Skeletal muscle mass loss and dose‐limiting toxicities in metastatic colorectal cancer patients

(2019) Sophie Kurk et al.   Journal of Cachexia Sarcopenia and Muscle

The tumor cell‐secreted matricellular protein WISP 1 drives pro‐metastatic collagen linearization

(2019) Hong Jia et al.   EMBO JOURNAL

Arrdc2 and Arrdc3 elicit divergent changes in gene expression in skeletal muscle following anabolic and catabolic stimuli

(2019) Bradley S. Gordon et al.   PHYSIOLOGICAL GENOMICS

A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice

(2019) Liam C. Hunt et al.   Cell Reports

Pathologic Characteristics of Spitz Melanoma With MAP3K8 Fusion or Truncation in a Pediatric Cohort

(2019) Scott Newman et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Modeling Human Cancer-induced Cachexia

(2019) Erin E. Talbert et al.   Cell Reports

Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

(2019) Jesper B. Moeller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice

(2019) Andrea D. Re Cecconi et al.   Cancers

Overexpression of FIBCD1 Is Predictive of Poor Prognosis in Gastric Cancer

(2018) Chunyi Jiang et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Effects of inspiratory muscle training in COPD patients: A systematic review and meta-analysis

(2018) Marc Beaumont et al.   Clinical Respiratory Journal

Development and Function of theDrosophilaTracheal System

(2018) Shigeo Hayashi et al.   GENETICS

Diaphragm Plasticity in Aging and Disease: Therapies for Muscle Weakness go from Strength to Strength

(2018) Sarah M. Greising et al.   JOURNAL OF APPLIED PHYSIOLOGY

Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle

(2018) Gang Wang et al.   NATURE MEDICINE

Development and Function of theDrosophilaTracheal System

(2018) Shigeo Hayashi et al.   GENETICS

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice

(2018) Lisa M. Walter et al.   EBioMedicine

The exerkine apelin reverses age-associated sarcopenia

(2018) Claire Vinel et al.   NATURE MEDICINE

Inter-tissue communication in cancer cachexia

(2018) Josep M. Argilés et al.   Nature Reviews Endocrinology

Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice

(2018) Jacob L. Brown et al.   Journal of Cachexia Sarcopenia and Muscle

Myokines as Possible Therapeutic Targets in Cancer Cachexia

(2018) Emilia Manole et al.   Journal of Immunology Research

Critical illness-associated diaphragm weakness

(2017) Martin Dres et al.   INTENSIVE CARE MEDICINE

Muscle damage and inflammation during recovery from exercise

(2017) Jonathan M. Peake et al.   JOURNAL OF APPLIED PHYSIOLOGY

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

(2017) Bérengère Benoit et al.   NATURE MEDICINE

Pathology and genomics of pediatric melanoma: A critical reexamination and new insights

(2017) Armita Bahrami et al.   PEDIATRIC BLOOD & CANCER

Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

(2017) Musarrat Maisha Reza et al.   Nature Communications

Toll-like receptor 4 mediates Lewis lung carcinoma-induced muscle wasting via coordinate activation of protein degradation pathways

(2017) Guohua Zhang et al.   Scientific Reports

Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise

(2017) Adeel Safdar et al.   Cold Spring Harbor Perspectives in Medicine

Janus kinase inhibition prevents cancer- and myocardial infarction-mediated diaphragm muscle weakness in mice

(2016) Ira J. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

(2016) Mamta Rai et al.   Annual Review of Physiology

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer

(2016) Serkan Kir et al.   Cell Metabolism

The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities

(2016) Elizabeth Stewart et al.   DEVELOPMENTAL BIOLOGY

Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice

(2016) Andoria Tjondrokoesoemo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotypic and metabolic features of mouse diaphragm and gastrocnemius muscles in chronic lung carcinogenesis: influence of underlying emphysema

(2016) Anna Salazar-Degracia et al.   Journal of Translational Medicine

Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities

(2016) Erin E. Talbert et al.   MOLECULAR CANCER THERAPEUTICS

Functional impact of sarcopenia in respiratory muscles

(2016) Jonathan E. Elliott et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

(2016) Catherine E. Winbanks et al.   Science Translational Medicine

Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia

(2016) Daniel Delitto et al.   Oncotarget

Conditional Loss of Pten in Myogenic Progenitors Leads to Postnatal Skeletal Muscle Hypertrophy but Age-Dependent Exhaustion of Satellite Cells

(2016) Feng Yue et al.   Cell Reports

Dysfunction of respiratory muscles in critically ill patients on the intensive care unit

(2016) David Berger et al.   Journal of Cachexia Sarcopenia and Muscle

Po2 cycling protects diaphragm function during reoxygenation via ROS, Akt, ERK, and mitochondrial channels

(2015) Li Zuo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients

(2015) Pleuni E. Hooijman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation

(2015) P. Dinarvand et al.   BLOOD

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival

(2015) Amelia J. Johnston et al.   CELL

The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling

(2015) Liam C. Hunt et al.   GENES & DEVELOPMENT

Secretome Analysis of Lipid-Induced Insulin Resistance in Skeletal Muscle Cells by a Combined Experimental and Bioinformatics Workflow

(2015) Atul S. Deshmukh et al.   JOURNAL OF PROTEOME RESEARCH

Muscle-Derived Extracellular Signal-Regulated Kinases 1 and 2 Are Required for the Maintenance of Adult Myofibers and Their Neuromuscular Junctions

(2015) Bonnie Seaberg et al.   MOLECULAR AND CELLULAR BIOLOGY

The complex liaison between cachexia and tumor burden (Review)

(2015) ANDREA DE LERMA BARBARO   ONCOLOGY REPORTS

Cancer cachexia causes skeletal muscle damage via transient receptor potential vanilloid 2-independent mechanisms, unlike muscular dystrophy

(2015) Yuko Iwata et al.   Journal of Cachexia Sarcopenia and Muscle

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

(2014) Sue C. Bodine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

REDD1 deletion prevents dexamethasone-induced skeletal muscle atrophy

(2014) Florian A. Britto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The myokine decorin is regulated by contraction and involved in muscle hypertrophy

(2014) Timo Kanzleiter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Resveratrol prevents TNF-α-induced muscle atrophy via regulation of Akt/mTOR/FoxO1 signaling in C2C12 myotubes

(2014) Dong-Tao Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

(2014) Serkan Kir et al.   NATURE

Platelets guide the formation of early metastatic niches

(2014) M. Labelle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intertissue Control of the Nucleolus via a Myokine-Dependent Longevity Pathway

(2014) Fabio Demontis et al.   Cell Reports

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

(2013) Nicolas J. Pillon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Towards a simple objective framework for the investigation and treatment of cancer cachexia: The Glasgow Prognostic Score

(2013) Euan Douglas et al.   CANCER TREATMENT REVIEWS

Mechanisms of muscle growth and atrophy in mammals andDrosophila

(2013) Rosanna Piccirillo et al.   DEVELOPMENTAL DYNAMICS

Diaphragm muscle sarcopenia in aging mice

(2013) Sarah M. Greising et al.   EXPERIMENTAL GERONTOLOGY

Diaphragm and ventilatory dysfunction during cancer cachexia

(2013) Brandon M. Roberts et al.   FASEB JOURNAL

Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia

(2013) Melissa J. Puppa et al.   FASEB JOURNAL

Loss of sparc in mouse skeletal muscle causes myofiber atrophy

(2013) Katsuyuki Nakamura et al.   MUSCLE & NERVE

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders

(2013) Rosamund C. Smith et al.   Current Opinion in Supportive and Palliative Care

Rel A/p65 is required for cytokine-induced myotube atrophy

(2012) Takuo Yamaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

(2012) Jorge L. Ruas et al.   CELL

Srf-Dependent Paracrine Signals Produced by Myofibers Control Satellite Cell-Mediated Skeletal Muscle Hypertrophy

(2012) Aline Guerci et al.   Cell Metabolism

Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways

(2012) Kenneth C.H. Fearon et al.   Cell Metabolism

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Myostatin: more than just a regulator of muscle mass

(2012) Josep M. Argilés et al.   DRUG DISCOVERY TODAY

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Rapid Determination of Myosin Heavy Chain Expression in Rat, Mouse, and Human Skeletal Muscle Using Multicolor Immunofluorescence Analysis

(2012) Darin Bloemberg et al.   PLoS One

Cancer cachexia: malignant inflammation, tumorkines, and metabolic mayhem

(2012) Maria Tsoli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Zbtb16 has a role in brown adipocyte bioenergetics

(2012) C L Plaisier et al.   Nutrition & Diabetes

Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training

(2011) Frode Norheim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice

(2011) Kate T. Murphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Endogenous Bmp4 in myoblasts is required for myotube formation in C2C12 cells

(2011) Takenao Umemoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An integrative approach to ortholog prediction for disease-focused and other functional studies

(2011) Yanhui Hu et al.   BMC BIOINFORMATICS

Targeting Protein Synthesis in a Myc/mTOR-Driven Model of Anorexia-Cachexia Syndrome Delays Its Onset and Prolongs Survival

(2011) F. Robert et al.   CANCER RESEARCH

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

(2011) Noriaki Shimizu et al.   Cell Metabolism

LIF is a contraction-induced myokine stimulating human myocyte proliferation

(2011) Christa Broholm et al.   JOURNAL OF APPLIED PHYSIOLOGY

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

(2011) Andrea Bonetto et al.   PLoS One

Relaxin Regulates MMP Expression and Promotes Satellite Cell Mobilization During Muscle Healing in Both Young and Aged Mice

(2010) Xiaodong Mu et al.   AMERICAN JOURNAL OF PATHOLOGY

Intracellular signaling pathways regulating net protein balance following diaphragm muscle denervation

(2010) Heather M. Argadine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dynamic Regulation of Fibrinogen: Integrin αIIbβ3 Binding

(2010) Roy R. Hantgan et al.   BIOCHEMISTRY

Reversing Cachexia

(2010) Michael J. Tisdale   CELL

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Signaling pathways perturbing muscle mass

(2010) David J Glass   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor

(2010) Ling Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitogen-activated protein kinase signaling is necessary for the maintenance of skeletal muscle mass

(2009) Hao Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Integration of Insulin receptor/Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila

(2009) F. Demontis et al.   DEVELOPMENT

Characterization of FIBCD1 as an Acetyl Group-Binding Receptor That Binds Chitin

(2009) A. Schlosser et al.   JOURNAL OF IMMUNOLOGY

Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy

(2008) Antonio L. Serrano et al.   Cell Metabolism

The extracellular matrix protein TGFBI promotes myofibril bundling and muscle fibre growth in the zebrafish embryo

(2008) H. Rosemary Kim et al.   DEVELOPMENTAL DYNAMICS

Nebulin Interacts with CapZ and Regulates Thin Filament Architecture within the Z-Disc

(2008) Christopher T. Pappas et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL