Elimination of Fusarium mycotoxin deoxynivalenol (DON) via microbial and enzymatic strategies: Current status and future perspectives

A quinoprotein dehydrogenase from Pelagibacterium halotolerans ANSP101 oxidizes deoxynivalenol to 3-keto-deoxynivalenol

(2022) Xiaojuan Qin et al.   FOOD CONTROL

Crystal structure and biochemical analysis of the specialized deoxynivalenol–detoxifying glyoxalase SPG from Gossypium hirsutum

(2022) Yumei Hu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Enzyme Promiscuity Prediction Using Hierarchy-Informed Multi-Label Classification

(2021) Gian Marco Visani et al.   BIOINFORMATICS

Possibilities for the Biological Control of Mycotoxins in Food and Feed

(2021) Ksenija Nešić et al.   Toxins

Mechanisms of deoxynivalenol (DON) degradation during different treatments: a review

(2021) Ehsan Feizollahi et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Biomarkers of deoxynivalenol (DON) and its modified form DON-3-glucoside (DON-3G) in humans

(2021) Ying Deng et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Maize food chain and mycotoxins: A review on occurrence studies

(2021) Marta Leite et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Bacterial Enrichment Cultures Biotransform the Mycotoxin Deoxynivalenol into a Novel Metabolite Toxic to Plant and Porcine Cells

(2021) Ilse Vanhoutte et al.   Toxins

Biodegradation of Deoxynivalenol by Nocardioides sp. ZHH-013: 3-keto-Deoxynivalenol and 3-epi-Deoxynivalenol as Intermediate Products

(2021) Honghai Zhang et al.   Frontiers in Microbiology

Post-translational regulation of autophagy is involved in intra-microbiome suppression of fungal pathogens

(2021) Jing Wang et al.   Microbiome

Deoxynivalenol: Masked forms, fate during food processing, and potential biological remedies

(2020) Hongyan Guo et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Transcriptomic and exometabolomic profiling reveals antagonistic and defensive modes of Clonostachys rosea action against Fusarium graminearum

(2020) Zerihun A Demissie et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Aromatization of natural products by a specialized detoxification enzyme

(2020) Jin-Quan Huang et al.   Nature Chemical Biology

Metabolomics-guided analysis reveals a two-step epimerization of deoxynivalenol catalyzed by the bacterial consortium IFSN-C1

(2020) Gang Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

TransformerCPI: Improving compound–protein interaction prediction by sequence-based deep learning with self-attention mechanism and label reversal experiments

(2020) Lifan Chen et al.   BIOINFORMATICS

Improving the accuracy of protein thermostability predictions for single point mutations - Effects of unfolded states and methods for proline mutations

(2020) Jianxin Duan et al.   BIOPHYSICAL JOURNAL

Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies

(2020) Liesel Claeys et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

From laboratory to the field: biological control of Fusarium graminearum on infected maize crop residues

(2020) A. Gimeno et al.   JOURNAL OF APPLIED MICROBIOLOGY

Molecular docking studies and in vitro degradation of four aflatoxins (AFB 1 , AFB 2 , AFG 1 , and AFG 2 ) by a recombinant laccase from Saccharomyces cerevisiae

(2020) Yingli Liu et al.   JOURNAL OF FOOD SCIENCE

Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat

(2020) Hongwei Wang et al.   SCIENCE

Isolation and Characterization of a Deoxynivalenol-Degrading Bacterium Bacillus licheniformis YB9 with the Capability of Modulating Intestinal Microbial Flora of Mice

(2020) Shiwei Wang et al.   Toxins

An In Silico Target Fishing Approach to Identify Novel Ochratoxin A Hydrolyzing Enzyme

(2020) Luca Dellafiora et al.   Toxins

MONN: A Multi-objective Neural Network for Predicting Compound-Protein Interactions and Affinities

(2020) Shuya Li et al.   Cell Systems

Deep Docking: A Deep Learning Platform for Augmentation of Structure Based Drug Discovery

(2020) Francesco Gentile et al.   ACS Central Science

Application of ozone for degradation of mycotoxins in food: A review

(2020) Leili Afsah‐Hejri et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Enzymatic degradation of deoxynivalenol by a novel bacterium, Pelagibacterium halotolerans ANSP101

(2020) Jing Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

A quinone-dependent dehydrogenase and two NADPH-dependent aldo/keto reductases detoxify deoxynivalenol in wheat via epimerization in a Devosia strain

(2020) Wei-Jie He et al.   FOOD CHEMISTRY

Improving Enzyme Optimum Temperature Prediction with Resampling Strategies and Ensemble Learning

(2020) Japheth E. Gado et al.   Journal of Chemical Information and Modeling

A systematic review and meta-analysis to investigate the concentration and prevalence of trichothecenes in the cereal-based food

(2020) Amin Mousavi Khaneghah et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Novel Soil Bacterium Strain Desulfitobacterium sp. PGC-3-9 Detoxifies Trichothecene Mycotoxins in Wheat via De-Epoxidation under Aerobic and Anaerobic Conditions

(2020) Wei-Jie He et al.   Toxins

Trichoderma: The “Secrets” of a Multitalented Biocontrol Agent

(2020) Monika Sood et al.   Plants-Basel

Sarocladium zeae is a systemic endophyte of wheat and an effective biocontrol agent against Fusarium head blight

(2020) Nathan D. Kemp et al.   BIOLOGICAL CONTROL

Machine learning for chemical discovery

(2020) Alexandre Tkatchenko   Nature Communications

TaUGT6, a Novel UDP-Glycosyltransferase Gene Enhances the Resistance to FHB and DON Accumulation in Wheat

(2020) Yi He et al.   Frontiers in Plant Science

Plant Cell Wall Changes in Common Wheat Roots as a Result of Their Interaction with Beneficial Fungi of Trichoderma

(2020) Aneta Basińska-Barczak et al.   Cells

Regulation Efficacy and Mechanism of the Toxicity of Microcystin-LR Targeting Protein Phosphatase 1 via the Biodegradation Pathway

(2020) Luyao Ren et al.   Toxins

Is Exploitation Competition Involved in a Multitrophic Strategy for the Biocontrol of Fusarium Head Blight?

(2019) Sabrina Sarrocco et al.   PHYTOPATHOLOGY

Global occurrence of deoxynivalenol in food commodities and exposure risk assessment in humans in the last decade: a survey

(2019) Sakshi Mishra et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Fusarium graminearum Trichothecene Mycotoxins: Biosynthesis, Regulation, and Management

(2019) Yun Chen et al.   Annual Review of Phytopathology

Fengycin Produced by Bacillus amyloliquefaciens FZB42 Inhibits Fusarium graminearum Growth and Mycotoxins Biosynthesis

(2019) Alvina Hanif et al.   Toxins

Deep learning enables high-quality and high-throughput prediction of enzyme commission numbers

(2019) Jae Yong Ryu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EnzyDock: Protein–Ligand Docking of Multiple Reactive States along a Reaction Coordinate in Enzymes

(2019) Susanta Das et al.   Journal of Chemical Theory and Computation

Detoxification of Deoxynivalenol by a Mixed Culture of Soil Bacteria With 3-epi-Deoxynivalenol as the Main Intermediate

(2019) Yaoyao Zhai et al.   Frontiers in Microbiology

Convolution Neural Network-Based Prediction of Protein Thermostability

(2019) Xingrong Fang et al.   Journal of Chemical Information and Modeling

ACID: a free tool for drug repurposing using consensus inverse docking strategy

(2019) Fan Wang et al.   Journal of Cheminformatics

Selection of an Endophytic Streptomyces sp. Strain DEF09 From Wheat Roots as a Biocontrol Agent Against Fusarium graminearum

(2019) Elena Maria Colombo et al.   Frontiers in Microbiology

Recent advances on toxicity and determination methods of mycotoxins in foodstuffs

(2019) Yan Yang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Machine Learning in Enzyme Engineering

(2019) Stanislav Mazurenko et al.   ACS Catalysis

Compound-protein Interaction Prediction with End-to-end Learning of Neural Networks for Graphs and Sequences

(2018) Masashi Tsubaki et al.   BIOINFORMATICS

Effects and biotransformation of the mycotoxin deoxynivalenol in growing pigs fed with naturally contaminated pelleted grains with and without the addition of Coriobacteriaceum DSM 11798

(2018) Amin Sayyari et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9

(2018) Xiaojuan Gao et al.   FOOD AND CHEMICAL TOXICOLOGY

The Identification of DepB: An Enzyme Responsible for the Final Detoxification Step in the Deoxynivalenol Epimerization Pathway in Devosia mutans 17-2-E-8

(2018) Jason Carere et al.   Frontiers in Microbiology

Screening of new bacterial isolates with antifungal activity and application of selected Bacillus sp. cultures for biocontrol of Fusarium graminearum under field conditions

(2018) Karina Stumbriene et al.   CROP PROTECTION

Asymmetric biodegradation of the nerve agents Sarin and VX by human dUTPase: Chemometrics, Molecular Docking and Hybrid QM/MM calculations

(2018) Alexandre A. de Castro et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Wheat microbiome bacteria can reduce virulence of a plant pathogenic fungus by altering histone acetylation

(2018) Yun Chen et al.   Nature Communications

Comparative Assessment of Scoring Functions: The CASF-2016 Update

(2018) Minyi Su et al.   Journal of Chemical Information and Modeling

Food raw materials and food production occurrences of deoxynivalenol in different regions

