Article
Microbiology
Lina Zhang, Xishi Zhou, Pengfeng Li, Yiwei Wang, Qianyong Hu, Yuping Shang, Yunshen Chen, Xiying Zhu, Hongjie Feng, Cuijun Zhang
Summary: Fusarium graminearum is the main pathogen of Fusarium head blight (FHB) in wheat, barley, and corn. This study found that putrescine, a wheat defense compound, can have a significant impact on the transcriptome of F. graminearum and induce the synthesis of DON. Gene ontology and KEGG enrichment analysis revealed the involvement of various metabolic pathways. Co-expression analysis identified key transcription factor genes that may play important roles in DON synthesis. These findings provide important insights into the molecular mechanisms underlying putrescine-induced DON synthesis and facilitate the study of FHB pathogenic mechanisms.
Article
Microbiology
Izabela Podgorska-Kryszczuk, Ewa Solarska, Monika Kordowska-Wiater
Summary: Yeasts isolated from organic cereals showed strong inhibitory activity against Fusarium pathogens, with mechanisms including nutrient competition and inhibition of spore germination.
Article
Plant Sciences
Hannah Reed, Brian Mueller, Carol L. Groves, Damon L. Smith
Summary: Research shows that Fusarium graminearum and its toxic secondary metabolite DON accumulate in both stalks and ears of corn plants, with variations in contamination levels between different years and plant parts.
Article
Microbiology
Elias Alisaac, Anna Rathgeb, Petr Karlovsky, Anne-Katrin Mahlein
Summary: The study found that F. graminearum grows downward within infected wheat spikes and DON accumulation is largely confined to the colonized tissue. Additionally, F. graminearum was able to infect wheat kernels and cause mycotoxin contamination even when inoculated 25 days after anthesis.
Article
Food Science & Technology
Xingguang Chen, Beibei Chu, Qianhui Gu, Wenzhe Li, Rui Lin, Jiyang Chu, Zhengcong Peng, Jian Lu, Dianhui Wu
Summary: A protonated g-C3N4/oxygen-doped g-C3N4 composite was prepared and used to inhibit F. graminearum growth and DON accumulation in barley malt under visible light irradiation. The results showed that the inhibition rate of F. graminearum reached 100% after 2.5 h of visible light irradiation. The CNH/OCN composite material also had a significant photocatalytic inhibition effect on ergosterol and DON in malt.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Environmental Sciences
Chaofeng Li, Chenglan Liu
Summary: The fungicidal activity and enantioselective effect of prothioconazole enantiomers on DON production, transcriptome and metabolome of F. graminearum are studied in this research. The results indicate that R-(-)-prothioconazole has higher fungicidal activity and can induce F. graminearum to synthesize more DON compared to S-(+)-prothioconazole. The expression levels of several genes in different pathways are influenced by prothioconazole enantiomers treatment.
ENVIRONMENTAL POLLUTION
(2022)
Article
Agriculture, Multidisciplinary
Zongzhe He, Jing Zhang, Dongya Shi, Beibei Gao, Zhen Wang, Yanqing Zhang, Minghua Wang
Summary: The study revealed the stereoselective efficiency of Cyproconazole (CPZ) stereoisomers against Fusarium head blight (FHB), with RS-CPZ showing higher control efficacy and inhibiting deoxynivalenol production. This provides new insights into the mechanism of action of triazole fungicides against FHB and its toxins.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Microbiology
Guangfei Tang, Haoxue Xia, Jingting Liang, Zhonghua Ma, Wende Liu
Summary: The study revealed that deletion of spermidine biosynthesis gene FgSPE3 in Fusarium species caused growth defects, reduced reproduction, increased stress sensitivity, decreased mycotoxin production, and weakened virulence in host plants. Exogenous application of spermidine could rescue the growth and virulence defects, indicating that spermidine is essential for growth, development, mycotoxin production, and virulence in Fusarium species, presenting a potential target for controlling Fusarium head blight (FHB).
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Brian Mueller, Carol L. Groves, Damon L. Smith
Summary: This study examined the Fusarium population on wheat in Wisconsin and the chemotype profile of isolates from 2016 and 2017. The majority of isolates were identified as the 15ADON chemotype, with 3ADON making up 9%. 3ADON isolates in Wisconsin exhibited higher sporulation capacity, growth rate, and DON production, but showed no significant difference in aggressiveness compared to 15ADON isolates.
Article
Microbiology
Tao Gao, Yao Zhang, Jianrong Shi, Sherif Ramzy Mohamed, Jianhong Xu, Xin Liu
Summary: The main component of creosote, guaiacol, is a natural antioxidant that inhibits mycotoxins in Fusarium graminearum by damaging the cell membrane and modulating the oxidative response. The study found that guaiacol exerts inhibitory effects on mycelial growth, conidial formation, and deoxynivalenol biosynthesis in a dose-dependent manner, with the potential for pharmaceutical and food preservation applications.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Alfia Khairullina, Nikola Micic, Hans J. Lyngs Jorgensen, Nanna Bjarnholt, Leif Bulow, David B. Collinge, Birgit Jensen
Summary: The fungal biocontrol agent Clonostachys rosea is effective in reducing Fusarium graminearum DNA and DON toxin accumulation in oat, and can activate resistance-related gene expression. These findings suggest that C. rosea has potential as a biocontrol agent against Fusarium head blight in oat.
Article
Food Science & Technology
Adam Okorski, Alina Milewska, Agnieszka Pszczolkowska, Krzysztof Karpiesiuk, Wojciech Kozera, Joanna Agnieszka Dabrowska, Justyna Radwinska
Summary: Fusarium head blight (FHB) caused by fungi of the genus Fusarium is a severe crop disease that leads to significant economic losses in major cereal production. Different regions in Poland showed varied levels of contamination by Fusarium species, with warmer regions being colonized mainly by F. graminearum and high levels of deoxynivalenol (DON), while cooler regions had predominance of Fusarium species typical of cold climates. The severity of grain infection with certain Fusarium species was found to be affected by mean daily temperature and high humidity in May, with competitive interactions observed between different genotypes of Fusarium species.
Article
Plant Sciences
Gerit Bethke, Yadong Huang, Goetz Hensel, Shane Heinen, Chaochih Liu, Skylar R. Wyant, Xin Li, Maureen B. Quin, Susan Mccormick, Peter L. Morrell, Yanhong Dong, Jochen Kumlehn, Silvio Salvi, Franz Berthiller, Gary J. Muehlbauer
Summary: Through studying 496 barley accessions, it was found that the UGT13248 gene plays a role in resistance to Fusarium head blight (FHB) by converting DON to D3G, a nontoxic form; two mutant alleles (T368I and H369Y) were identified that increase FHB severity and reduce D3G production.
Article
Multidisciplinary Sciences
Fanlong Wang, Xianbi Li, Yujie Li, Jing Han, Yang Chen, Jianyan Zeng, Mei Su, Jingxin Zhuo, Hui Ren, Haoru Liu, Lei Hou, Yanhua Fan, Xingying Yan, Shuiqing Song, Juan Zhao, Dan Jin, Mi Zhang, Yan Pei
Summary: The Arabidopsis P4-ATPases AtALA1 and AtALA7 are found to detoxify mycotoxins by promoting vesicle transport, leading to their sequestration and degradation in vacuoles. Overexpression of AtALA1 and AtALA7 enhances plant resistance to Fusarium graminearum and Verticillium dahliae, while reducing the concentration of harmful mycotoxins in Arabidopsis siliques and maize seeds. This vesicle-mediated cell detoxification process offers a strategy to boost plant resistance against toxin-associated diseases and lower mycotoxin contamination in food and feed.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Sean P. O'Mara, Karen Broz, Erin M. Schwister, Lovepreet Singh, Yanhong Dong, J. Mitch Elmore, H. Corby Kistler
Summary: This study reveals that the deletion of membrane-bound transporters in the plant pathogenic fungus Fusarium graminearum leads to reduced accumulation of the mycotoxin deoxynivalenol (DON) and decreased disease symptoms on wheat. The ATP-binding cassette (ABC) transporter gene Abc1 plays a major role in DON accumulation and virulence reduction. Heterologous expression of F. graminearum transporters in yeast confirms Abc1 as a major mechanism of DON resistance and suggests the involvement of multiple transporters in resistance to other compounds. These findings provide valuable insights for developing novel management techniques for Fusarium head blight and other destructive plant diseases.
