Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients

Unaffected contractility of diaphragm muscle fibers in humans on mechanical ventilation

(2014) Pleuni E. Hooijman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Diaphragm Fiber Strength Is Reduced in Critically Ill Patients and Restored by a Troponin Activator

(2014) Pleuni E. Hooijman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of Controlled Mechanical Ventilation on Sepsis-Induced Diaphragm Dysfunction in Rats

(2014) Karen Maes et al.   CRITICAL CARE MEDICINE

Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness

(2014) Tobias Wollersheim et al.   INTENSIVE CARE MEDICINE

Diaphragm Dysfunction on Admission to the Intensive Care Unit. Prevalence, Risk Factors, and Prognostic Impact—A Prospective Study

(2013) Alexandre Demoule et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

(2013) Marco Sandri   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Muscle Injury During Critical Illness

(2013) Jane Batt et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Acute Skeletal Muscle Wasting in Critical Illness

(2013) Zudin A. Puthucheary et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Diaphragm ultrasound as a predictor of successful extubation from mechanical ventilation

(2013) Ernest DiNino et al.   THORAX

Rapid Onset of Specific Diaphragm Weakness in a Healthy Murine Model of Ventilator-induced Diaphragmatic Dysfunction

(2012) Segolene Mrozek et al.   ANESTHESIOLOGY

Diaphragm Muscle Thinning in Patients Who Are Mechanically Ventilated

(2012) Horiana B. Grosu et al.   CHEST

Bortezomib partially protects the rat diaphragm from ventilator-induced diaphragm dysfunction*

(2012) Anouk Agten et al.   CRITICAL CARE MEDICINE

Cellular and molecular mechanisms of muscle atrophy

(2012) P. Bonaldo et al.   Disease Models & Mechanisms

Proteasome inhibition improves diaphragm function in an animal model for COPD

(2011) Hieronymus van Hees et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Calcium Sensitizer Levosimendan Improves Human Diaphragm Function

(2011) Jonne Doorduin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Selective Diaphragm Muscle Weakness After Contractile Inactivity During Thoracic Surgery

(2011) Willem N. Welvaart et al.   ANNALS OF SURGERY

The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice

(2011) Annabelle Z Caron et al.   BMC MUSCULOSKELETAL DISORDERS

A potential selection bias in the study of early combination antibiotic therapy versus monotherapy in septic shock

(2011) Dae Hyun Kim   CRITICAL CARE MEDICINE

Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy

(2011) C. A. C. Ottenheijm et al.   HUMAN MOLECULAR GENETICS

Identification of prolonged phrenic nerve conduction time in the ICU: magnetic versus electrical stimulation

(2011) Alexandre Demoule et al.   INTENSIVE CARE MEDICINE

Prevention of muscle disuse atrophy by MG132 proteasome inhibitor

(2011) Cecile Jamart et al.   MUSCLE & NERVE

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

(2011) Margaret S. Herridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy

(2010) Sabah N. A. Hussain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

(2010) Sanford Levine et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension

(2010) Frances S. de Man et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rapidly Progressive Diaphragmatic Weakness and Injury during Mechanical Ventilation in Humans

(2010) Samir Jaber et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prolonged mechanical ventilation alters diaphragmatic structure and function

(2010) Scott K. Powers et al.   CRITICAL CARE MEDICINE

Inhibition of Atrogin-1/MAFbx Expression by Adenovirus-Delivered Small Hairpin RNAs Attenuates Muscle Atrophy in Fasting Mice

(2010) Haolong Cong et al.   HUMAN GENE THERAPY

Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm

(2010) Melissa A. Whidden et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction

(2009) G. S. Supinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency

(2009) C. A.C. Ottenheijm et al.   HUMAN MOLECULAR GENETICS

Levosimendan Enhances Force Generation of Diaphragm Muscle from Patients with Chronic Obstructive Pulmonary Disease

(2008) Hieronymus W. H. van Hees et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

(2008) Sanford Levine et al.   NEW ENGLAND JOURNAL OF MEDICINE