(2018) Liangliang Wang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Biodegradation of deoxynivalenol and its derivatives by Devosia insulae A16

(2018) Gang Wang et al.   FOOD CHEMISTRY

A barley UDP-glucosyltransferase inactivates nivalenol and provides Fusarium Head Blight resistance in transgenic wheat

(2017) Xin Li et al.   JOURNAL OF EXPERIMENTAL BOTANY

Isolation and characterization of a novel deoxynivalenol-transforming strain Paradevosia shaoguanensis DDB001 from wheat field soil

(2017) Y. Wang et al.   LETTERS IN APPLIED MICROBIOLOGY

Integrated control of fusarium head blight and deoxynivalenol mycotoxin in wheat

(2017) L. Shah et al.   PLANT PATHOLOGY

Antioxidant agents against trichothecenes: new hints for oxidative stress treatment

(2017) Qinghua Wu et al.   Oncotarget

Effects of Adding Clostridium sp. WJ06 on Intestinal Morphology and Microbial Diversity of Growing Pigs Fed with Natural Deoxynivalenol Contaminated Wheat

(2017) FuChang Li et al.   Toxins

The enzymatic detoxification of the mycotoxin deoxynivalenol: identification of DepA from the DON epimerization pathway

(2017) Jason Carere et al.   Microbial Biotechnology

An aldo-keto reductase is responsible for Fusarium toxin-degrading activity in a soil Sphingomonas strain

(2017) Wei-Jie He et al.   Scientific Reports

Using reverse docking for target identification and its applications for drug discovery

(2016) Aeri Lee et al.   Expert Opinion on Drug Discovery

Boosting Docking-Based Virtual Screening with Deep Learning

(2016) Janaina Cruz Pereira et al.   Journal of Chemical Information and Modeling

A Brachypodium UDP-Glycosyltransferase Confers Root Tolerance to Deoxynivalenol and Resistance to Fusarium Infection

(2016) Jean-Claude Pasquet et al.   PLANT PHYSIOLOGY

Detoxification of Deoxynivalenol via Glycosylation Represents Novel Insights on Antagonistic Activities of Trichoderma when Confronted with Fusarium graminearum

(2016) Ye Tian et al.   Toxins

Aerobic De-Epoxydation of Trichothecene Mycotoxins by a Soil Bacterial Consortium Isolated Using In Situ Soil Enrichment

(2016) Wei-Jie He et al.   Toxins

Bacterial Epimerization as a Route for Deoxynivalenol Detoxification: the Influence of Growth and Environmental Conditions

(2016) Jian Wei He et al.   Frontiers in Microbiology

Functional Agents to Biologically Control Deoxynivalenol Contamination in Cereal Grains

(2016) Ye Tian et al.   Frontiers in Microbiology

Endophytic bacteria from wheat grain as biocontrol agents of Fusarium graminearum and deoxynivalenol production in wheat

(2015) D. Pan et al.   Mycotoxin Research

Transcriptomic characterization of two majorFusariumresistance quantitative trait loci (QTLs),Fhb1andQfhs.ifa-5A, identifies novel candidate genes

(2013) Wolfgang Schweiger et al.   MOLECULAR PLANT PATHOLOGY

Bacterial Cytochrome P450 System Catabolizing the Fusarium Toxin Deoxynivalenol

(2012) Michihiro Ito et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

FRED and HYBRID docking performance on standardized datasets

(2012) Mark McGann   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Biological detoxification of the mycotoxin deoxynivalenol and its use in genetically engineered crops and feed additives

(2011) Petr Karlovsky   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Efficacy of detoxification of deoxynivalenol-contaminated corn by Bacillus sp. LS100 in reducing the adverse effects of the mycotoxin on swine growth performance

(2011) X.-Z. Li et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Biocontrol of Fusarium head blight: interactions between Trichoderma and mycotoxigenic Fusarium

(2011) F. Matarese et al.   MICROBIOLOGY-SGM

Aerobic and anaerobic de-epoxydation of mycotoxin deoxynivalenol by bacteria originating from agricultural soil

(2011) Rafiqul Islam et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Nocardioides sp. strain WSN05-2, isolated from a wheat field, degrades deoxynivalenol, producing the novel intermediate 3-epi-deoxynivalenol

(2010) Yoko Ikunaga et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Decontamination and detoxification strategies for theFusariummycotoxin deoxynivalenol in animal feed and the effectiveness of microbial biodegradation

(2010) Wageha A. Awad et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Transformation of trichothecene mycotoxins by microorganisms from fish digesta

(2009) Shu Guan et al.   AQUACULTURE

Fusarium graminearum gene deletion mutants map1 and tri5 reveal similarities and differences in the pathogenicity requirements to cause disease on Arabidopsis and wheat floral tissue

(2008) Alayne Cuzick et al.   NEW PHYTOLOGIST