A matter of time: temporal structure and functional relevance of macrophage metabolic rewiring

Itaconate confers tolerance to late NLRP3 inflammasome activation

(2021) Monika Bambouskova et al.   Cell Reports

Functions of ROS in Macrophages and Antimicrobial Immunity

(2021) Marc Herb et al.   Antioxidants

Complexity of macrophage metabolism in infection

(2021) Wei He et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mitochondrial metabolism regulates macrophage biology

(2021) Yafang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages

(2021) Seyeon Bae et al.   Cell Reports

Dynamic changes in macrophage metabolism modulate induction and suppression of Type I inflammatory responses

(2021) Haoming Luan et al.   CURRENT OPINION IN IMMUNOLOGY

Spatiotemporal proteomic profiling of the pro-inflammatory response to lipopolysaccharide in the THP-1 human leukaemia cell line

(2021) Claire M. Mulvey et al.   Nature Communications

Reactive Oxygen Species in Macrophages: Sources and Targets

(2021) Marcella Canton et al.   Frontiers in Immunology

Krebs Cycle Reborn in Macrophage Immunometabolism

(2020) Dylan G. Ryan et al.   Annual Review of Immunology

Metabolic Adaptations to Infections at the Organismal Level

(2020) Katia Troha et al.   TRENDS IN IMMUNOLOGY

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

(2020) Erika M. Palmieri et al.   Nature Communications

Cell‐intrinsic metabolic regulation of mononuclear phagocyte activation: Findings from the tip of the iceberg

(2020) Nikki Teijlingen Bakker et al.   IMMUNOLOGICAL REVIEWS

Cytokine-like Roles for Metabolites in Immunity

(2020) Zbigniew Zasłona et al.   MOLECULAR CELL

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

(2020) Alexander Hooftman et al.   Cell Metabolism

Metabolic regulation of epigenetic remodeling in immune cells

(2020) Emily C Britt et al.   CURRENT OPINION IN BIOTECHNOLOGY

Chemoproteomic Profiling of Itaconation by Bioorthogonal Probes in Inflammatory Macrophages

(2020) Wei Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging

(2020) Allison K. Meyers et al.   Cells

Triacylglycerol synthesis enhances macrophage inflammatory function

(2020) Angela Castoldi et al.   Nature Communications

Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight

(2020) Erika M. Palmieri et al.   Metabolites

The Intersection of Epigenetics and Metabolism in Trained Immunity

(2020) Stephanie Fanucchi et al.   IMMUNITY

Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation

(2020) Grzegorz Krzak et al.   TRENDS IN IMMUNOLOGY

Malonylation of GAPDH is an inflammatory signal in macrophages

(2019) Silvia Galván-Peña et al.   Nature Communications

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

(2019) Alanna M. Cameron et al.   NATURE IMMUNOLOGY

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

(2019) Kirthana Ganeshan et al.   CELL

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production

(2019) Elsa Sanchez-Lopez et al.   Cell Metabolism

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

(2019) Jade D. Bailey et al.   Cell Reports

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

(2019) Weiwei Yu et al.   MOLECULAR CELL

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses

(2019) P. Kent Langston et al.   NATURE IMMUNOLOGY

HIF-1α as a central mediator of cellular resistance to intracellular pathogens

(2019) Matthew Knight et al.   CURRENT OPINION IN IMMUNOLOGY

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Comparative Transcriptomic Response of Primary and Immortalized Macrophages to Murine Norovirus Infection

(2018) Eric A. Levenson et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptors Drive Specific Patterns of Tolerance and Training on Restimulation of Macrophages

(2018) Suzanne K. Butcher et al.   Frontiers in Immunology

High-Resolution Mapping and Dynamics of the Transcriptome, Transcription Factors, and Transcription Co-Factor Networks in Classically and Alternatively Activated Macrophages

(2018) Amitabh Das et al.   Frontiers in Immunology

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Metabolic regulation of NLRP3

(2017) Mark M. Hughes et al.   IMMUNOLOGICAL REVIEWS

The impact of cellular metabolism on chromatin dynamics and epigenetics

(2017) Michael A. Reid et al.   NATURE CELL BIOLOGY

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Metabolism Supports Macrophage Activation

(2017) P. Kent Langston et al.   Frontiers in Immunology

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

(2016) Rob J.W. Arts et al.   Cell Metabolism

Metabolic control of methylation and acetylation

(2016) Xiaoyang Su et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair

(2016) Tamas Varga et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanisms of innate memory and tolerance to LPS

(2016) John J. Seeley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

(2016) Johan Garaude et al.   NATURE IMMUNOLOGY

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production

(2016) Walter A. Baseler et al.   Redox Biology

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

ATP-citrate lyase is essential for macrophage inflammatory response

(2013) Vittoria Infantino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic regulation of macrophage polarization and function

(2012) Lionel B. Ivashkiv   TRENDS IN IMMUNOLOGY

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Inflammatory signaling in macrophages: Transitions from acute to tolerant and alternative activation states

(2011) Lionel B. Ivashkiv   EUROPEAN JOURNAL OF IMMUNOLOGY

A Mouse Macrophage Lipidome

(2010) Edward A. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY